Role of maternal vitamins in programming health and chronic disease

Pannia, Emanuela; Cho, Clara E.; Kubant, Ruslan; Sánchez‐Hernández, Diana; Huot, Pedro S.P.; Anderson, G. Harvey

doi:10.1093/nutrit/nuv103

Cited by 34 publications

(17 citation statements)

References 111 publications

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“…We have found studies that report a positive association for vitamin B2 [ 53 ], B9 [ 23 , 26 , 28 ], and B12 [ 23 , 28 , 39 ], while others have found an absence of effect for vitamin B9 [ 24 , 27 , 52 , 54 ] and B12 [ 24 , 26 , 54 ]. Our data, in contrast, show a protective effect for B9 and B12, both of which have an important role in supporting maternal and fetal health during pregnancy to build and preserve maternal stores and meet the needs of rapidly growing tissues [ 55 ] and increase the risk of neural tube defects and may contribute to preterm birth [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Vitamin Intake during Pregnancy and Risk of Small for Gestational Age

et al. 2017

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Pregnancy increases the requirements of certain nutrients, such as vitamins, to provide nutrition for the newborn. The aim was to analyze the association between dietary intake of vitamins during pregnancy and risk of having a small for gestational age (SGA) newborn. A matched case-control study was conducted (518 cases and 518 controls of pregnant women) in Spain. Dietary vitamin intake during pregnancy was assessed using a validated food frequency questionnaire, categorized into quintiles. Odds ratios (ORs) and their 95% confidence intervals (CI) were estimated with conditional regression logistic models. A protective association was observed between maternal dietary intake of vitamins A and D and SGA. For vitamin B3 and B6, the observed protective effect was maintained after adjusting for potential confounding factors. For vitamin B9, we found only an effect in quintiles 3 and 4 (OR = 0.64; 95% CI, 0.41–1.00; OR = 0.58; 95% CI, 0.37–0.91). Protective effect for vitamin B12 was observed in 4th and 5th quintiles (OR = 0.61; 95% CI, 0.39–0.95; OR = 0.68; 95% CI, 0.43–1.04). No associations were detected between dietary intake of vitamins B2, E and C intake and SGA. Our results suggest a positive association between dietary vitamin intake during pregnancy and the weight of the newborn, although more studies are necessary and there could be a ceiling effect for higher intakes of some vitamins cannot be discarded.

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Section: Discussionmentioning

confidence: 99%

Association between Vitamin Intake during Pregnancy and Risk of Small for Gestational Age

et al. 2017

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“…This observation suggests that obese mothers might be at higher risk of SGA as well, but such an association is not observed consistently [13, 14]. There have been numerous reviews of the effects of dietary, exercise and lifestyle interventions on birthweight [13, 15–18], as well as associations between dietary intake and birthweight [13, 19–21]. However, these have not addressed why fetal growth is normal in many obese and diabetic pregnancies but altered in others [22].…”

Section: Introductionmentioning

confidence: 99%

Effects of high-fat diets on fetal growth in rodents: a systematic review

Christians

Lennie

Wild

et al. 2019

Reprod Biol Endocrinol

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Background Maternal nutrition during pregnancy has life-long consequences for offspring. However, the effects of maternal overnutrition and/ or obesity on fetal growth remain poorly understood, e.g., it is not clear why birthweight is increased in some obese pregnancies but not in others. Maternal obesity is frequently studied using rodents on high-fat diets, but effects on fetal growth are inconsistent. The purpose of this review is to identify factors that contribute to reduced or increased fetal growth in rodent models of maternal overnutrition. Methods We searched Web of Science and screened 2173 abstracts and 328 full texts for studies that fed mice or rats diets providing ~ 45% or ~ 60% calories from fat for 3 weeks or more prior to pregnancy. We identified 36 papers matching the search criteria that reported birthweight or fetal weight. Results Studies that fed 45% fat diets to mice or 60% fat diets to rats generally did not show effects on fetal growth. Feeding a 45% fat diet to rats generally reduced birth and fetal weight. Feeding mice a 60% fat diet for 4–9 weeks prior to pregnancy tended to increase in fetal growth, whereas feeding this diet for a longer period tended to reduce fetal growth. Conclusions The high-fat diets used most often with rodents do not closely match Western diets and frequently reduce fetal growth, which is not a typical feature of obese human pregnancies. Adoption of standard protocols that more accurately mimic effects on fetal growth observed in obese human pregnancies will improve translational impact in this field. Electronic supplementary material The online version of this article (10.1186/s12958-019-0482-y) contains supplementary material, which is available to authorized users.

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“…Multiple methyl donor nutrients and cofactors (highlighted in gray, Figure 1) are essential nutrients provided solely by the diet. Studies have shown that deficiency, imbalance or excess of one of more of these nutrients throughout various periods of life can alter development, cognition and disease risk (Pannia et al 2016; Veena et al 2016; Morris 2012; Reynolds 2006; O’Neill et al 2014). We previously reported that MDS given concurrently with a 60% HF diet during pregnancy and lactation normalizes palatable food preference, increases locomotor activity, and normalizes gene expression and both gene specific and global DNA hypomethylation in male and female offspring (Carlin et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain

McKee

Zhang

Chen

et al. 2018

Journal of Neurochemistry

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One carbon metabolism is regulated by the availability of nutrients known as methyl donors, and disruption of this pathway can affect multiple physiological systems. DNA methylation, critical for the regulation of gene expression, is linked to one carbon metabolism, and can be altered by perinatal diet. In this study, dams (n = 12/group) were fed HF or standard control (SC) diet through pregnancy and lactation, and male and female offspring were then fed either SC or methyl donor-supplemented diet (MDS) between 3 and 6 weeks of age (n = 20-26/group). Concentration of one carbon intermediates and other related metabolites were assessed within brain tissue (prefrontal cortex, PFC) through the use of mass spectrometry at 6 weeks of age. In addition, the expression of target genes and enzymes that participate in DNA methylation or are relevant to one carbon metabolism were measured. We found that MDS increases the concentration of folate intermediates in the PFC, and that this increase is blunted in male offspring from dams fed a HF diet. In addition, perinatal HF diet increased the concentration of cysteine in the PFC of both male and female offspring, consistent with oxidative stress. Furthermore, both maternal HF diet and postnatal MDS altered global DNA methylation in the PFC in males but not females. Collectively, these data demonstrate sex differences in changes in one carbon metabolites in the prefrontal cortex in response to early life high fat diet and methyl donor supplementation. Read the Editorial Highlight for this article on page 358.

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Role of maternal vitamins in programming health and chronic disease

Cited by 34 publications

References 111 publications

Association between Vitamin Intake during Pregnancy and Risk of Small for Gestational Age

Association between Vitamin Intake during Pregnancy and Risk of Small for Gestational Age

Effects of high-fat diets on fetal growth in rodents: a systematic review

Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain

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