Role of Marginal Vitamin C Deficiency in Atherogenesis: <i> In Vivo</i> Models and Clinical Studies

Frikke-Schmidt, Henriette; Lykkesfeldt, Jens

doi:10.1111/j.1742-7843.2009.00420.x

Cited by 52 publications

(35 citation statements)

References 179 publications

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“…This model in contrast to others, enabled the effect of AA deficiency on lipid metabolism and atherosclerosis to be followed in long term experiments. In protracted hypovitaminosis C lasting for 10 weeks, there was a considerable accumulation of cholesterol in liver and also increased concentration in serum [83][84][85].…”

Section: Vitamin C and Atherosclerosismentioning

confidence: 99%

Vitamin C in Disease Prevention and Cure: An Overview

et al. 2013

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The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections. However the significance and beneficial effect of vitamin C in respect to human disease such as cancer, atherosclerosis, diabetes, neurodegenerative disease and metal toxicity however remains equivocal. Thus further continuous uninterrupted efforts may open new vistas to understand its significance in disease management.

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Section: Vitamin C and Atherosclerosismentioning

confidence: 99%

Vitamin C in Disease Prevention and Cure: An Overview

et al. 2013

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“…A dysfunctional endothelium is observed in many diseases and conditions such as diabetes, coronary artery disease, atherosclerosis and hypertension [1]. Endothelial dysfunction (ED) is in part due to an imbalance between vasoconstricting and vasodilating substances produced by or acting on the endothelium.…”

Section: Introductionmentioning

confidence: 99%

Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo

et al. 2013

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“…Vitamin C is a pivotal redox modulator in many biological reactions. Growing epidemiological, clinical and experimental evidence now suggests a more specifi c role of ascorbate in vasomotion and in the prevention of atherosclerosis (30). For endothelial cells, ascorbate helps to prevent endothelial dysfunction, stimulates type IV collagen synthesis, and enhances cell proliferation.…”

Section: Antioxidantsmentioning

confidence: 99%

Update on medical management of dyslipidemia and atherosclerosis

Ginter

Simko²

2013

BLL

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Scientifi c achievements revealing the pathogenesis of atherosclerosis resulted in the second half of the 20th century in major improvement in prevention and therapy of cardiovascular disorders (CVD). Essential became the understanding of a critical pathogenetic role of the low-density lipoproteins (LDL), mainly their oxidized form (oxLDL) and also the protective potential of the high-density lipoproteins (HDL). CVD is now regarded to be an infl ammatory disease in which a systemic infl ammatory reaction is combined with an accumulation of immune cells in atherosclerotic plaques. Higher intake of antioxidants in fruit and vegetable, life style modifications, cessation of smoking, physical exercise and introduction of medications that lower LDL and promote HDL (statins, niacin and fi brates) resulted in a substantial decline of the killer effect of unmanaged CVD. In the United Kingdom the male CVD mortality declined between 1970 and 2009 from 700 to 200 deaths per 100,000. In France, CVD mortality in the middle age population (25-64 years) is now responsible for death in only 15 % men and in 11 % women. Unfortunately, in many parts of the world CVD mortality remains a prominent population scourge. Recent dicoveries, especially on the role of peroxisome proliferator-activated receptors (PPAR) and antisense compounds used in addition to established anti-atherogenic medications, promise further gains in the fi ght against atherosclerosis (Fig. 4, Ref. 54). Full Text in PDF www.elis.sk.

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Role of Marginal Vitamin C Deficiency in Atherogenesis: In Vivo Models and Clinical Studies

Abstract: Vitamin C is a pivotal redox modulater in many biological reactions of which several remain poorly understood.

Cited by 52 publications

References 179 publications

Vitamin C in Disease Prevention and Cure: An Overview

Vitamin C in Disease Prevention and Cure: An Overview

Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo

Update on medical management of dyslipidemia and atherosclerosis

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