The neonatal period may be defined as the first month of the calf's life; it may be considered part of the fourth trimester. It is the most hazardous due to the immaturity of the neonate's immune system and the environmental challenge from infections, the main causes of both bovine neonatal morbidity and mortality. The five most common morbidities causing mortality in neonatal calves are, in descending order, gastrointestinal infections, respiratory infections, abomasal disorders, umbilical infections and developmental abnormalities. This review describes the aetiology, incidence, risk factors and sequelae of these common morbidities and highlights current preventive strategies both at farm and national levels.