Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Caobelli, Federico; Evangelista, Laura; Quartuccio, Natale; Familiari, Demetrio; Altini, Corinna; Castello, Angelo; Cucinotta, Mariapaola; Dato, Rossella Di; Ferrari, Cristina; Kokomani, Aurora; Laghai, Iashar; Laudicella, Riccardo; Migliari, Silvia; Orsini, Federica; Pignata, Salvatore Antonio; Popescu, Cristina; Puta, Erinda; Ricci, Martina; Seghezzi, Silvia; Sindoni, Alessandro; Sollini, Martina; Sturiale, Letterio; Svyridenka, Anna; Vergura, Vittoria; Alongi, Pierpaolo

doi:10.4329/wjr.v8.i10.829

Cited by 19 publications

(18 citation statements)

References 64 publications

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“…A number of novel imaging technologies are emerging that complement or may even replace endoscopy as the gold standard for clinical diagnosis, as recently reviewed in detail [ 10 , 11 ]. Chromoendography involves the application of dyes onto the mucosa, improving endoscopic characterization of lesions and neoplasia, and has the potential to correlate with histological damage, although the latter remains controversial [ 12 ].…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

“…Gadolinium-contrasted MRI has recently been shown to reliably predict severe fibrosis in CD and, interestingly, also revealed that areas of fibrosis often coexist with inflammation within the same intestinal segment [ 20 ]. A recent comprehensive review of the use of PET/SPECT for IBD diagnosis, prognosis, and follow-up indicated that 2-deoxy-2-[ 18 F]fluoro- d -glucose ( 18 F-FDG) coupled with CT has the highest accuracy for detecting inflammation in IBD [ 11 ]. 18 F-FDG is a radiolabeled glucose analogue that detects tissue glucose metabolism and has been the tracer of choice for PET studies for decades; however, radiolabeled leukocytes are also typically used to assess GI inflammation.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

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Advances in Imaging Specific Mediators of Inflammatory Bowel Disease

Dmochowska

Wardill

Hughes

2018

IJMS

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Inflammatory bowel disease (IBD) is characterized by chronic remitting and relapsing inflammation of the lower gastrointestinal tract. The etiology underlying IBD remains unknown, but it is thought to involve a hypersensitive immune response to environmental antigens, including the microbiota. Diagnosis and monitoring of IBD is heavily reliant on endoscopy, which is invasive and does not provide information regarding specific mediators. This review describes recent developments in imaging of IBD with a focus on positron emission tomography (PET) and single-photon emission computed tomography (SPECT) of inflammatory mediators, and how these developments may be applied to the microbiota.

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Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Advances in Imaging Specific Mediators of Inflammatory Bowel Disease

Dmochowska

Wardill

Hughes

2018

IJMS

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“…Clinical studies support the use of PET, SPECT, and MRI for detecting inflammation in the gastrointestinal tract, satisfying the criteria for reduced invasiveness and real-time information (4,5). However, current clinical PET, SPECT, and MRI approaches in IBD are restricted to using radiolabeled autologous leukocytes and 18 F-FDG in PET and SPECT and using gadolinium contrast in MRI, none of which provides information on specific mediators.…”

mentioning

confidence: 99%

Immuno-PET of Innate Immune Markers CD11b and IL-1β Detects Inflammation in Murine Colitis

et al. 2018

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Inflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory disease of the gastrointestinal tract. The diagnosis and monitoring of IBD are reliant on endoscopy, which is invasive and does not provide information on specific mediators. Symptom flare in IBD is associated with increased activation of innate immune pathways. Immuno-PET approaches have previously demonstrated the ability to detect colitis; however, a direct comparison of antibodies targeted to innate immune mediators and cells has not been done. We aimed to compare immuno-PET of antibodies to IL-1β and CD11b against standard 18 F-FDG and MRI approaches to detect colonic inflammation. Methods: Colonic concentrations of IL-1β and myeloperoxidase were determined by ELISA, and colonic infiltration by CD11b-positive CD3-negative innate immune cells was determined by flow cytometry and compared between healthy and dextran sodium sulphate-treated colitic mice. PET of 89 Zr-lα-IL-1β, 89 Zr-α-CD11b, and 18 F-FDG was compared by volume-of-interest analysis and with MRI by region-of-interest analysis. Imaging results were confirmed by ex vivo biodistribution analysis. Results: Colonic inflammation was associated with impaired colonic epithelial barrier permeability, increased colonic IL-1β and myeloperoxidase concentrations, and increased CD11b-positive CD3-negative innate immune cell infiltration into the colon. 89 Zr-α-IL-1β and 89 Zr-α-CD11b immuno-PET detected colonic inflammation, as did 18 F-FDG, and all PET tracers were more sensitive than MRI. Although 18 F-FDG volumes of interest correlated with colitis severity and a strong trend was observed with 89 Zr-α-IL-1β, no correlation was observed for 89 Zr-α-CD11b or MRI. 89 Zr-α-IL-1β was distributed mainly to the gastrointestinal tract, whereas 89 Zr-α-CD11b was distributed to more tissue types. Conclusion: Immuno-PET using antibodies directed to innate immune markers detected colonic inflammation, with 89 Zr-α-IL-1β providing a more tissue-specific signal than 89 Zr-α-CD11b. Development of these technologies for human subjects will potentially provide a less invasive approach than endoscopy for diagnosing and monitoring IBD. Detects Inflammation inβ Immuno-PET of Innate Immune Markers CD11b and IL-1 http://jnm.snmjournals.org/content/60/6/858 This article and updated information are available at: http://jnm.snmjournals.org/site/subscriptions/online.xhtml Information about subscriptions to JNM can be found at: http://jnm.snmjournals.org/site/misc/permission.xhtml

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“…However, prospective multicenter studies on larger patient samples are needed for validation. 72 Wang et al 73 reported that ultrasonography with clinically translatable dual-targeted (P-and E-selectin) contrast microbubbles specifically enables detection and quantification of inflammation in a murine acute colitis model, leveraging the natural pathway of leukocyte recruitment in inflammatory tissue. They also demonstrated that ultrasonography imaging with contrast shows a correlation well with fluorodeoxyglucose uptake on PET/CT imaging.…”

Section: Evaluation Of Disease Activity and Prediction Of Therapeuticmentioning

confidence: 99%

Endoscopic molecular imaging in inflammatory bowel disease

Ham

Myung

2021

Intest Res

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technological and scientific developments of GI endoscopy have created new imaging devices, such as virtual chromoendoscopy techniques, chromoendoscopy, narrow-band imaging, autofluorescence imaging, Raman spectroscopy and confocal laser endomicroscopy (CLE), all of which can help to improve the characterization and detection of early neoplasms. 5 Although these advances, endoscopy is diagnostically limited because it discriminates based on morphological changes. Recently, molecular mechanisms at the cellular level have been revealed for many physiological and pathological conditions such as cancer and inflammation. Therefore, to significantly increase the early detection rate of endoscopic examination, a method of searching for changes at the cellular level, rather than for morphological changes, has been devised. Molecular imaging is a technique for imaging the processes occurring in a living body at the molecular level, combining advanced imaging technology with molecular cell biology. Molecular imaging has evolved, and it is now able to reveal the

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Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Cited by 19 publications

References 64 publications

Advances in Imaging Specific Mediators of Inflammatory Bowel Disease

Advances in Imaging Specific Mediators of Inflammatory Bowel Disease

Immuno-PET of Innate Immune Markers CD11b and IL-1β Detects Inflammation in Murine Colitis

Endoscopic molecular imaging in inflammatory bowel disease

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