Role of mitophagy in the neurodegenerative diseases and its pharmacological advances: A review

Wang, Qixia; Xue, Haoyuan; Yue, Yun-Di; Hao, Shuai; Huang, Shuhong; Zhang, Zhaoqiang

doi:10.3389/fnmol.2022.1014251

Cited by 10 publications

(6 citation statements)

References 117 publications

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“…It usually occurs in mitochondria that are defective after injury or stress. Mitophagy promotes the renewal of mitochondria and prevents the accumulation of dysfunctional mitochondria, which may lead to cellular degeneration ( Wang et al, 2022 ). Mitophagy is activated in mammalian cells by PINK1/Parkin-mediated mitophagy ( Iorio et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…PINK1 affects the health of mitochondrial ( Nguyen et al, 2016 ). PINK1 activates Parkin via phosphorylation, which is an E3 ubiquitin ligase located in the cytoplasm ( Bingol and Sheng, 2016 ; Wang et al, 2022 ). YBX1, a positive regulator of mitophagy, by enhancing PINK1/PRKN-mediating mitophagy in brown adipocyte ( Wu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

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Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos

Jiang,

Lee,

Heo

et al. 2023

Front. Cell Dev. Biol.

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Y-box binding protein 1 (YBX1) plays important roles in RNA stabilization, translation, transcriptional regulation, and mitophagy. However, its effects on porcine preimplantation embryos remain unclear. In this study, we knocked down YBX1 in the one-cell (1C) stage embryo via small interfering RNA microinjection to determine its function in porcine embryo development. The mRNA level of YBX1 was found to be highly expressed at the four-cell (4C) stage in porcine embryos compared with one-cell (1C) and two-cell (2C) stages. The number of blastocysts was reduced following YBX1 knockdown. Notably, YBX1 knockdown decreased the phosphatase and tensin homolog-induced kinase 1 (PINK1) and parkin RBR E3 ubiquitin protein ligase (PRKN) mRNA levels. YBX1 knockdown also decreased PINK1, active mitochondria, and sirtuin 1 levels, indicating reduced mitophagy and mitochondrial biogenesis. Furthermore, YBX1 knockdown increased the levels of glucose-regulated protein 78 (GRP78) and calnexin, leading to endoplasmic reticulum (ER) stress. Additionally, YBX1 knockdown increased autophagy and apoptosis. In conclusion, knockdown of YBX1 decreases mitochondrial function, while increasing ER stress and autophagy during embryonic development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos

Jiang,

Lee,

Heo

et al. 2023

Front. Cell Dev. Biol.

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“…Similarly, Saita et al found that depletion of Drp1, a protein involved in mitochondrial fission, led to decreased levels of MFNs and OPA1 [108]. The other studies highlight the significant linkage between parkin-dependent mitophagy and neurodegenerative diseases, including Alzheimer's and Parkinson's diseases [109][110][111].…”

Section: Protein Machinery In Mitochondrial Fusionmentioning

confidence: 93%

Mitochondrial Dynamics in Neurodegenerative Diseases: Unraveling the Role of Fusion and Fission Processes

Grel,

Woznica,

Ratajczak

et al. 2023

IJMS

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Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the progressive degeneration and death of neurons, leading to a range of neurological symptoms. Despite the heterogeneity of these conditions, a common denominator is the implication of mitochondrial dysfunction in their pathogenesis. Mitochondria play a crucial role in creating biomolecules, providing energy through adenosine triphosphate (ATP) generated by oxidative phosphorylation (OXPHOS), and producing reactive oxygen species (ROS). When they’re not functioning correctly, becoming fragmented and losing their membrane potential, they contribute to these diseases. In this review, we explore how mitochondria fuse and undergo fission, especially in the context of NDs. We discuss the genetic and protein mutations linked to these diseases and how they impact mitochondrial dynamics. We also look at the key regulatory proteins in fusion (MFN1, MFN2, and OPA1) and fission (DRP1 and FIS1), including their post-translational modifications. Furthermore, we highlight potential drugs that can influence mitochondrial dynamics. By unpacking these complex processes, we aim to direct research towards treatments that can improve life quality for people with these challenging conditions.

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“…A significant topic implicated in the pathogenesis of NDDs is defective mitophagy [ 164 , 165 , 166 , 167 , 168 ]. It is defined as the selective autophagy or turnover of mitochondria.…”

Section: Biochemical Pathways Involving Protein Homeostasis Autophagy...mentioning

confidence: 99%

Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View

Sanghai,

Tranmer

2023

Cells

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Neurodegenerative diseases (NDDs) like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex aetiologies. Understanding the common biochemical molecular pathologies among NDDs gives an opportunity to decipher the overlapping and numerous cross-talk mechanisms of neurodegeneration. Numerous interrelated pathways lead to the progression of neurodegeneration. We present evidence from the past pieces of literature for the most usual global convergent hallmarks like ageing, oxidative stress, excitotoxicity-induced calcium butterfly effect, defective proteostasis including chaperones, autophagy, mitophagy, and proteosome networks, and neuroinflammation. Herein, we applied a holistic approach to identify and represent the shared mechanism across NDDs. Further, we believe that this approach could be helpful in identifying key modulators across NDDs, with a particular focus on AD, PD, and ALS. Moreover, these concepts could be applied to the development and diagnosis of novel strategies for diverse NDDs.

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Role of mitophagy in the neurodegenerative diseases and its pharmacological advances: A review

Cited by 10 publications

References 117 publications

Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos

Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos

Mitochondrial Dynamics in Neurodegenerative Diseases: Unraveling the Role of Fusion and Fission Processes

Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View

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