Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Fu, Zhiling; Zhang, Jin; Zhang, Yan

doi:10.1155/2022/2249749

Cited by 23 publications

(15 citation statements)

References 196 publications

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“…However, in 2007, scholars discovered that H 2 can exert antioxidant properties and prevent ischemia-reperfusion injury in a rat model (Ohsawa et al, 2007). Since then, a large number of studies have explored the therapeutic and preventive effects of H 2 in different diseases, including metabolic diseases, neurological diseases, cancer, and many aging-related diseases (Liu et al, 2020;Liu et al, 2021;Fu et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial

Liu

Jiang²,

Xie³

et al. 2022

Front. Pharmacol.

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Objective: To explore the effect of a low-dose hydrogen–oxygen (H2-O2) mixture inhalation in midlife/older adults with hypertension.Methods: This randomized, placebo-controlled trial included 60 participants with hypertension aged 50–70 years who were randomly divided into Air group (inhaled placebo air) or H2-O2 group [inhaled H2-O2 mixture (66% H2/33% O2)]. Participants in both groups were treated 4 h per day for 2 weeks. Four-limb blood pressure and 24-h ambulatory blood pressure were monitored before and after the intervention, and levels of plasma hormones related to hypertension were determined.Results: A total of 56 patients completed the study (27 in the Air group and 29 in the H2-O2 group). The right and left arm systolic blood pressure (SBP) were significantly decreased in H2-O2 group compared with the baseline levels (151.9 ± 12.7 mmHg to 147.1 ± 12.0 mmHg, and 150.7 ± 13.3 mmHg to 145.7 ± 13.0 mmHg, respectively; all p < 0.05). Meanwhile, the H2-O2 intervention significantly decreased diastolic nighttime ambulatory blood pressure by 2.7 ± 6.5 mmHg (p < 0.05). All blood pressures were unaffected in placebo group (all p > 0.05). When stratified by age (aged 50–59 years versus aged 60–70 years), participants in the older H2-O2 group showed a larger reduction in right arm SBP compared with that in the younger group (p < 0.05). In addition, the angiotensin II, aldosterone, and cortisol levels as well as the aldosterone-to-renin ratio in plasma were significantly lower in H2-O2 group compared with baseline (p < 0.05). No significant differences were observed in the Air group before and after the intervention.Conclusion: Inhalation of a low-dose H2-O2 mixture exerts a favorable effect on blood pressure, and reduces the plasma levels of hormones associated with hypertension on renin-angiotensin-aldosterone system and stress in midlife/older adults with hypertension.

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Section: Discussionmentioning

confidence: 99%

The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial

Liu

Jiang²,

Xie³

et al. 2022

Front. Pharmacol.

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“…Oxidative damage to proteins is divided in two categories, including the reversible and irreversible protein modifications ( Caliri et al, 2021 ; Fu et al, 2022 ). Protein carbonylation is an irreversible protein modification, resulting from oxidative damage, that often leads to loss of protein function ( Matsuo et al, 2021 ).…”

Section: Oxidative Stressmentioning

confidence: 99%

Role of oxidative stress in the relationship between periodontitis and systemic diseases

et al. 2023

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Periodontitis is a common inflammatory disease. It is characterized by destruction of the supporting structures of the teeth and could lead to tooth loss and systemic inflammation. Bacteria in inflamed gingival tissue and virulence factors are capable of entering the bloodstream to induce systemic inflammatory response, thus influencing the pathological process of many diseases, such as cardiovascular diseases, diabetes, chronic kidney disease, as well as liver injury. An increasing body of evidence show the complex interplay between oxidative stress and inflammation in disease pathogenesis. When periodontitis occurs, increased reactive oxygen species accumulation leads to oxidative stress. Oxidative stress contributes to major cellular components damage, including DNA, proteins, and lipids. In this article, the focus will be on oxidative stress in periodontal disease, the relationship between periodontitis and systemic inflammation, and the impact of periodontal therapy on oxidative stress parameters.

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“…Clinical studies on hydrogen have demonstrated its potential application for cognitive impairment [ 9 ], metabolic syndrome [ 10 ], stroke [ 11 ], COVID-19 [ 12 ], and in exercise medicine [ 7 ]. The clinical and molecular effects of hydrogen gas have been extensively reviewed [ 13 , 14 ].…”

Section: Physicochemical Properties and Biological Effects Of Molecul...mentioning

confidence: 99%

Electrolyzed–Reduced Water: Review I. Molecular Hydrogen Is the Exclusive Agent Responsible for the Therapeutic Effects

LeBaron

Sharpe²,

Ohno

2022

IJMS

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Numerous benefits have been attributed to alkaline-electrolyzed–reduced water (ERW). Sometimes these claims are associated with easily debunked concepts. The observed benefits have been conjectured to be due to the intrinsic properties of ERW (e.g., negative oxidation–reduction potential (ORP), alkaline pH, H2 gas), as well enigmatic characteristics (e.g., altered water structure, microclusters, free electrons, active hydrogen, mineral hydrides). The associated pseudoscientific marketing has contributed to the reluctance of mainstream science to accept ERW as having biological effects. Finally, through many in vitro and in vivo studies, each one of these propositions was examined and refuted one-by-one until it was conclusively demonstrated that H2 was the exclusive agent responsible for both the negative ORP and the observed therapeutic effects of ERW. This article briefly apprised the history of ERW and comprehensively reviewed the sequential research demonstrating the importance of H2. We illustrated that the effects of ERW could be readily explained by the known biological effects of H2 and by utilizing conventional chemistry without requiring any metaphysical conjecture (e.g., microclustering, free electrons, etc.) or reliance on implausible notions (e.g., alkaline water neutralizes acidic waste). The H2 concentration of ERW should be measured to ensure it is comparable to those used in clinical studies.

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Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Cited by 23 publications

References 196 publications

The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial

The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial

Role of oxidative stress in the relationship between periodontitis and systemic diseases

Electrolyzed–Reduced Water: Review I. Molecular Hydrogen Is the Exclusive Agent Responsible for the Therapeutic Effects

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