Role of Mentzer index for differentiating iron deficiency anemia and beta thalassemia trait in pregnant women

Tabassum, Shagufta; Khakwani, Mehnaz; Fayyaz, Asiya; Taj, Nadia

doi:10.12669/pjms.38.4.4635

Cited by 17 publications

(5 citation statements)

References 16 publications

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“…The study found that Mentzer index more than 13 (indicating IDA) and <13 (indicating thalassemia) was a reliable screening tool to differentiate between IDA and thalassemia. Similar findings were also reported by authors such as Tabassum et al [19] and Shah et al [20]…”

Section: Discussionsupporting

confidence: 92%

Haematological Profile and Mentzer Index in Pediatric Patients Presenting With Anemia

AGGARWAL,

MODI,

et al. 2024

Asian J Pharm Clin Res

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Objective: The objective of this study was to analyze clinical and hematological profile of children with anemia and determine the Mentzer index of all cases presenting with anemia. Methods: This was a cross-sectional observational study conducted in the Department of pediatrics of a tertiary care medical college. Eighty pediatric age group patients diagnosed to be having anemia on clinical examination were included in this study. Demographic details such as age and gender were noted in all cases. A through history was obtained and a clinical examination was done. Presenting complaints were also noted. Complete blood count with peripheral blood smear examination was done in all cases. The Mentzer index was determined from complete blood count reports. Results: Out of 80 studied cases, there were 57 (71.25%) boys and 23 (28.75%) girls. The mean age for boys was 9.12±3.14 years and for girls, it was slightly higher at 10.24±3.46 years. Fatigue (73.75%), pallor (71.25%), and anorexia (56.25%) were common complaints. About 55% had mild anemia 22.5% had moderate anemia and 22.5% suffered from severe. Mean hemoglobin concentration of studied cases was found to be 8.42±3.98 g/dL. The most prevalent blood picture was the normocytic normochromic blood picture, representing 60% of cases. Mentzer index ranged from a minimum of 10.83 to a maximum of 27.76, with the mean value being 17.40±2.92. Notably, the vast majority of patients (97.5%) had a Mentzer Index >13, suggesting a high prevalence of iron deficiency. Conversely, only 2.5% of the patients had a Mentzer Index at or below 13, indicating a much smaller subset in whom Hb electrophoresis was needed to rule out thalassemia trait. Conclusion: Although most of the children with anemia are secondary to iron deficiency Mentzer index should be determined in all patients of anemia so as to avoid inadvertently prescribing iron supplementation in cases of thalassemia trait.

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Section: Discussionsupporting

confidence: 92%

Haematological Profile and Mentzer Index in Pediatric Patients Presenting With Anemia

AGGARWAL,

MODI,

et al. 2024

Asian J Pharm Clin Res

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“…Additionally, a study comparing RDW and Mentzer index found a sensitivity of 94.2% and 99.4% and PPV of 98.8% and 97.7% for the diagnosis of IDA when compared with serum ferritin among primigravids in Pakistan [ 21 ]. During iron deficiency, smaller RBCs are produced by the bone marrow resulting in a smaller RBC count and low MCV, thus a Mentzer index of >13 [ 58 ]. Therefore, RDW and Mentzer index can be used for early presumptive diagnosis of IDA and thus early initiation of treatment to avert the complications and long-term sequelae associated with IDA.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Factors Associated with Iron Deficiency Anaemia among Children Aged 6-23 Months in Southwestern Uganda

Kajoba,

Egesa,

Muyombya

et al. 2024

International Journal of Pediatrics

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Iron deficiency anaemia is still a global public health concern with the highest burden among children 6 to 23 months due to their rapid growth spurt exceeding breastmilk supply. Therefore, nutritional supply is a key source of iron to attain the required nutrients for better growth and development. This was a cross-sectional descriptive study done at Ishaka Adventist Hospital (IAH) and Kampala International University Teaching Hospital (KIUTH) from April to July 2022. Participants were consecutively enrolled in the study. Structured questionnaires, 24-hour dietary recall, and clinical assessment were used to obtain data. Data analysis was done using the statistical package for social scientists (SPSS) V22.0. Bivariable and multivariable analyses were done using logistic regression for associations with significance set at P value < 0.05. A total of 364 participants were enrolled, with the majority being males (198, 54.4%) and born at term (333, 91.5%). The modal age was 12-17 months [163(44.8%)] with a mean age of 14.1 months (SD 5.32). The overall prevalence of IDA was 151/364 (41.5%). The factors associated with IDA included male sex (aOR 1.61), current episode of diarrhoea (aOR 1.71), poor meal frequency (aOR 1.78), no vegetable consumption (aOR 2.47), and consuming fruits once (aOR 1.97) in 7 days preceding the study. The study finds a high prevalence of IDA among infants 6-23 months with at least four in 10 being affected. Screening for IDA should be recommended in male children with current diarrhoea, poor intake of fruits and vegetables, and poor meal frequency. The Mentzer index is an equally good alternative screening test for IDA.

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“…During iron de ciency, smaller RBCs are produced by the bone marrow resulting in a smaller RBC count and low MCV thus a Mentzer index of >13 (Tabassum et al, 2022). Therefore, RDW and Mentzer index can be used for early presumptive diagnosis of IDA and thus early initiation of treatment to avert the complications and long-term sequelae associated with IDA.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with Iron deficiency anaemia among children aged 6-23 months in southwestern Uganda.

Dickson,

Egesa,

Muyombya

et al. 2024

Preprint

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Iron deficiency anemia is still a global public health concern with the highest burden among children 6 to 23 months due to their rapid growth spurt exceeding breastmilk supply. Therefore, nutritional supply is a key source of iron to attain the required nutrients for better growth and development. This was a cross-sectional descriptive study done at Ishaka Adventist Hospital (IAH) and Kampala International University Teaching Hospital (KIUTH) from April to July 2022. Participants were consecutively enrolled in the study. Structured questionnaires, 24-hour dietary recall, and clinical assessment were used to obtain data. Data analysis was done using the Statistical Package for Social scientists (SPSS) V22.0. Bivariable and multivariable analysis was done using logistic regression for associations with significance set at P-value <0.05. A total of 364 participants were enrolled, with majority males 198(54.4%) and born at term 333(91.5%). The modal age was 12-17 months [163(44.8%)] with a mean age of 14.1 months (SD 5.32). The overall prevalence of IDA was 151/364 (41.5%). The factors associated with IDA included male sex (aOR 1.61), current episode of diarrhoea (aOR 1.71), poor meal frequency (aOR 1.78), no vegetable consumption (aOR 2.47) and consuming fruits once (aOR 1.97) in 7 days preceding the study. The study finds a high prevalence of IDA among infants 6-23 months with at least four in 10 being affected. Screening for IDA should be recommended in male children with current diarrhea, poor intake of fruits and vegetables, and poor meal frequency. The Mentzer index is an equally good alternative screening test for IDA.

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Role of Mentzer index for differentiating iron deficiency anemia and beta thalassemia trait in pregnant women

Cited by 17 publications

References 16 publications

Haematological Profile and Mentzer Index in Pediatric Patients Presenting With Anemia

Haematological Profile and Mentzer Index in Pediatric Patients Presenting With Anemia

Prevalence and Factors Associated with Iron Deficiency Anaemia among Children Aged 6-23 Months in Southwestern Uganda

Prevalence and factors associated with Iron deficiency anaemia among children aged 6-23 months in southwestern Uganda.

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