Role of Maternal Immunoglobulins Blocking TSH-Induced Thyroid Growth in Sporadic Forms of Congenital Hypothyroidism

Gaag, R. D. van der; Drexhage, Hemmo A.; Dussault, J H

doi:10.1016/s0140-6736(85)91028-1

Cited by 105 publications

(23 citation statements)

References 19 publications

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“…On the other hand, as in our study, Glinoer et al [26] in their study on pregnancy in patients with mild thyroid abnormality, such as goiter, nodules and thyroid autoantibodies, reported that thyroid function in newborns from mothers with thyroid abnormalities was normal and not different from that in controls. However, considering that goiter and other non-developmental abnormalities are related to environmental and autoimmune factors and also the role of these factors on CH [7,8,9], it is recommended that more studies in this field are needed in order to study the rate of autoimmunity and thyroid disorders in relation with the CH etiologies mentioned earlier.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of TD is not known. The possible role of autoimmune or unidentified environmental factors has been suggested, but not confirmed [7,8,9]. In the remaining 15%, CH is associated with congenital goiter and results in dyshormonogenesis, with a defect in one of the biochemical mechanisms being responsible for thyroid hormone synthesis [10].…”

Section: Introductionmentioning

confidence: 99%

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Thyroid Abnormalities among First-Degree Relatives of Children with Congenital Hypothyroidism: An Ultrasound Survey

Adibi¹,

Haghighi²,

Hosseini³

et al. 2008

Horm Res Paediatr

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Background: Congenital hypothyroidism (CH) is caused by thyroid dysgenesis and dyshormonogenesis. Evidence suggests the presence of genetic factors in both types of pathogenesis. We investigated whether an increased incidence of thyroid abnormalities could be shown by ultrasonography among first-degree relatives of children with CH. Material and Methods: In this case-control study the presence of both developmental and non-developmental thyroid abnormalities was studied among first-degree relatives of CH patients and healthy children. Assessments included neck ultrasonography and thyroid function tests. The data obtained from parents, siblings and children were compared in the case and control groups. Results: In the case group, 92 patients, 172 parents and 57 siblings, and in the control group, 82 healthy children, 160 parents and 39 siblings were studied. Thyroid developmental abnormalities were more prevalent among parents (3.5 vs. 0%, p = 0.03) and siblings (10.5 vs. 0, p = 0.01) of CH patients than the control group. Non-developmental abnormalities were not significantly different between the case and control groups (17 vs. 13%, p = 0.3). Conclusion: Thyroid developmental abnormalities were more prevalent among parents and siblings of CH patients than the control group, confirming the familial component of this entity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thyroid Abnormalities among First-Degree Relatives of Children with Congenital Hypothyroidism: An Ultrasound Survey

Adibi¹,

Haghighi²,

Hosseini³

et al. 2008

Horm Res Paediatr

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“…During the fetal period, maternal antibodies against thyroid antigens are responsible for the etiology of the arrested descent of the thyroid anlage from its original location at the dorsum of the tongue down to its normal location (5). An ectopic thyroid is a rarely detected anomaly, occurring in approximately 1 in 3000 to 1 in 10 000 people (6).…”

Section: Lingual Thyroidmentioning

confidence: 99%

CT and MRI findings of developmental abnormalities and ectopia varieties of thyroid gland

Altay¹,

Erdoğan²,

Karasu³

et al. 2011

Diagn Interv Radiol

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“…The passive transfer of maternal TSH-blocking antibodies is a cause of neonatal hypothyroidism, but the disease is transient following the disappearance of the antibodies [6]. Therefore, there are few reports indicating that such blocking antibodies result in permanent hypothyroidism [7,8]. To understand the role of an immunological mechanism in the etiology of thyroid atrophy in endemic cretinism, we investigated the effects of circulating serum IgG fractions from nongoitrous cretins in an area of iodine deficiency, Xinjiang, northwest China, on thyroid growth .…”

Section: Cretinismmentioning

confidence: 99%

Blocking Type Immunoglobulins in Patients with Nongoitrous Primary Hypothyroidism in Area of Iodine Deficinecy.

et al. 1991

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Abstract. We have evaluated the role of circulating serum immunoglobulins (IgG) which inhibit the growth of thyroid in the etiology of thyroid atrophy in endemic cretinism. Twenty nongoitrous cretins (13 women and 7 men, age range: 9-33) were classified on the basis of clinical criteria for cretinism in China. They were born and living in an iodine deficient area, Xinjiang, northwest China. Antimicrosomal antibody titers were negative in all serum. Nine patients (seven women and two men; age range: 11-23) were biologically primary hypothyroid. Seven subjects were of a myxedematous form and two subjects were of a mixed form. We have studied thyroid-growth inhibiting immunoglobulin (TGII) activity that was measured as an inhibitory effect of 4mg/ml IgG on TSH-induced [3H]-thymidine incorporation into the DNA of a rat thyroid follicular cell line, FRTL5 cells. Six (five women and one man) out of the nine patients with primary hypothyroidism (66.7 percent) had TGII. We also measured other growth-blocking IgG that inhibited [3H]-thymidine incorporation into DNA stimulated by insulin-like growth factor-I (IGF-I), a growth factor working through a cAMP-independent pathway. Five (three women and two men) out of nine patients (55.6 percent) with nongoitrous primary hypothyroidism had IGF-I-blocking IgG. These results indicate that TGII plays an important role in atrophy of the thyroid in spite of increased serum TSH concentrations, and IgG which inhibits thyroid growth stimulated by IGF-I also might play a role in thyroid atrophy in some endemic cretins. An autoimmune process might be involved in the pathogenesis of hypothyroidism secondary to thyroid atrophy, though severe iodine deficiency is a cause of endemic cretinism.

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Role of Maternal Immunoglobulins Blocking TSH-Induced Thyroid Growth in Sporadic Forms of Congenital Hypothyroidism

Cited by 105 publications

References 19 publications

Thyroid Abnormalities among First-Degree Relatives of Children with Congenital Hypothyroidism: An Ultrasound Survey

Thyroid Abnormalities among First-Degree Relatives of Children with Congenital Hypothyroidism: An Ultrasound Survey

CT and MRI findings of developmental abnormalities and ectopia varieties of thyroid gland

Blocking Type Immunoglobulins in Patients with Nongoitrous Primary Hypothyroidism in Area of Iodine Deficinecy.

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