Role of Melatonin in Preterm Birth

Khan, Zeeshan Ahmad; Mondal, Gopinath; Sharma, Chandresh; Falak, Shahkar; Ansari, AbuZar; Chattoraj, Asamanja

doi:10.33069/cim.2020.0024

Cited by 1 publication

(1 citation statement)

References 65 publications

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“…Data on the assessment of endogenous melatonin and its effectiveness in the prevention of BPD are limited, but some authors have investigated the efficacy of exogenous melatonin in RDS in premature infants. These studies have shown that melatonin reduced oxidative stress and serum pro-inflammatory interleukins in neonates with RDS, decreased pro-inflammatory cytokines in tracheobronchial aspirate, and improved outcomes due to its antioxidant effects, thus have been reducing the risk of BPD ( 16 , 19 , 20 ). In addition, Choi et al found that melatonin promoted the development of lung architecture and protected the lungs during critical alveolarization processes after preterm birth ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

The relationship of melatonin concentration in preterm infants and adverse outcomes in the late neonatal period

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Sarapuk

Kozak³

2022

Biochem. med. (Online)

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Introduction:The aim of research was to assess the melatonin concentrations in the early neonatal period as a predictor of adverse outcomes of late neonatal period in preterm infants and to estimate its optimal predictive cut-off values. Materials and methods: A total of 115 preterm infants admitted to the neonatal intensive care unit were screened for eligibility, five did not meet the criteria, six parents declined the participation. So, a total of 104 preterm infants with gestational age 25-34 weeks were included in research. The concentration of melatonin in urine was determined by the Enzyme Immunoassay method (Human Melatonin Sulfate ELISA kit, Elabscience, China). The Mann-Whitney U-test and analysis of the receiver operating characteristic (ROC) curve were used in statistical analysis. Results: Analysis of the ROC curves has revealed optimal cut-off values for urinary melatonin concentration to predict late outcomes. Melatonin concentration below 3.58 ng/ml with sensitivity of 72% can predict development of retinopathy of prematurity (ROP) (AUC = 0.73; 95% confidence intervals (CI) 0.61-0.86). Good diagnostic accuracy (AUC = 0.80; 95% CI 0.67-0.93) has been shown for bronchopulmonary dysplasia (BPD). The optimal cut-off value for melatonin concentration in BPD prediction is 3.71 ng/ml (sensitivity 80%, specificity 64%). Urinary melatonin concentration below 3.79 ng/ml can be associated with late-onset sepsis (AUC = 0.76; 95% CI 0.64-0.87; sensitivity 72%; specificity 62%). There were no significant associations between melatonin concentration and necrotizing enterocolitis (P = 0.912). Conclusion: Urinary melatonin concentration below the certain cut-off values in the early neonatal period may serve as one of the predictors of adverse outcomes such as BPD, ROP, and late-onset sepsis in the late neonatal period in preterm infants.

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