Role of microRNA and long non-coding RNA in Marek's disease tumorigenesis in chicken

Zhang, Zhaobo; Zhang, Sishi; Wang, Guoshuai; Feng, Siyu; Han, Kexin; Han, Limei; Han, Liping

doi:10.1016/j.rvsc.2021.01.007

Cited by 7 publications

(5 citation statements)

References 102 publications

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“…Three major species: pig, chicken, and cow* Muscle Growth performance and meat quality Pig (J. Sun et al 2017 ; Zou et al 2017a , b ; Zou et al 2017a , b ; Li et al 2020 ) Chicken (Li et al 2012 ; Li et al 2019 ; Ren et al 2018a , b ; Cai et al 2017 ) Cow (Choi et al 2019 ; Li et al 2020 ) Mammary gland Milk production and quality Cow (Tong et al 2017 ; Yang et al 2018 ; Ibeagha-Awemu et al 2018 ; Zeng et al 2019 ) Immunity tissues Disease or resistance against pathogenic infections Pig (Fang et al 2019 ) Chicken (Qiu et al 2017 ; Hu et al 2018 ; Ren et al 2018a , b ; You et al 2019 ; Dai et al 2019 ; Li et al 2021 ; Zhang et al 2021 ) Cow (Özdemir and Altun 2020 ) Male sexual organs Male reproduction traits Pig (Esteve-Codina et al 2011 ) Chicken (Liu et al …”

Section: De Novo Transcriptome Reconstruction Of New Long Non-coding ...mentioning

confidence: 99%

LncRNAs in domesticated animals: from dog to livestock species

et al. 2021

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Animal genomes are pervasively transcribed into multiple RNA molecules, of which many will not be translated into proteins. One major component of this transcribed non-coding genome is the long non-coding RNAs (lncRNAs), which are defined as transcripts longer than 200 nucleotides with low coding-potential capabilities. Domestic animals constitute a unique resource for studying the genetic and epigenetic basis of phenotypic variations involving protein-coding and non-coding RNAs, such as lncRNAs. This review presents the current knowledge regarding transcriptome-based catalogues of lncRNAs in major domesticated animals (pets and livestock species), covering a broad phylogenetic scale (from dogs to chicken), and in comparison with human and mouse lncRNA catalogues. Furthermore, we describe different methods to extract known or discover novel lncRNAs and explore comparative genomics approaches to strengthen the annotation of lncRNAs. We then detail different strategies contributing to a better understanding of lncRNA functions, from genetic studies such as GWAS to molecular biology experiments and give some case examples in domestic animals. Finally, we discuss the limitations of current lncRNA annotations and suggest research directions to improve them and their functional characterisation.

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Section: De Novo Transcriptome Reconstruction Of New Long Non-coding ...mentioning

confidence: 99%

LncRNAs in domesticated animals: from dog to livestock species

et al. 2021

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“…This indicated that the overexpression of miR-106a-5p attenuated retinal in ammatory responses and suppressed the expression of VEGF and HIF-1α. VEGF and HIF-1α are two key factors that promote angiogenesis [12] , and reducing their expression can effectively reduce angiogenesis, thereby controlling the occurrence and development of ROP.…”

Section: Overexpression Of Mir-106a-5p Suppresses Apoptosis and In Am...mentioning

confidence: 99%

“…MALAT1 can upregulate VEGF-A expression by inhibiting miR-140, thereby promoting angiogenesis in endothelial cells. MiRNAs are endogenous small non-coding RNA molecules, which could regulate the expression of its target mRNAs by binding to their 3′-untranslated region (3′UTR) [12] . As a member of the neutral zinc protease family, MMP-2 have been implicated in a wide range of physiological and pathological processes, including wound healing, angiogenesis, in ammation, and tumor metastases [13,14] .…”

Section: Introductionmentioning

confidence: 99%

Long-chain non-coding RNA MALAT1 upregulates the MMP-2 signaling pathway by inhibiting miR-106a-5p in murine oxygen- induced retinopathy

et al. 2022

Preprint

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Retinopathy of prematurity (ROP) is a blinding eye disease in children that is characterized by the formation of neovascularization in the retina; current treatments for this disease risk retinal damage and visual impairment. This study aimed to investigate the relationship between metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), miR-106a-5p, and matrix metalloproteinase 2 (MMP-2) in an oxygen-induced retinopathy mouse model and hypoxia-induced human retinal endothelial cells and to elucidate whether MALAT1 upregulates MMP-2 signaling by inhibiting miR-106a-5p. The role of this pathway in oxygen-induced murine retinopathy and its underlying mechanism were also investigated. MALAT1 inhibited the expression of miR-106a-5p and enhanced the expression of MMP-2, which in turn caused a series of pathological changes, such as the formation of new blood vessels in the retina. In addition, knockdown of MALAT1 can downregulate the expression of MMP-2 by sponging miR-106a-5p and inhibiting cell proliferation, migration, and tube-forming ability. In conclusion, our findings suggest that MALAT1 may contribute to the occurrence and development of ROP by inhibiting miR-106a-5p and increasing the expression of MMP-2, thus providing a new perspective for the targeted therapy of ROP.

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“…Live attenuated vaccination is still used worldwide at this stage in the prevention of MD (5). However, the widespread use of the vaccine has also led to the increased virulence of MDV, from a strong strain (vMDV) in the 1970s that broke through the contemporaneous turkey herpesvirus (HVT) vaccine, to a super-virulent strain (vvMDV) in the 1980s, and then to an very virulent plus (vv+MDV) in the 1990s that also broke through the protection of vaccines such as bivalent vaccines HVT+MDV2 (SB1) (6). The emergence of extra-virulent viruses and the increased virulence of wild strains have emerged as the major main challenges to the sustained control of this disease, causing considerable harm to livestock and economic losses in the poultry farming industry (7,8).…”

Section: Introductionmentioning

confidence: 99%

Role of gga-miR-29b-3p in suppressing the proliferation, invasion and migration of MSB1 Marek’s disease tumor cells by the targeting of the DNMT3B gene

Han¹,

Lian²,

Ren³

et al. 2022

Ann Transl Med

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Background: Marek's disease (MD), a class II infectious, lymphoproliferative disease that mainly afflicts poultry, has been shown to cause wasting, limb paralysis, and often acute death. It is a neoplastic disease caused by a cell-binding herpesvirus that leads to the formation of tumors in various organs and tissues. Our previous reports have found that the microRNA, gga-miR-29b-3p, showed abnormal expression in MD lymphoma. However, it remains unknown whether gga-miR-29b-3p affects MD tumorigenesis. Methods:The MD tumor cell line MSB1 was chosen to analyze the characteristics of gga-miR-29b-3p in tumors. Cell proliferation and migration were assessed by Cell Counting Kit-8 (CCK-8) and Transwell, respectively, and cell apoptosis and cycle were analyzed via fluorescent staining and flow cytometry, respectively. The regulation between gga-miR-29b-3p and its potential target genes was verified by dual luciferase results and loss-of-function assays. The effect of target genes was verified by examining the degree of RNA interference on MSB1 cells.Results: Analysis revealed that gga-miR-29b-3p impaired the proliferation of the MSB1 MD tumor cell line, induced apoptosis without obvious effects on the cell cycle, and suppressed the expression of the invasion-associated MMP2 and MMP9 genes. It was concluded that DNMT3B is the direct target of gga-miR-29b-3p. As expected, the effects of DNMT3B knockdown with small interfering RNA (siRNA) on MSB1 cell proliferation, apoptosis, and cycle were associated with gga-miR-29b-3p overexpression.Moreover, BCL2 and BCL2L1 were downregulated and TNFSF10 was upregulated in both the gga-miR-29b-3p overexpression and DNMT3B knockdown groups. The expression levels of invasion-related genes were decreased post-DNMT3B knockdown. In both the gga-miR-29b-3p overexpression and DNMT3B knockdown conditions, a decrease in MEQ oncogene expression in MD virus was observed.Conclusions: Overall, gga-miR-29b-3p was demonstrated to have a suppressive effect in MD lymphoma progression via the targeting of the DNMT3B gene. Gga-miR-29b-3p overexpression and DNMT3B knockdown inhibited MSB1 cell proliferation through suppressing the pro-apoptotic gene expression and elevating the anti-apoptotic gene expression in the apoptosis pathway. Our study provides a theoretical basis for targeted treatment of MD.

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Role of microRNA and long non-coding RNA in Marek's disease tumorigenesis in chicken

Cited by 7 publications

References 102 publications

LncRNAs in domesticated animals: from dog to livestock species

LncRNAs in domesticated animals: from dog to livestock species

Long-chain non-coding RNA MALAT1 upregulates the MMP-2 signaling pathway by inhibiting miR-106a-5p in murine oxygen- induced retinopathy

Role of gga-miR-29b-3p in suppressing the proliferation, invasion and migration of MSB1 Marek’s disease tumor cells by the targeting of the DNMT3B gene

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