Role of macrophage colony-stimulating factor in the development of neointimal thickening following arterial injury

Mishra, Vivek; Sinha, Sharmistha; Rajavashisth, Tripathi B.

doi:10.1016/j.carpath.2016.04.003

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…In addition, studies suggest a number of mechanisms of atherosclerosis, including the thrombosis theory, lipid infiltration theory, damage reaction hypothesis, oxidative stress hypothesis, immune dysfunction hypothesis, homocysteine hypothesis and inflammatory reaction theory [8,9]. The vascular injury method combined with the use of a high-fat diet (HFD) may accelerate atherosclerosis progression [10,11].…”

Section: Introductionmentioning

confidence: 99%

Aggravated endothelial endocrine dysfunction and intimal thickening of renal artery in high-fat diet-induced obese pigs following renal denervation

Zhao

Yang

et al. 2020

BMC Cardiovasc Disord

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Background: Renal denervation (RDN) targeting the sympathetic nerves in the renal arterial adventitia as a treatment of resistant hypertension can cause endothelial injury and vascular wall injury. This study aims to evaluate the risk of atherosclerosis induced by RDN in renal arteries. Methods: A total of 15 minipigs were randomly assigned to 3 groups: (1) control group, (2) sham group, and (3) RDN group (n = 5 per group). All pigs were fed a high-fat diet (HFD) for 6 months after appropriate treatment. The degree of intimal thickening of renal artery and the conversion of endothelin 1 (ET-1) receptors were evaluated by histological staining. Western blot was used to assess the expression of nitric oxide (NO) synthesis signaling pathway, ET-1 and its receptors, NADPH oxidase 2 (NOX2) and 4-hydroxynonenal (4-HNE) proteins, and the activation of NF-kappa B (NF-κB). Results: The histological staining results suggested that compared to the sham treatment, RDN led to significant intimal thickening and significantly promoted the production of endothelin B receptor (ET B R) in vascular smooth muscle cells (VSMCs). Western blotting analysis indicated that RDN significantly suppressed the expression of AMPK/ Akt/eNOS signaling pathway proteins, and decreased the production of NO, and increased the expression of endothelin system proteins including endothelin-1 (ET-1), endothelin converting enzyme 1 (ECE1), endothelin A receptor (ET A R) and ET B R; and upregulated the expression of NOX2 and 4-HNE proteins and enhanced the activation of NF-kappa B (NF-κB) when compared with the sham treatment (all p < 0.05). There were no significant differences between the control and sham groups (all p > 0.05). Conclusions: RDN aggravated endothelial endocrine dysfunction and intimal thickening, and increased the risk of atherosclerosis in renal arteries of HFD-fed pigs.

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Section: Introductionmentioning

confidence: 99%

Aggravated endothelial endocrine dysfunction and intimal thickening of renal artery in high-fat diet-induced obese pigs following renal denervation

Zhao

Yang

et al. 2020

BMC Cardiovasc Disord

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“…For instance, surgical manipulation and associated disturbed flow may regulate expression of certain cytokines that stimulate macropinocytosis in the LCA model differently than in chronic hypercholesterolemia-induced atherosclerosis in the thoracic aorta. It is, however, important to add that physiologically relevant stimulators of macropinocytosis (thrombospondin-1, MCSF, and PDGF) have been shown to be up-regulated in the arterial wall in response to injury, disturbed flow, and chronic hyperlipidemiainduced inflammation (48)(49)(50).…”

Section: Discussionmentioning

confidence: 99%

Receptor-independent fluid-phase macropinocytosis promotes arterial foam cell formation and atherosclerosis

et al. 2022

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Accumulation of lipid-laden foam cells in the arterial wall plays a central role in atherosclerotic lesion development, plaque progression, and late-stage complications of atherosclerosis. However, there are still fundamental gaps in our knowledge of the underlying mechanisms leading to foam cell formation in atherosclerotic arteries. Here, we investigated the role of receptor-independent macropinocytosis in arterial lipid accumulation and pathogenesis of atherosclerosis. Genetic inhibition of fluid-phase macropinocytosis in myeloid cells ( LysMCre + Nhe1 fl/fl ) and repurposing of a Food and Drug Administration (FDA)–approved drug that inhibits macrophage macropinocytosis substantially decreased atherosclerotic lesion development in low-density lipoprotein (LDL) receptor–deficient and Apoe −/− mice. Stimulation of macropinocytosis using genetic ( H-RAS G12V ) and physiologically relevant approaches promoted internalization of unmodified native (nLDL) and modified [e.g., acetylated (ac) and oxidized (ox) LDL] lipoproteins in both wild-type and scavenger receptor (SR) knockout ( Cd36 −/− / Sra −/− ) macrophages. Pharmacological inhibition of macropinocytosis in hypercholesterolemic wild-type and Cd36 −/− / Sra −/− mice identified an important role of macropinocytosis in LDL uptake by lesional macrophages and development of atherosclerosis. Furthermore, serial section high-resolution imaging, LDL immunolabeling, and three-dimensional (3D) reconstruction of subendothelial foam cells provide visual evidence of lipid macropinocytosis in both human and murine atherosclerotic arteries. Our findings complement the SR paradigm of atherosclerosis and identify a therapeutic strategy to counter the development of atherosclerosis and cardiovascular disease.

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F2-isoprostanes affect macrophage migration and CSF-1 signalling

Proudfoot

Murrey

Mclean

et al. 2018

Free Radical Biology and Medicine

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Role of macrophage colony-stimulating factor in the development of neointimal thickening following arterial injury

Cited by 4 publications

References 46 publications

Aggravated endothelial endocrine dysfunction and intimal thickening of renal artery in high-fat diet-induced obese pigs following renal denervation

Aggravated endothelial endocrine dysfunction and intimal thickening of renal artery in high-fat diet-induced obese pigs following renal denervation

Receptor-independent fluid-phase macropinocytosis promotes arterial foam cell formation and atherosclerosis

F2-isoprostanes affect macrophage migration and CSF-1 signalling

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