Role of Mesenchymal Stem Cells (MSC) in HIV-1 Associated Bone and Lipid Toxicities

Cotter, Eoin J.; Maughan, Robert; Doran, Peter

doi:10.1007/978-94-007-4798-2_8

Cited by 3 publications

(4 citation statements)

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“…The above review provides not only new knowledge about the molecular mechanisms of stem cells pro-regenerative action, clinical trials based on the use of MSCs with complete status ( Gov, 2020a , Gov, 2020b , Gov, 2020c , Gov, 2020d , Gov, 2020e ), but also summarizes the so far published knowledge on the use of stem cells in the treatment of SARS-CoV-2 infection ( Chen, 2020 , Khatri et al, 2018 , Waszak et al, 2012 , Li et al, 2016 , Li et al, 2020 , Chan et al, 2016 , Curley et al, 2017 , Lee et al, 2011 , Weiss and Dahlke, 2019 , Harrell et al, 2020 , Harrell et al, 2019 , Costela-Ruiz et al, 2020 , Tan et al, 2020 , Raza and Khan, 2020 , Krasnodembskaya et al, 2010 , Johnson et al, 2017 , Chow et al, 2020 , Sutton et al, 2016 , Cotter et al, 2012 , Van Linthout et al, 2011 , Thanunchai et al, 2015 , Wu et al, 2018 , ClinicalTrials.gov, 2020 , Connick et al, 2012 , Wilson et al, 2014 , Saleh et al, 2020 , Inamdar and Inamdar, 2013 , Walter et al, 2014 , Anjos-Afonso et al, 2004 , Shetty, 2020 , Liang et al, 2020 , Sengupta et al, 2020 , Hassanpour et al, 2020 , Akbari and Rezaie, 2020 , Tsuchiya et al, 2020 , Sánchez-Guijo et al, 2020 , Chen et al, 2020 , Foronjy et al, 2014 , Metcalfe et al, 2015 , Metcalfe, 2020 , Shu et al, 2020 , Irmak et al, 2020 , Bonifazi et al, 2020 , Lee, 2018 , Musiał-Wysocka et al, 2019 , Verma et al, 2020 , Lukomska et al, 2019 ), and also effects of SARS-CoV-2 infection on lung epithelial stem cells ( …”

Section: Discussionmentioning

confidence: 97%

“…Stem cells are also used in viral infections: influenza virus, hepatitis B virus, human immunodeficiency virus and Coxsackie B3 virus ( Raza and Khan, 2020 , Cotter et al, 2012 , Van Linthout et al, 2011 , Thanunchai et al, 2015 , Wu et al, 2018 ). The mechanism of action of stem cells is to strengthen the immune system, reduce inflammation and the expression of interferons ( Cotter et al, 2012 , Van Linthout et al, 2011 , Thanunchai et al, 2015 , Wu et al, 2018 ).…”

Section: Stem Cells In Regenerative Medicine – Short Reviewmentioning

confidence: 99%

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Medical progress: Stem cells as a new therapeutic strategy for COVID-19

Musiał¹,

Górska‐Ponikowska²

2021

Stem Cell Research

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Currently, the world is facing the SARS-CoV-2 pandemic, coronavirus of acute respiratory distress syndrome 2, causes of COVID-19. Coronaviruses are RNA single-stranded viruses that have an envelope. In addition, coronaviruses are classified into four subfamilies: alpha, beta, gamma and delta coronaviruses. The first of them, cause mildly symptomatic or asymptomatic infections, while beta-coronaviruses are responsible for severe diseases. SARS-CoV-2 belongs to the group of beta-coronaviruses. Current available therapies use corticosteroids to reduce inflammation, non-specific antiviral drugs or antibiotics in the treatment of secondary bacterial infections. In addition, therapies based on the use of hydroxychloroquine, chloroquine, remdesvir, ribavirin, interferon or lopinavir-ritonavir were also initially used. Mesenchemical stem cells (MSCs) are widely used in cell therapies, which include both basic research and clinical trials. Their exceptional effectiveness and safety have been confirmed and documented in many clinical studies, which include a number of inflammatory diseases involving the immune system – one of them is systemic lupus erythematosus. Available data indicate the ability to differentiate MSCs and their immunomodulatory effects. In addition, through interactions with immune cells, which include, but are not limited to, macrophages and dendritic cells, or paracrine secretion, MSCs are able to secrete a number of types of cytokines. MSCs are also characterized by tissue regeneration and regulation of inflammation. Due to their properties, researchers turned to determine whether MSC transplantation is able to improve the outcome of patients with COVID-19 viral pneumonia. The presented review provides not only new knowledge in the field of molecular mechanisms of pro-regenerative action of stem cells, but also have the potential to open up new prospects of action to improve lung tissue regeneration in COVID-19 patients. In addition, in review mentioned about clinical trials using MSCs with a complete status, as well as the latest discoveries in molecular biology, a platform model of pluripotent stem cells in the SARS-CoV-2 study on 3D animal models and nanoconjugates based on stem cells.

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Section: Discussionmentioning

confidence: 97%

Section: Stem Cells In Regenerative Medicine – Short Reviewmentioning

confidence: 99%

Medical progress: Stem cells as a new therapeutic strategy for COVID-19

Musiał¹,

Górska‐Ponikowska²

2021

Stem Cell Research

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“…MSCs could express receptors that permit their infection by human immunodeficiency virus (HIV)-1 [47]. Highly active antiretroviral therapy (HAART) significantly decreases mortality and morbidity in patients with HIV-1 infection, but immune non-responders (INRs) with full viral suppression still fail to reverse the immune deficiency state [48].…”

Section: Mscs and Viral Infectionsmentioning

confidence: 99%

Mesenchymal Stem Cells — Their Antimicrobial Effects and Their Promising Future Role as Novel Therapies of Infectious Complications in High Risk Patients

Al-Anazi¹,

Al-Jasser²

2015

Progress in Stem Cell Transplantation

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“…SCs fight against viruses by specific gene expression like interferons, help in inflammation reduction and improve the immune system. Similar functions of SCs are used for the management of corona virus due to their immunomodulatory and reconstruction properties leading to the inhibition of infected lung tissue [ 15 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoconjugates-Based Stem Cell Therapy for the Management of COVID-19

Desai

Shende

2020

Stem Cell Rev and Rep

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A potential ability of stem cells (SCs) is to regenerate and repair tissues in the human body by providing great prospects for therapeutic applications in the field of medicine. Currently, SC therapy is used in various conditions like diabetes, neurodegenerative disorders, etc. but faces some limitations like patient biocompatibility and chances of cross-infection. SCs are further modulated with nanoconjugates to overcome such challenges and will offer an advantage in the treatment of COVID-19. This pandemic requires design and development of proper treatment to save the life of human beings. Advancements in SC-based nanoconjugated therapy will open new avenues and create a significant impact in the development of futuristic nanomedicine. It may also emerge as a potential therapy for the management of infection in patients suffering from SARS-CoV-2 and related diseases such as pneumonia and virus-induced lung injuries. Graphical abstract Mechanisms of stem cell-based nanoconjugates for inhibition of replication of corona virus.

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Role of Mesenchymal Stem Cells (MSC) in HIV-1 Associated Bone and Lipid Toxicities

Cited by 3 publications

References 34 publications

Medical progress: Stem cells as a new therapeutic strategy for COVID-19

Medical progress: Stem cells as a new therapeutic strategy for COVID-19

Mesenchymal Stem Cells — Their Antimicrobial Effects and Their Promising Future Role as Novel Therapies of Infectious Complications in High Risk Patients

Nanoconjugates-Based Stem Cell Therapy for the Management of COVID-19

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