Role of miRNA in cancer diagnosis, prognosis, therapy and regulation of its expression by Epstein–Barr virus and human papillomaviruses: With special reference to oral cancer

Chawla, Jatinder Pal Singh; Iyer, Nageshwar; Soodan, Kanwaldeep Singh; Sharma, Atul; Khurana, Sunpreet Kaur; Priyadarshni, Pratiksha

doi:10.1016/j.oraloncology.2015.05.008

Cited by 53 publications

(38 citation statements)

References 83 publications

(87 reference statements)

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“…4 MicroRNAs (miRNAs) are noncoding RNAs that downregulate the expression of targeted genes by binding to the specific sequences in the 3 0 untranslated region (UTR) of the transcript via seed sequences. 10,11 Many miRNAs are involved in the neoplastic process associated with HNSCC. 1,2,7,[12][13][14][15][16] Our previous studies have shown that there is drastic upregulation of miR-31 in HNSCC.…”

Section: Introductionmentioning

confidence: 99%

Targeting of miR‐31/96/182 to the Numb gene during head and neck oncogenesis

Chou¹,

Chiang³

et al. 2018

Head & Neck

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Section: Introductionmentioning

confidence: 99%

Targeting of miR‐31/96/182 to the Numb gene during head and neck oncogenesis

Chou¹,

Chiang³

et al. 2018

Head & Neck

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“…We therefore hypothesize that HPV infections may promote LR by influencing multiple distinct molecular pathways. However, this possibility needs experimental validation in future studies, as HPV-infected human tissues express viral proteins at barely detectable levels and thus determining the ectopic expression of any given HPV gene remains challenging [55]. In addition, compared with HPV-driven head and neck cancer, epigenetic analysis of HPV-associated OCSCC has demonstrated fewer differences in DNA methylation profiles between HPV-positive and HPV-negative cases [56].…”

Section: Discussionmentioning

confidence: 99%

Molecular and serologic markers of HPV 16 infection are associated with local recurrence in patients with oral cavity squamous cell carcinoma

et al. 2017

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Human papillomavirus (HPV) infections predict mortality in Taiwanese patients with oral cavity squamous cell carcinoma (OCSCC). To address their prognostic significance for local recurrence (LR), in this retrospective cohort study we investigated different serologic and molecular markers of HPV 16 infection in 85 consecutive patients with primary OCSCC who received standard treatment and had their sera stored before treatment. Resected tumor specimens were examined with PCR-based assays for HPV 16 E6/E7 mRNA expression. Sera were tested with suspension arrays for the presence of HPV-specific antibodies using synthetic L1 and E6 peptides as well as a synthetic E7 protein. HPV 16 E6/E7 mRNA, anti-L1, anti-E6, and anti-E7 antibodies tested positive in 12%, 25%, 38%, and 41% of the study patients, respectively. Multivariate analysis identified pathological T3/T4, E6/E7 mRNA, and anti-E7 antibodies as independent risk factors for LR, whereas anti-E6 antibodies were an independent protective factor. In patients with ≥ 3 (high-risk group), 2 (intermediate-risk), and ≤ 1 (low-risk) independent risk factors (predictors), the 5-year LR rates were 75%, 42%, and 4%, respectively. Results were validated in an independent cohort. Together, our preliminary data indicate that HPV 16 infections as well as low and high serum levels of anti-E6 and anti-E7 antibodies, respectively, can serve as biomarkers of LR in patients with OCSCC, whereas the clinical usefulness of anti-HPV 16 antibodies for risk stratification of newly diagnosed cases deserves further scrutiny.

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“…Some estimates suggest that 70-90% of new oropharyngeal cancers have evidence of HPV [10]. Viral regulation of miRNA expression in oral cancer diagnosis including that of Epstein-Barr virus apart from HPV has also been stated in India [11]. Genetic polymorphisms and HPV infection has also been correlated [12].…”

Section: Discussionmentioning

confidence: 99%

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Pal¹,

Raychowdhury²,

Halder³

2016

Otolaryngol (Sunnyvale)

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Objective: The aim is to find out any possible correlation between HPV infection and oral carcinoma along with this metal toxicity. Methods:Ethical clearance for this study was obtained from the Ethics Committee of Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan. Patients attending our hospital were screened for the presence of oral premalignant and malignant lesions. The subjects were administered a standard questionnaire. The buccal swab and hair samples (107 cases and 50 controls) were collected after obtaining informed consent from all the corresponding subjects, and were analysed for detection of HPV 16 DNA and arsenic level analysis, respectively.Results: 22.5% of malignant samples showed the presence of HPV 16 DNA. 80% of cases showed their arsenic count above the safe limit (0.8 µg/g). Conclusion:A considerable percentage of malignant samples showed the presence of HPV16 DNA, indicating that there may be a correlation between HPV infection and oral malignancy in this population. A higher percentage of cases showing an elevated arsenic count states a possible link between arsenic toxicity and the development of this disease. However, a higher population size and statistical analysis are required for a proper conclusion.

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Role of miRNA in cancer diagnosis, prognosis, therapy and regulation of its expression by Epstein–Barr virus and human papillomaviruses: With special reference to oral cancer

Cited by 53 publications

References 83 publications

Targeting of miR‐31/96/182 to the Numb gene during head and neck oncogenesis

Targeting of miR‐31/96/182 to the Numb gene during head and neck oncogenesis

Molecular and serologic markers of HPV 16 infection are associated with local recurrence in patients with oral cavity squamous cell carcinoma

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

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