Role of Major Histocompatibility Complex and Ethnicity in Acute Renal Graft Rejection

Torres-Machorro, Adriana; Camorlinga-Tagle, N.; Rodriguez‐Ortiz, Carlos J.; Palafox, Damián; González, Norma; López, Mayra; Castelán, Natalia; Leo, Claudia de; Vilatobá, Mario; Gabilondo, Bernardo; Gómez, Josefina Alberú; Morales-Buenrostro, L. E.; Granados, Julio

doi:10.1016/j.transproceed.2010.05.006

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…In transplant medicine, several works have studied the effects of genetic variants of a wide range of proteins including Human Leukocyte Antigens (HLA) in the risk of rejection in allograft transplants [ 15 – 17 , 53 , 54 ]. For example, in Mexico, some works have found a positive association between specific HLA haplotypes and acute kidney rejection [ 15 , 17 ]. Interestingly, those immunogenic variants are widely distributed among indigenous and mestizo people [ 47 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Blood Groups Distribution and Gene Diversity of the ABO and Rh (D)Lociin the Mexican Population

Canizalez-Román

Campos‐Romero²,

Castro-Sánchez³

et al. 2018

BioMed Research International

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Objective To determine the frequency and distribution of ABO and Rh (D) antigens and, additionally, investigate gene diversity and the structure of Mexican populations. Materials and Methods Blood groups were tested in 271,164 subjects from 2014 to 2016. The ABO blood group was determined by agglutination using the antibodies anti-A, Anti-B, and Anti-D for the Rh factor, respectively. Results The overall distribution of ABO and Rh (D) groups in the population studied was as follows: O: 61.82%; A: 27.44%; B: 8.93%; and AB: 1.81%. For the Rh group, 95.58% of people were Rh (D), and 4.42% were Rh (d). Different distributions of blood groups across regions were found; additionally, genetic analysis revealed that the IO and ID allele showed an increasing trend from the north to the center, while the IA and Id allele tended to increase from the center to the north. Also, we found more gene diversity in both loci in the north compared with the center, suggesting population structure in Mexico. Conclusion This work could help health institutions to identify where they can obtain blood products necessary for medical interventions. Moreover, this piece of information contributes to the knowledge of the genetic structure of the Mexican populations which could have significant implications in different fields of biomedicine.

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