Role of micronutrients in Alzheimer's disease: Review of available evidence

Hong-xin, Fei; Qian, Chao-Fan; Wu, Xiangbing; Wei, Yuhua; Huang, Jinyu; Wei, Lihua

doi:10.12998/wjcc.v10.i22.7631

Cited by 7 publications

(3 citation statements)

References 100 publications

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“…Silica may protect against AD development by reducing the transport of toxic substances to the brain. Silica may reduce the absorption of aluminum and therefore reduce the risk of developing AD [ 30 , 31 ]. Calcium has been found to have a protective role in AD development, while oversupplementation of calcium has also been shown to increase the risk of AD.…”

Section: Discussionmentioning

confidence: 99%

Association between the Composition of Drinking Water and Cognitive Function in the Elderly: A Systematic Review

Wasick,

Kim

2024

IJERPH

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The prevalence of dementia increases with nearly 10 million new cases each year, with Alzheimer’s disease contributing to 60–70% of cases. Environmental factors such as drinking water have been evaluated to determine if a relationship exists between trace elements in drinking water and the risk of developing cognitive disorders in the elderly. The purpose of the current systematic review was to evaluate an association between the composition of drinking water and cognitive function in the elderly. In accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines, a literature search was conducted using PubMed and CINAHL databases. A total of 10 studies were included in the current systematic review. Aluminum is the most commonly evaluated trace element in studies (n = 8), followed by silica (n = 5), calcium (n = 4), and fluoride (n = 4). Aluminum exposure showed an increased risk of cognitive decline in four studies, with no association reported in the other studies. Higher silica and pH levels were shown to be protective against a decline in cognitive function. A similar protective effect of calcium was found in two studies. Future research should measure multiple trace mineral levels in all water sources to evaluate the impact on cognitive function.

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Section: Discussionmentioning

confidence: 99%

Association between the Composition of Drinking Water and Cognitive Function in the Elderly: A Systematic Review

Wasick,

Kim

2024

IJERPH

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“…Copper is needed for the activity of cytochrome oxidase, which is important for brain function. People with Alzheimer's disease have lower levels of copper in their brain [29,30,31].…”

Section: Coppermentioning

confidence: 99%

Metal toxicity exposure in Alzheimer's disease - literature review

Jakubowska,

Hoppe-Mitera,

Sionek

et al. 2024

J Educ Health Sport

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Introduction and purpose: As the elderly population grows, the risk of cognitive decline and dementia increases. Environmental toxicants, including metals, have been identified as potential contributors to these conditions. This literature review investigated the potential contribution of metals, such as aluminium, lead, zinc and copper to Alzheimer's disease development.Material and methods: The literature was conducted using "Pub Med" and "Google Scholar" databases with the keywords "metals", "Alzheimer's disease", "aluminium", "lead", "neurodegenerative diseases", "copper".Brief description of the state of knowledge: Metals can negatively affect the functionality of the central nervous system, leading to impairments in behavior, motor skills, and cognitive abilities. The development of Alzheimer's disease can be influenced by several factors, including Aβ aggregates, tau tangles, synaptic dysfunction, inflammation, and oxidative stress, which may be worsened by interactions with these metals.Results and conclusions: Extensive research has shown a link between metal exposure and neurodegeneration. Understanding the role of metals like lead, copper, aluminum, and zinc in Alzheimer's disease pathogenesis remains crucial, but further investigation is needed. A better insight into the impact of metal exposure on brain health could help find the way for effective prevention and treatment strategies for neurodegenerative diseases.

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“…The role of abnormal homeostasis of several micronutrients in AD progression is also known. Especially significant are lower plasmatic levels of vitamins A, B, C, D, and E, and Se, Cu, Zn, and increased levels of homocysteine (Hcy) [12][13][14][15].…”

Section: Micronutrients-roles Levels Administration: Current Knowledgementioning

confidence: 99%

The Role of Micronutrients in Neurological Disorders

Lahoda Brodska,

Klempir,

Zavora

et al. 2023

Nutrients

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Trace elements and vitamins, collectively known as micronutrients, are essential for basic metabolic reactions in the human body. Their deficiency or, on the contrary, an increased amount can lead to serious disorders. Research in recent years has shown that long-term abnormal levels of micronutrients may be involved in the etiopathogenesis of some neurological diseases. Acute and chronic alterations in micronutrient levels may cause other serious complications in neurological diseases. Our aim was to summarize the knowledge about micronutrients in relation to selected neurological diseases and comment on their importance and the possibilities of therapeutic intervention in clinical practice.

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Role of micronutrients in Alzheimer's disease: Review of available evidence

Cited by 7 publications

References 100 publications

Association between the Composition of Drinking Water and Cognitive Function in the Elderly: A Systematic Review

Association between the Composition of Drinking Water and Cognitive Function in the Elderly: A Systematic Review

Metal toxicity exposure in Alzheimer's disease - literature review

The Role of Micronutrients in Neurological Disorders

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