2023
DOI: 10.7759/cureus.43076
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Role of Magnesium in Diabetic Nephropathy for Better Outcomes

Mahesh Mamilla,
Sai Goutham Reddy Yartha,
Richa Tuli
et al.

Abstract: Diabetic nephropathy (DN) is a major cause of end-stage renal disease worldwide, resulting from uncontrolled diabetes. Oxidative stress plays a critical role in the pathophysiology of DN, leading to cellular damage and disease progression. Magnesium, an essential mineral, has emerged as a potential therapeutic agent due to its antioxidative, anti-inflammatory, and antifibrotic properties. An extensive literature search was conducted on Medline using the keywords “Diabetic nephropathy,” “Magnesium,” and “Chroni… Show more

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“…At the other end of the spectrum, a narrow frame of intervention should be taken into consideration since hypermagnesaemia is also detrimental in chronic kidney disease as it may contribute to adynamic bone disease and osteomalacic renal osteodystrophy [ 113 ]. The pathway that leads from an adequate dietary magnesium intake to a better outcome of diabetic nephropathy, though incompletely understood, also includes the antioxidant properties of magnesium and its involvement in reducing inflammation and oxidative stress, as well as the role in blood pressure control [ 114 ].…”
Section: Discussionmentioning
confidence: 99%
“…At the other end of the spectrum, a narrow frame of intervention should be taken into consideration since hypermagnesaemia is also detrimental in chronic kidney disease as it may contribute to adynamic bone disease and osteomalacic renal osteodystrophy [ 113 ]. The pathway that leads from an adequate dietary magnesium intake to a better outcome of diabetic nephropathy, though incompletely understood, also includes the antioxidant properties of magnesium and its involvement in reducing inflammation and oxidative stress, as well as the role in blood pressure control [ 114 ].…”
Section: Discussionmentioning
confidence: 99%