Role of microRNA in melanoma progression

Kunz, M.; Schultz, James E.; Ibrahim, Sa’adatu M.

doi:10.1097/00008390-200609001-00095

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A more elevated abnormal expression of miRNA-21 in chronic lymphatic leukemia, hepatic tumor, tumors of the neck and face, and human osteosarcoma was found. Kunz et al [10] found that in patients of metastatic melanoma, in comparison to the non-treatment control group and under different treatment approaches, the expression of miRNA-21 was down-regulated after treatment. This study was the first to report where miRNA responded to chemotherapy and was a key factor in the pathogenic mechanism of melanoma.…”

Section: Discussionmentioning

confidence: 99%

The miRNA expression profile of the uveal melanoma

Yang

Wei

2011

Sci. China Life Sci.

View full text Add to dashboard Cite

The miRNA expression profile was initially established to investigate its corresponding function in human uveal melanoma. The miRNA expression profile in human uveal melanoma was analyzed by a micro chip technique. The hsa-miRNA expression between four uveal melanomas and four normal uveal tissues was compared. Based on the bioinformatic approach, chip data was analyzed to select out differentially expressed candidate hsa-miRNAs. Real-time quantitative PCR (RT-PCR) was used to confirm the candidate hsa-miRNAs expression in all samples. The results of miRNA microarray chips that matched with RT-PCR were considered as the miRNA expression which was significantly different between normal tissue and uveal melanomas. In four uveal melanomas, expressions of miRNA-20a, miRNA-106a, miRNA-17, miRNA-21, and miRNA-34a were significantly up-regulated, while miRNA-145 and miRNA-204 expression were significantly down-regulated. We used miRNA microarray analysis as a fast, efficient technology to study biological information. The differentially expressed miRNAs may be involved in uveal melanoma pathogenesis, and may help promote the diagnosis and treatment for uveal melanoma.

show abstract

Section: Discussionmentioning

confidence: 99%