Role of methylenetetrahydrofolate reductase 677C-&gt;T polymorphism in the development of premature myocardial infarction

Rallidis, Lοukianos S.; Gialeraki, A.; Komporozos, Christoforos; Vavoulis, Panagiotis; Pavlakis, G.; Travlou, Αnthi; Lekakis, Ioannis; Kremastinos, Dimitrios Th.

doi:10.1016/j.atherosclerosis.2007.12.016

Cited by 34 publications

(26 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, only a few studies were done in young patients and the results are controversial [7,8]. To our knowledge, this is the first study analyzing the association between the C677T polymorphism in the MTHFR gene and idiopathic ischemic stroke in young adults in Mexico.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

The C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene Is Associated with Idiopathic Ischemic Stroke in the Young Mexican-Mestizo Population

Isordia‐Salas

Barinagarrementeria-Aldatz

Leaños‐Miranda³

et al. 2010

Cerebrovasc Dis

View full text Add to dashboard Cite

Background and Purpose: Previous studies have demonstrated that a common polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with an increased risk for stroke. However, this relation remains controversial. Our aim was to investigate the possible association between the C677T polymorphism in the MTHFR gene and idiopathic ischemic stroke in the young Mexican-Mestizo population. Methods: One hundred seventy-eight patients <45 years with idiopathic ischemic stroke and 183 controls were tested for the C677T polymorphism in the MTHFR gene. Causes of primary thrombophilia as well as classical risk factors for atherothrombotic disease were also evaluated. Results: There was a significant difference in the genotype distribution between patients and controls (p = 0.01), but the allele frequency was similar in both groups (p = 0.09). The univariate analysis identified the T allele as a risk factor for ischemic stroke (TT and CT carriers), as compared with homozygous for C allele (p = 0.01). Hypertension and smoking prevalences were significantly higher in the group of patients. Also the T allele was significantly associated with large-vessel ischemic stroke. The postoral methionine load homocysteine levels were higher in patients with ischemic stroke versus controls (p < 0.001). There was a low prevalence of primary thrombophilia markers. Conclusions: The T allele from the C677T polymorphism of the MTHFR gene represents an independent risk factor for idiopathic ischemic stroke at young age in the Mexican-Mestizo population. Also, hypertension and smoking were independent risk factors in our study population. Primary thrombophilic risk factors were not associated with ischemic stroke in our population.

show abstract

Section: Discussionmentioning

confidence: 95%

“…5,10-methylenetetrahydrofolate reductase (MTHFR) plays a critical role in Hcy metabolism [3]. Earlier studies identified a common polymorphism (C677T) in the gene encoding the MTHFR as a genetic risk factor for premature stroke [3,4,5,6] and coronary artery disease [7]. However, these findings have not always been confirmed [8,9].…”

Section: Introductionmentioning

confidence: 89%

The C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene Is Associated with Idiopathic Ischemic Stroke in the Young Mexican-Mestizo Population

Isordia‐Salas

Barinagarrementeria-Aldatz

Leaños‐Miranda³

et al. 2010

Cerebrovasc Dis

View full text Add to dashboard Cite

show abstract

“…20 This result may be due to the higher homocysteine levels usually detected in carriers of homozygous TT variation, which correlates with cardiovascular risk. 21, 22 Interestingly, in our population we observed higher homocysteine levels in the ST rather than the non-ST group, despite similar genotype and allele frequencies of C677T-MTHFR polymorphism. Even if these data are not supported by a larger sample size, they suggest a potential role of homocysteine even in the complex pathogenesis of ST.…”

Section: Discussionmentioning

confidence: 69%

Prevalence of Inherited Thrombophilia in Patients With Documented Stent Thrombosis

Zavalloni

Presbitero

Lodigiani

et al. 2012

Circ J

View full text Add to dashboard Cite

“…Mutations in C677T and A1298C alleles are the two common MTHFR polymorphisms and are related to increased premature MI and premature coronary artery disease (3,4). Mutations in C677T allele are characterized by a reduced enzyme activity, a mild elevation of plasma homocysteine, and low plasma folate level whereas mutations in A1298C allele seem to rather affect regulatory properties of the enzyme without causing hyperhomocysteinemia (5).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Acute Coronary Syndromes With Normal Homocystein Level: An Uncommon Mutation of MTHFR Gene

Guler¹

2014

GMJ

View full text Add to dashboard Cite

A 29-year-old female patient, complaining of squeezing retrosternal chest pain, was admitted to our emergency department. Her angina pectoris had started fifteen days ago and accentuated during the last two days. In her medical history, it was determined that during the last four years she had been admitted to hospitals with the same complaint twice, troponins were found to be elevated, she was hospitalized and coronary angiography (CAG) was totally normal. The young woman with recurrent acute coronary syndrome had a mutation in the MTHFR gene.

show abstract

Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction

Cited by 34 publications

References 31 publications

The C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene Is Associated with Idiopathic Ischemic Stroke in the Young Mexican-Mestizo Population

The C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene Is Associated with Idiopathic Ischemic Stroke in the Young Mexican-Mestizo Population

Prevalence of Inherited Thrombophilia in Patients With Documented Stent Thrombosis

Recurrent Acute Coronary Syndromes With Normal Homocystein Level: An Uncommon Mutation of MTHFR Gene

Contact Info

Product

Resources

About