Role of mast cells in pathogenesis of oral lichen planus

Sharma, Rahul Swarup; Sircar, Keya; Singh, Sanjeet; Rastogi, Vishal

doi:10.4103/0973-029x.86674

Cited by 31 publications

(29 citation statements)

References 7 publications

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“…It is known that innate immune recognition of cells undergoing apoptosis, as a direct result of infection, is a physiological stimulus for Th17 cell differentiation. 56 Mast cells, also thought to play a role in pathogenesis, 15,27,50,62 are found in higher numbers in the deeper stromal tissue (as found in our dog study population) and often co-localize with IL-17þ cells.…”

Section: Discussionmentioning

confidence: 89%

“…Mast cells were generally located in areas away from (deep to) the intense lichenoid/ interface inflammation, and their role in CCUS lesion pathogenesis is therefore unclear. 15,27,50 Eosinophils were essentially absent from the examined tissue sections; therefore, an allergic response appears to be unlikely. The finding of IL-17-producing non-T cells in tissue sections is consistent with prior reports of chronic idiopathic inflammatory lesions in dogs, where most of the IL-17þ cells were CD3 negative.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis

et al. 2017

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Canine chronic ulcerative stomatitis, also known as chronic ulcerative paradental stomatitis, is a painful condition of the oral cavity. The purpose of this study was to determine if there are commonalities in clinical and radiographic features among patients, whether the histopathologic evaluation might inform the pathogenesis, and whether the condition appears similar to human oral mucosal diseases. To do this, we prospectively collected clinical, radiographic, and histopathologic data from 20 dogs diagnosed with the disease. Clinical data were based on a clinical disease activity index, oral and periodontal examination parameters, and full-mouth dental radiographs. The histopathological and immunohistochemical data were based on oral mucosal samples obtained from erosive or ulcerated areas. Our findings revealed that canine chronic stomatitis is clinically characterized by painful oral mucosal ulcers of varying size, pattern, appearance, and distribution, most often associated with teeth with early periodontitis. Histologic examination revealed a subepithelial lichenoid band (interface mucositis) where B cells, T cells, and Forkheadbox protein 3 (FoxP3)-and interleukin-17-expressing cells were present. These cells might play a role in the underlying immune response and an immune-mediated pathogenesis is suspected. The clinical and histopathologic features of this chronic inflammatory mucosal disease in dogs resemble those of oral lichen planus in humans.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis

et al. 2017

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“…Mast cells also have a role in immune-related diseases such as rheumatoid arthritis, asthma, psorisaisis, etc. 52,53 …”

Section: Discussionmentioning

confidence: 99%

Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus

Adami

Yeung

Stucki

et al. 2014

Archives of Oral Biology

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Objective Oral lichen planus (OLP) is a disease of the oral mucosa of unknown cause producing lesions with an intense band-like inflammatory infiltrate of T cells to the subepithelium and keratinocyte cell death. We performed gene expression analysis of the oral epithelium of lesions in subjects with OLP and its sister disease, oral lichenoid reaction (OLR), in order to better understand the role of the keratinocytes in these diseases. Design Fourteen patients with OLP or OLR were included in the study, along with a control group of 23 subjects with a variety of oral diseases and a normal group of 17 subjects with no clinically visible mucosal abnormalities. Various proteins have been associated with OLP, based on detection of secreted proteins or changes in RNA levels in tissue samples consisting of epithelium, stroma, and immune cells. The mRNA level of twelve of these genes expressed in the epithelium was tested in the three groups. Results Four genes showed increased expression in the epithelium of OLP patients: CD14, CXCL1, IL8, and TLR1, and at least two of these proteins, TLR1 and CXCL1, were expressed at substantial levels in oral keratinocytes. Conclusions Because of the large accumulation of T cells in lesions of OLP it has long been thought to be an adaptive immunity malfunction. We provide evidence that there is increased expression of innate immune genes in the epithelium with this illness, suggesting a role for this process in the disease and a possible target for treatment.

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“…Similar results were observed in study conducted by Byahatti et al 9 Mast cells migrate from blood vessels in the deeper connective tissue to the extravascular compartment and subsequently toward the subepithelial zone, where they exert their biologic effect on blood vessels and help in recruitment of inflammatory cells to the lesional area. 20 This reason possibly justifies presence of burning sensation in patients suffering from lichen planus. Majority of the lesions were found on dorsum of tongue (77.9%), which was statistically significant.…”

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confidence: 99%