Role of MiRNA in the Regulation of Blood Group Expression
Romy Kronstein-Wiedemann,
Stephan R. Künzel,
Jessica Thiel
et al.
Abstract:<b><i>Background:</i></b> MicroRNAs (miRNAs) are small, endogenous non-coding RNA molecules that inhibit gene expression through either destabilization of the target mRNA or translational repression. MiRNAs recognize target sites, most commonly found in the 3′-untranslated regions of cognate mRNAs. This review aims to provide a state-of-the-art overview of the role of miRNAs in the regulation of major blood group antigens such as ABH as well as cancer-specific glycans. <b><i>… Show more
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