Role of Male Infertility in Assisted Reproductive Technology Programs (A Literature Review)

Background. Robertsonian translocations (RTs) are the most common type of balanced chromosomal abnormalities. RT male carriers have an increased risk of reproductive disorders, but the causes of this still are not clear enough.Aim. To evaluate semen parameters in RT(13;14) male carriers.Materials and methods. 24 men with 45,XY,der(13;14)(q10;q10) karyotype and infertility (n = 23) or recurrent pregnancy loss in spouse (n = 1).Results. Oligoasthenoteratozoospermia was detected in 18 (75 %) patients, asthenoteratozoospermia in 3 (13 %) patients, and azoospermia in 2 (8 %) patients. Normozoospermia was detected in 1 (4 %) patient, whose wife had a history of recurrent pregnancy loss.Conclusion. Infertility in the examined RT male carriers is associated with spermatogenesis disorders, in most cases resulted in oligozooasthenoteratozoospermia.

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Semen parameters in male carriers of Robertsonian translocations (13;14)

Андреева

Курило

Shtaut

et al. 2023

Androl. genit. hir.

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The Sixth Edition of the WHO laboratory manual for the examination and processing of human semen: is everything new a well-forgotten old?

Olefir

Виноградов

Rodionov³

et al. 2023

Vestn. Urol.

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Despite many shortcomings, the semen analysis remains the leading method of male fertility assessment. For several decades, the WHO has been working on standardisation of the methodology for examining human ejaculate. In 2021, the sixth edition of WHO laboratory manual for the examination and processing of human semen was released, which proposed several concepts for performing and interpreting the results of a semen analysis. Many of these concepts are not new and have already been covered in previous tutorials. At the same time, the rejection of reference values and the transition to “decision limits” raises several questions that have not yet been answered.

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Role of Male Infertility in Assisted Reproductive Technology Programs (A Literature Review)

Cited by 2 publications

References 50 publications

Semen parameters in male carriers of Robertsonian translocations (13;14)

Semen parameters in male carriers of Robertsonian translocations (13;14)

The Sixth Edition of the WHO laboratory manual for the examination and processing of human semen: is everything new a well-forgotten old?

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