Role of miRNAs in Normal Endometrium and in Endometrial Disorders: Comprehensive Review

Kolańska, Kamila; Bendifallah, Sofiane; Canlorbe, Geoffroy; Mékinian, A.; Touboul, Cyril; Aractingi, S.; Chabbert-Buffet, Nathalie; Daraı̈, Émile

doi:10.3390/jcm10163457

Cited by 32 publications

(35 citation statements)

References 85 publications

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“…In our own studies, we also showed significant differences in eutopic endometrium of women with endometriosis as compared to controls [ 104 , 105 ]. It is well documented that miRNA expression in the human endometrium is dependent on the menstrual cycle phase and is regulated by sex steroids [ 106 ]. A broad range of different miRNAs involved in the pathogenesis of endometriosis and ectopic pregnancy has been described and they are summarized in Figure 3 [ 35 , 106 , 107 , 108 ].…”

Section: The Role Of Micrornamentioning

confidence: 99%

“…It is well documented that miRNA expression in the human endometrium is dependent on the menstrual cycle phase and is regulated by sex steroids [ 106 ]. A broad range of different miRNAs involved in the pathogenesis of endometriosis and ectopic pregnancy has been described and they are summarized in Figure 3 [ 35 , 106 , 107 , 108 ]. In this part of the review, we focus on miRNAs that may constitute a link between these two diseases.…”

Section: The Role Of Micrornamentioning

confidence: 99%

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Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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Endometriosis is a common inflammatory disease characterized by the presence of endometrial cells outside the uterine cavity. It is estimated that it affects 10% of women of reproductive age. Its pathogenesis covers a wide range of abnormalities, including adhesion, proliferation, and cell signaling disturbances. It is associated with a significant deterioration in quality of life as a result of chronic pelvic pain and may also lead to infertility. One of the most serious complications of endometriosis is an ectopic pregnancy (EP). Currently, the exact mechanism explaining this phenomenon is unknown; therefore, there are no effective methods of prevention. It is assumed that the pathogenesis of EP is influenced by abnormalities in the contraction of the fallopian tube muscles, the mobility of the cilia, and in the fallopian microenvironment. Endometriosis can disrupt function on all three levels and thus contribute to the implantation of the embryo beyond the physiological site. This review takes into account aspects of the molecular mechanisms involved in the pathophysiology of endometriosis and EP, with particular emphasis on the similarities between them.

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Section: The Role Of Micrornamentioning

confidence: 99%

Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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“…Interestingly, the stability of several mRNAs is regulated by estrogens ( Ing, 2005 ). Several microRNAs (miRNA) control gene expression at the posttranscriptional level and can be induced or inhibited by estrogen ( Klinge, 2012 ; Kolanska et al, 2021 ). In addition, E2 canonical signaling pathways mainly mediated by nuclear estrogen receptors can perform as transcription factors to stabilize or destabilize mRNAs via miRNAs modifying gene expression ( Kim et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Site-Specific Regulation of Sulfatase and Aromatase Pathways for Estrogen Production in Endometriosis

Costa

Malvezzi

Dobo

et al. 2022

Front. Mol. Biosci.

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Endometriosis is a highly prevalent gynecological disease characterized by lesions in different sites. Regulation of specific estrogen pathways may favor the formation of distinct microenvironments and the progression of endometriosis. However, no study has simultaneously evaluated the gene and protein regulation of the main estrogen-synthesizing enzymes in endometriosis. Thus, our goals were to study the relationship between gene and protein expression of aromatase (CYP19A1 or ARO), steroid sulfatase (STS), and hydroxysteroid 17-beta dehydrogenase (HSD17B1) in superficial (SUP), ovarian (OMA), and deep infiltrating (DIE) endometriotic lesion sites as well as in the eutopic endometrium of patients with (EE) and without (control) endometriosis in the same and large cohort of patients. The site-specific expression of these enzymes within different cells (glandular and stromal components) was also explored. The study included 108 patients surgically diagnosed with endometriosis who provided biopsies of EE and endometriotic lesions and 16 disease-free patients who collected normal endometrium tissue. Our results showed that CYP19A1 was detected in all endometriosis tissues and was in higher levels than in control. Unique patterns of the STS and HSD17B1 levels showed that they were most closely regulated in all tissues, with manifestation at greater levels in DIE compared to the other endometriotic lesion sites, OMA and SUP. Gene and protein expression of ARO, STS, and HSD17B1 occurred at different rates in endometriotic sites or EE. The distinctive levels of these estrogen-synthesizing enzymes in each endometriotic site support the hypothesis of a tissue microenvironment that can both influence and be influenced by the expression of different estrogenic pathways, locally affecting the availability of estrogen needed for maintenance and progression of endometriotic lesions.

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“…The literature data on the involvement of identified miRNA in embryo implantation and endometrial cancer are resumed in Table 2 [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Ulipristal Acetate Modifies miRNA Expression in Both Superficial and Basal Layers of the Human Endometrium

Kolańska

Sbeih

Canlorbe

et al. 2021

JCM

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(1) Background: Ulipristal acetate (UPA) is a selective progesterone receptor modulator (SPRM) widely used for emergency contraception and mid- to long-term leiomyoma treatment. The aim of this study was to identify modifications of miRNA expression in superficial and basal layers of the human endometrium at the end of the UPA treatment for at least 3 months. (2) Methods: Microarray miRNA analysis of formalin-fixed, paraffin-embedded hysterectomy tissue samples was conducted, followed by an Ingenuity Pathway Analysis. Samples were divided into three groups: women having had 3 months of UPA treatment (n = 7); and two control groups of UPA-naïve women in the proliferative (n = 8) or secretory (n = 6) phase. (3) Results: The UPA modified the expression of 59 miRNAs involved in the processes of cell cycle, carcinogenesis, and inflammation. Their expression profiles were different in the basal and superficial layers. Most of the processes influenced by the UPA in the basal layer were connected to the cell cycle and immune regulation. (4) Conclusion: Specific changes were observed in both layers of the endometrium in the UPA group. However, the miRNA expression in the basal layer was not consistent with that in the superficial layer. Other large studies analysing the long-term impact of SPRM on endometrial miRNA expression are necessary.

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Role of miRNAs in Normal Endometrium and in Endometrial Disorders: Comprehensive Review

Cited by 32 publications

References 85 publications

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Site-Specific Regulation of Sulfatase and Aromatase Pathways for Estrogen Production in Endometriosis

Ulipristal Acetate Modifies miRNA Expression in Both Superficial and Basal Layers of the Human Endometrium

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