Role of Macrophages and RhoA Pathway in Atherosclerosis

Kloc, Małgorzata; Uosef, Ahmed; Kubiak, Jacek Z.; Ghobrial, Rafik M.

doi:10.3390/ijms22010216

Cited by 22 publications

(20 citation statements)

References 76 publications

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“…Rho GEFs localize to the cell membrane where they cause activation of the Rho-GTP ( 35 ). Pro-inflammatory and anti-inflammatory macrophages are critical factors for the expansion, progression, or steadying of atherosclerotic plaque ( 5 ). Rho-GTP proteins, especially RhoA, control this process.…”

Section: The Emerging Role and Interaction Mechanisms Of Rho Gef In Atherosclerosismentioning

confidence: 99%

“…Small GTPases activated by Rho guanine nucleotide exchange factors (GEFs) partly or completely regulate endothelial cell migration and proliferation and adherens junctions of impermeable surfaces. In addition to the endothelium, inflammatory, or anti-inflammatory macrophages controlled by Rho GEFs, the small GTPase RhoA and its downstream effector, and Rho-associated coiled-coil containing kinases (ROCK) are also critical components for the development, regression, or stabilization of the atherosclerotic plaque ( 5 ). The mechanism of atherosclerosis is not fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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The Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review

Jiao²,

Xin

et al. 2022

Front. Cardiovasc. Med.

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Atherosclerosis is a leading cause of cardiovascular disease, and atherosclerotic cardiovascular disease accounts for one-third of global deaths. However, the mechanism of atherosclerosis is not fully understood. It is well-known that the Rho GTPase family, especially Rho A, plays a vital role in the development and progression of arteriosclerosis. Rho guanine nucleotide exchange factors (Rho GEFs), which act upstream of Rho GTPases, are also involved in the atheromatous pathological process. Despite some research on the role of Rho GEFS in the regulation of atherosclerosis, the number of studies is small relative to studies on the essential function of Rho GEFs. Some studies have preliminarily revealed Rho GEF regulation of atherosclerosis by experiments in vivo and in vitro. Herein, we review the advances in research on the relationship and interaction between Rho GEFs and atheroma to provide a potential reference for further study of atherosclerosis.

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Section: The Emerging Role and Interaction Mechanisms Of Rho Gef In Atherosclerosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review

Jiao²,

Xin

et al. 2022

Front. Cardiovasc. Med.

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“…Thus, in the CNTN4-RHOA transcript, the first untranslated exon of CNTN4, which is highly expressed in testis, replaced the first untranslated exon of RHOA, bringing the entire coding part of RHOA under control of the CNTN4 promoter (53). RHOA codes for a member of the Rho family of small GTPases with multiple cellular and biological functions (54)(55)(56)(57)(58). Dysregulation of RHOA and other members of the Rho family of small GTPases has been reported in many neoplasias (59,60).…”

Section: Discussionmentioning

confidence: 99%

Several Fusion Genes Identified in a Spermatic Cord Leiomyoma With Rearrangements of Chromosome Arms 3p and 21q

Panagopoulos

Gorunova

Andersen

et al. 2021

Cancer Genomics Proteomics

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Background/Aim: Benign smooth-muscle tumors, leiomyomas, occur in nearly every organ but are most common in the uterus. Whereas much is known about the genetics of uterine leiomyomas, little genetic information exists about leiomyomas of other organs. Here, we report and discuss the genetic findings in a para-testicular leiomyoma. Materials and Methods: Cytogenetic, array comparative genomic hybridization (aCGH) RNA sequencing, reverse-transcription polymerase chain reaction (RT-PCR), and Sanger sequencing analyses were performed on a leiomyoma of the spermatic cord removed from a 61year-old man. Results: The karyotype was 48~50,XY,add(3) (p21),+4,+7,+8,+9,add(21)(q22)[cp9]/46,XY[2]. aCGH confirmed the trisomies and also detected multiple gains and losses from 3p and 21q. RNA sequencing detected the chimeras ARHGEF3-CACNA2D2, TRAK1-TIMP4, ITPR1-DT-NR2C2, CLASP2-IL17RD, ZNF621-LARS2, CNTN4-RHOA, and NR2C2-CFAP410. All chimeras were confirmed by RT-PCR and Sanger sequencing. Conclusion: Our data, together with those previously published, indicate that a group of leiomyomas may be cytogenetically characterized by aberrations of 3p and the formation of fusion genes.

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“…These LDL modifications are prone to induce immune response; thus, the body forms highly atherogenic circulating LDL, which are involved in immune complexes ( Zhang et al, 2018a ). Other cell types are also involved in AS pathogenesis, such as macrophages and stem cells ( Wang et al, 2015a ; Takamura et al, 2017 ; Ruytinx et al, 2018 ; Kloc et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

New Insight in HDACs: Potential Therapeutic Targets for the Treatment of Atherosclerosis

et al. 2022

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Atherosclerosis (AS) features include progressive hardening and reduced elasticity of arteries. AS is the leading cause of morbidity and mortality. An increasing amount of evidence showed that epigenetic modifications on genes serve are a main cause of several diseases, including AS. Histone deacetylases (HDACs) promote the deacetylation at lysine residues, thereby condensing the chromatin structures and further inhibiting the transcription of downstream genes. HDACs widely affect various physiological and pathological processes through transcriptional regulation or deacetylation of other non-histone proteins. In recent years, the role of HDACs in vascular systems has been revealed, and their effects on atherosclerosis have been widely reported. In this review, we discuss the members of HDACs in vascular systems, determine the diverse roles of HDACs in AS, and reveal the effects of HDAC inhibitors on AS progression. We provide new insights into the potential of HDAC inhibitors as drugs for AS treatment.

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Role of Macrophages and RhoA Pathway in Atherosclerosis

Cited by 22 publications

References 76 publications

The Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review

The Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review

Several Fusion Genes Identified in a Spermatic Cord Leiomyoma With Rearrangements of Chromosome Arms 3p and 21q

New Insight in HDACs: Potential Therapeutic Targets for the Treatment of Atherosclerosis

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