Role of MARK2 in the nervous system and cancer

Lei, Yining; Zhang, Ruyi; Cai, Fei

doi:10.1038/s41417-024-00737-z

Cited by 3 publications

(1 citation statement)

References 131 publications

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“…The nervous system is involved in the occurrence, development, and regulation of many diseases ( 108 , 109 , 61 ). The interaction between the microbiome and the central nervous system occurs primarily through the vagus nerve, with afferent fibers transmitting information influenced by microbiome metabolites back to the central nervous system ( 110 ).…”

Section: Discussionmentioning

confidence: 99%

Current landscape of fecal microbiota transplantation in treating depression

Zhang,

Bi,

Zhang

et al. 2024

Front. Immunol.

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Depression, projected to be the predominant contributor to the global disease burden, is a complex condition with diverse symptoms including mood disturbances and cognitive impairments. Traditional treatments such as medication and psychotherapy often fall short, prompting the pursuit of alternative interventions. Recent research has highlighted the significant role of gut microbiota in mental health, influencing emotional and neural regulation. Fecal microbiota transplantation (FMT), the infusion of fecal matter from a healthy donor into the gut of a patient, emerges as a promising strategy to ameliorate depressive symptoms by restoring gut microbial balance. The microbial-gut-brain (MGB) axis represents a critical pathway through which to potentially rectify dysbiosis and modulate neuropsychiatric outcomes. Preclinical studies reveal that FMT can enhance neurochemicals and reduce inflammatory markers, thereby alleviating depressive behaviors. Moreover, FMT has shown promise in clinical settings, improving gastrointestinal symptoms and overall quality of life in patients with depression. The review highlights the role of the gut-brain axis in depression and the need for further research to validate the long-term safety and efficacy of FMT, identify specific therapeutic microbial strains, and develop targeted microbial modulation strategies. Advancing our understanding of FMT could revolutionize depression treatment, shifting the paradigm toward microbiome-targeting therapies.

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Section: Discussionmentioning

confidence: 99%

Current landscape of fecal microbiota transplantation in treating depression

Zhang,

Bi,

Zhang

et al. 2024

Front. Immunol.

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SARS‐CoV‐2‐derived protein Orf9b enhances MARK2 activity via interaction with the autoinhibitory KA1 domain

Homma,

Limlingan,

Saito

et al. 2024

FEBS Letters

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Microtubule affinity‐regulating kinase 2 (MARK2) is a Ser/Thr protein kinase that regulates cell polarity and immune responses. Here, we report that Orf9b, one of the accessory proteins encoded in the SARS‐CoV‐2 genome, increases MARK2 activity via interaction with the autoinhibitory KAI domain. We found that co‐expression of Orf9b enhances the kinase activity of MARK2 in HEK293 cells. Orf9b does not bind to or enhance the activity of the mutant form of MARK2 lacking the KA1 domain. Orf9b lowers inhibitory phosphorylation of MARK2 at T595 while mutation experiments indicate that this site is dispensable for Orf9b‐mediated enhancement of MARK2 activity. Our results suggest that Orf9b enhances MARK2 activity by binding the autoinhibitory KA1 domain, which closely interacts with the kinase domain.

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Innovative Drug Discovery: Targeting Cancer, Neurological Disorders, and Obesity

Kargbo

2024

ACS Med. Chem. Lett.

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The landscape of therapeutic innovation is rapidly evolving, with significant advances in cancer treatment, obesity management, and the modulation of protein interactions in neurodegenerative disorders. This Patent Highlight explores the scientific breakthroughs described in four recent patents covering novel therapeutic compounds, advanced methods for identifying E3 ligase substrates, and developing new strategies for combating obesity and its related metabolic disorders. These innovations, focusing on specific molecular targets and pathways, promise more effective and personalized treatment options, addressing unmet needs in oncology, neurology, and metabolic health.

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Role of MARK2 in the nervous system and cancer

Cited by 3 publications

References 131 publications

Current landscape of fecal microbiota transplantation in treating depression

Current landscape of fecal microbiota transplantation in treating depression

SARS‐CoV‐2‐derived protein Orf9b enhances MARK2 activity via interaction with the autoinhibitory KA1 domain

Innovative Drug Discovery: Targeting Cancer, Neurological Disorders, and Obesity

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