2017
DOI: 10.4331/wjbc.v8.i1.45
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Role of microRNAs in translation regulation and cancer

Abstract: MicroRNAs (miRNAs) are pervasively expressed and regulate most biological functions. They function by modulating transcriptional and translational programs and therefore they orchestrate both physiological and pathological processes, such as development, cell differentiation, proliferation, apoptosis and tumor growth. miRNAs work as small guide molecules in RNA silencing, by negatively regulating the expression of several genes both at mRNA and protein level, by degrading their mRNA target and/or by silencing … Show more

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Cited by 356 publications
(249 citation statements)
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References 138 publications
(137 reference statements)
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“…The aberrant regulation of SNAI1 has been found to be involved in the metastasis and invasion of GC via regulating the EMT process (Liu et al, ). MicroRNAs (miRNAs) are a family of endogenous, small (approximately 22 nucleotides in length), noncoding, functional RNAs, which regulate a vast number of protein‐coding genes, including tumor‐related genes (Oliveto, Mancino, Manfrini, & Biffo, ; Svoronos, Engelman, & Slack, ). We have previously found that miR‐128b suppresses tumor growth and promotes apoptosis in GC (Wang et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…The aberrant regulation of SNAI1 has been found to be involved in the metastasis and invasion of GC via regulating the EMT process (Liu et al, ). MicroRNAs (miRNAs) are a family of endogenous, small (approximately 22 nucleotides in length), noncoding, functional RNAs, which regulate a vast number of protein‐coding genes, including tumor‐related genes (Oliveto, Mancino, Manfrini, & Biffo, ; Svoronos, Engelman, & Slack, ). We have previously found that miR‐128b suppresses tumor growth and promotes apoptosis in GC (Wang et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…20 It has been demonstrated that miRNAs are widely involved in cell proliferation, differentiation, apoptosis, and cell cycle regulation. 22 And the lncRNA can bind to the functional sequence of DEmRNAs contained in the lncRNA-miRNA-mRNA network and all defined DEmRNAs, respectively. 22 And the lncRNA can bind to the functional sequence of DEmRNAs contained in the lncRNA-miRNA-mRNA network and all defined DEmRNAs, respectively.…”
Section: Discussionmentioning
confidence: 99%
“…In recent decades, various roles of miRNAs have been explored in diverse physiological and pathological activities, including tumorigenesis [17-21]. For instance, miR-34a has been observed to mediate multiple cancerous pathways by targeting crucial genes in tumorigenesis including P53, PDGFR, and c-MET, etc [22].…”
Section: Discussionmentioning
confidence: 99%