Role of MicroRNAs in Malignant Glioma

Wang, Baocheng; Ma, Jie

doi:10.4103/0366-6999.156141

Cited by 49 publications

(30 citation statements)

References 66 publications

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“…MicroRNAs are small noncoding RNAs, which usually serve as antisense regulators of gene expression . Increasing evidence revealed that miRNAs were abnormally expressed in various cancers, including glioma . miRNA expression profiling has been reported to affect the function of genes involved in tumorigenesis, proliferation, and apoptosis in glioma .…”

Section: Introductionmentioning

confidence: 99%

“…miRNA expression profiling has been reported to affect the function of genes involved in tumorigenesis, proliferation, and apoptosis in glioma . Recently, microarray studies on miRNAs have shown significant changes of expression in malignant gliomas, including miR‐7, miR‐153, miR‐21, miR‐34a, miR‐128, and so on . Among them, miR‐182 has been shown to be a prognostic indicator of glioma progression and patient survival .…”

Section: Introductionmentioning

confidence: 99%

“…10 Increasing evidence revealed that miRNAs were abnormally expressed in various cancers, including glioma. 11,12 miRNA expression profiling has been reported to affect the function of genes involved in tumorigenesis, proliferation, and apoptosis in glioma. 13 Recently, microarray studies on miRNAs have shown significant changes of expression in malignant gliomas, including miR-7, miR-153, miR-21, miR-34a, miR-128, and so on.…”

mentioning

confidence: 99%

“…13 Recently, microarray studies on miRNAs have shown significant changes of expression in malignant gliomas, including miR-7, miR-153, miR-21, miR-34a, miR-128, and so on. 12,[14][15][16][17][18] Among them, miR-182 has been shown to be a prognostic indicator of glioma progression and patient survival. 19 Previous studies have indicated that miR-128 might be potential cancer suppressors in different types of glioma, such as neuroblastoma and glioblastoma.…”

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confidence: 99%

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miR‐128‐3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1

Yan

Cao

et al. 2019

IUBMB Life

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Glioma, like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect, which is a dominant phenotype of most tumor cells. Glioma tumors exhibit high glycolytic metabolism with increased lactate production. Data derived from the gene expression profiling interactive analysis (GEPIA) database show that pyruvate dehydrogenase kinase 1 (PDK1) is significantly highly expressed in glioma tissues compared with corresponding normal tissues. PDK1 is a key enzyme in the transition of glycolysis to tricarboxylic acid cycle, via inactivating PDH and converting oxidative phosphorylation to Warburg effect, resulting in increment of lactate production. Silencing of PDK1 expression resulted in reduced lactate and ATP, accumulation of ROS, mitochondrial damage, decreased cell growth, and increased cell apoptosis. Aberrant expression of miR‐128 has been observed in many human malignancies. Mechanistically, we discover that overexpressed miR‐128‐3p disturbs the Warburg effect in glioma cells via reducing PDK1. Our experiments confirmed that the miR‐128‐3p/PDK1 axis played a pivotal role in cancer cell metabolism and growth. Collectively, these findings suggest that therapeutic strategies to modulate the Warburg effect, such as targeting of PDK1, might act as a potential therapeutic target for glioma treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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miR‐128‐3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1

Yan

Cao

et al. 2019

IUBMB Life

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“…As there are so many reports dealing the miRNAs which can play a role in the glioma biology (Table 3) [30], it was impossible for our results to be validated by the previously reported data in the gliomas.…”

Section: Limitations Of the Studymentioning

confidence: 64%

Analysis of microRNA expression in glial tumors by using a peptide nucleic acid-based microarray

Kim

2019

Precis Future Med

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Purpose: Glial tumors are the most common primary brain tumors. However, their characteristics and prognosis are difficult to discern. There is currently an emphasis on microRNAs (miRNA) as candidate biomarkers for glial tumors. The aim of this study is to identify the specific miRNA patterns in glial tumors by using peptide nucleic acid (PNA)based microarrays in an assortment of glial tumors and normal tissue samples. Methods: Sample files were retrospectively assessed for cases diagnosed as glial tumors at the pathological archives of two institutes. miRNAs of 28 cases of glial tumors were analyzed by microarray. In order to verify the results, quantitative real-time polymerase chain reaction (RT-PCR) was performed. miRNA expression was calculated using the 2-ΔΔCT method. The expression level of the miRNAs was compared using SPSS version 20.0 (IBM Co.). Results: miRNA expression profiling of glial tumors revealed that 62 miRNAs were detected from glioblastoma and benign brain tissue, with different expression patterns. The expression of miR-296-3p, miR-370, and miR-371-5p was shown to be involved in malignancy. These miRNAs were also increased in the glioblastoma with methylated O6-methyguanine DNA methyltransferase. The expression pattern of miR-296-3p shows same tendency in PNA-based microarray and RT-PCR. Conclusion: These analyses suggest that novel miRNAs can be applicable as diagnostic tools and target therapeutic agents, since miRNAs can positively or negatively regulate glioblastomas.

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Unraveling the signaling mechanism behind astrocytoma and possible therapeutics strategies: A comprehensive review

Nahar Metu,

Sutihar,

Sohel

et al. 2023

Cancer Reports

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BackgroundA form of cancer called astrocytoma can develop in the brain or spinal cord and sometimes causes death. A detailed overview of the precise signaling cascade underlying astrocytoma formation has not yet been revealed, although various factors have been investigated. Therefore, our objective was to unravel and summarize our current understanding of molecular genetics and associated signaling pathways with some possible therapeutic strategies for astrocytoma.Recent FindingsIn general, four different forms of astrocytoma have been identified in individuals, including circumscribed, diffuse, anaplastic, and multiforme glioblastoma, according to a recent literature review. All types of astrocytoma have a direct connection with some oncogenic signaling cascade. Common signaling is MAPK cascade, including Ras‐Raf‐ERK, up‐regulated with activating EGFR/AKT/PTEN/mTOR and PDGFR. Recent breakthrough studies found that BRAF mutations, including KIAA1549: BRAF and BRAF V600E are responsible for astrocytoma progression. Additionally, cancer progression is influenced by mutations in some tumor suppressor genes, such as the Tp53/ATRX and MGMT mutant. As synthetic medications must cross the blood–brain barrier (BBB), modulating signal systems such as miRNA is the primary option for treating patients with astrocytoma. However, available surgery, radiation therapy, and experimental therapies such as adjuvant therapy, anti‐angiogenic therapy, and EGFR‐targeting antibody drug are the usual treatment for most types of astrocytoma. Similar to conventional anticancer medications, some phytochemicals slow tumor growth by simultaneously controlling several cellular proteins, including those involved in cell cycle regulation, apoptosis, metastatic spread, tyrosine kinase, growth factor receptor, and antioxidant‐related proteins.ConclusionIn conclusion, cellular and molecular signaling is directly associated with the development of astrocytoma, and a combination of conventional and alternative therapies can improve the malignancy of cancer patients.

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Role of MicroRNAs in Malignant Glioma

Cited by 49 publications

References 66 publications

miR‐128‐3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1

miR‐128‐3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1

Analysis of microRNA expression in glial tumors by using a peptide nucleic acid-based microarray

Unraveling the signaling mechanism behind astrocytoma and possible therapeutics strategies: A comprehensive review

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