Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review)

Abstract

Pre-eclampsia (PE) is a complicated pregnancy-specific disease and is considered the primary reason for maternal and foetal mortality and morbidity. PE has a multifactorial pathogenesis but the causes of PE remain unclear. The functions of trophoblasts, including differentiation, proliferation, migration, invasion and apoptosis, are essential for successful pregnancy. During the early stages of placental development, trophoblasts are strictly regulated by several molecular pathways; however, an imbalance of these molecular pathways can lead to severe placental lesions and pregnancy complications. Certain microRNAs (miRs) are abnormally expressed in PE, with several miRs involved in the regulation of pregnancy-associated genes. The present review discusses the miRs regulating trophoblast function, how they affect the pathogenesis of PE and evaluating the possibility of miRs in screening, diagnosis and treatment of PE. Contents1. Introduction 2. Biological characteristics and production of miRs 3. miRs are expressed in PE 4. miRs regulate the activity of trophoblasts 5. miRs regulate the stress response of trophoblasts 6. Applications of miRs in PE 7.