Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

Dubey, Pallavi; Thakur, Vikram; Chattopadhyay, Munmun

doi:10.3390/nu12061864

Cited by 265 publications

(192 citation statements)

References 123 publications

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“…[ 10 , 22 ]. Similarly, oral Zn supplementation could not improve diabetic neuropathy, oxidative stress, or vascular function in patients with type 2 diabetes [ 23 , 24 ]. Additionally, studies related to Zn and MetS are scarce and inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Lee

Kuo

et al. 2021

Nutrients

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The association between serum concentrations of zinc, copper, or iron and the risk of metabolic syndrome are inconclusive. Therefore, we conduct a case-control study to explore the relationship between serum levels of zinc, copper, or iron and metabolic syndrome as well as each metabolic factor and insulin resistance. We enrolled 1165 adults, aged ≥ 40 (65.8 ± 10) years in a hospital-based population to compare the serum levels of zinc, copper, and iron between subjects with and without metabolic syndrome by using multivariate logistic regression analyses. The least square means were computed by general linear models to compare serum concentrations of zinc, copper, and iron in relation to the number of metabolic factors. The mean serum concentrations of zinc, copper, and iron were 941.91 ± 333.63 μg/L, 1043.45 ± 306.36 μg/L, and 1246.83 ± 538.13 μg/L, respectively. The odds ratios (ORs) of metabolic syndrome for the highest versus the lowest quartile were 5.83 (95% CI: 3.35–10.12; p for trend < 0.001) for zinc, 2.02 (95% CI: 1.25–3.25; p for trend: 0.013) for copper, and 2.11 (95% CI: 1.24–3.62; p for trend: 0.021) for iron after adjusting for age, sex, personal habits, body mass index, and homeostatic model assessment insulin resistance. Additionally, the serum zinc, copper, and iron concentrations increased as the number of metabolic factors rose (p for trend < 0.001). This was the first study to clearly demonstrate that higher serum levels of zinc, copper, and iron were associated with the risk of metabolic syndrome and the number of metabolic factors independent of BMI and insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Lee

Kuo

et al. 2021

Nutrients

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“…Few studies have focused on the associations of cobalt with IR and type 2 diabetes. The review by Dubey et al summarized existing research on cobalt concentrations in diabetic patients; however, there is not enough research currently, and the existing research has produced inconsistent conclusions [20]. Cao et al found that elevated or decreased plasma cobalt levels were associated with a high risk of type 2 diabetes [21].…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the link between blood cobalt concentrations and insulin resistance in adults without diabetes

Chen

Huang

et al. 2021

Environ Health Prev Med

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Background Little is known about the effects of environmental cobalt exposure on insulin resistance (IR) in the general adult population. We investigated the association between cobalt concentration and IR. Methods A total of 1281 subjects aged more than 20 years with complete blood cobalt data were identified from the National Health and Nutrition Examination Survey (NHANES) 2015–2016 cycle. Blood cobalt levels were analyzed for their association with IR among all populations and subgroups by sex. Regression coefficients and 95% confidence intervals (CIs) of blood cobalt concentrations in association with fasting glucose, insulin and homeostatic model assessment of insulin resistance (HOMA-IR) were estimated using multivariate linear regression after adjusting for age, sex, ethnicity, alcohol consumption, body mass index, education level, and household income. A multivariate generalized linear regression analysis was further carried out to explore the association between cobalt exposure and IR. Results A negative association between blood cobalt concentration (coefficient = − 0.125, 95% CI − 0.234, − 0.015; P = 0.026) and HOMA-IR in female adults in the age- and sex-adjusted model was observed. However, no associations with HOMA-IR, fasting glucose, or insulin were found in the overall population. In the generalized linear models, participants with the lowest cobalt levels had a 2.74% (95% CI 0.04%, 5.50%) increase in HOMA-IR (P for trend = 0.031) compared with subjects with the highest cobalt levels. Restricted cubic spline regression suggested that a non-linear relationship may exist between blood cobalt and HOMA-IR. Conclusions These results provide epidemiological evidence that low levels of blood cobalt are negatively associated with HOMA-IR in female adults.

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“…Disturbance of Zn homeostasis is related to various disorders. Its role in metabolic syndrome and diabetic implications has been discussed in detail [ 116 , 117 ]. Enzymes involved in cell membrane stabilization or required for metabolism of neurotransmitters, melatonin [ 118 ] and prostaglandins are using zinc as cofactor.…”

Section: Zinc (Zn)mentioning

confidence: 99%

Magnesium, Iron, Zinc, Copper and Selenium Status in Attention-Deficit/Hyperactivity Disorder (ADHD)

et al. 2020

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In this study, we critically review the literature concerning the relation of Mg, Fe, Zn, Cu and Se and attention-deficit/hyperactivity disorder (ADHD). Elemental status is estimated using peripheral blood parameters, hair, urine, daily intake and response to supplementation. The observed associations between concentration levels of the elements Mg, Fe, Zn, Cu and Se and ADHD symptoms are contradictory. This is partly due to the heterogeneity and complexity of the disorder. As a trend, lower ferritin and zinc levels can be observed. However, this correlation is not causative, as illustrated by placebo-controlled trials reporting conflicting evidence on the efficacy of supplementation. Well-defined studies on changes in concentration levels of the elements in relation to ADHD symptoms before and after treatment with therapeutics it will be possible to shed more light on the significance of these elements in this behavioral disorder. The discussion on whether a change in concentration of an element is cause or consequence of ADHD is not within the scope of this article.

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Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

Cited by 265 publications

References 123 publications

Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Sex differences in the link between blood cobalt concentrations and insulin resistance in adults without diabetes

Magnesium, Iron, Zinc, Copper and Selenium Status in Attention-Deficit/Hyperactivity Disorder (ADHD)

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