Role of MAP kinase on MMP-13 expression in rat periodontal ligament cells

The effect of Actinobacillus actinomycetemcomitans lipopolysaccharide on rat periodontal tissues

“…As regards to periodontal tissue destruction, proinflammatory cytokines stimulate metalloproteinases such as MMP-1, MMP-3, and MMP-13, which degrade extracellular matrix components in periodontium 31,32) . Moreover, IL-1 and TNF-α induce bone resorption by indirectly stimulating IL-6 or directly stimulating downstream effectors associated with osteoclast differentiation and activation, such as receptor activator of nuclear factor kappa B ligand (RANKL).…”

“…Recent studies of both osteoblasts and periodontal ligament fibroblasts have shown that the IL-1β or TNF-α-induced MMP-13 production can be blocked with p38 MAP kinase inhibitors 32,33) . It was confirmed that A. actinomycetemcomitans LPS-induced MMP-13 expression was repressed by p38 MAP kinase inhibitors in our lab.…”