Role of mouse polyomavirus late region in the control of viral DNA replication: A review

Iacoangeli, Anna; Melucci-Vigo, Gianna; Risuleo, Gianfranco; Santi, Elisabetta

doi:10.1016/0300-9084(96)88196-x

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…Rearrangements in the SV40 NCCR affect viral transcription and replication, as well as oncogenic properties of the virus [45,46]. The Mouse polyomavirus (Mus musculus polyomavirus 1; MPyV) NCCR encompasses the ori consisting of an AT-tract and a GC-rich (LT binding motifs) inverted repeat, and the transcription regulatory domains A (or α) and B (or β), C and D [47][48][49][50]. Alterations in the MPyV NCCR have an effect on viral replication in cell culture and in the host, the host range, and in vitro transformation [51][52][53][54][55].…”

Section: Virus Original Source Associated Disease Referencementioning

confidence: 99%

Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses

Moens

Prezioso

Pietropaolo

2020

Viruses

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The genomes of polyomaviruses are characterized by their tripartite organization with an early region, a late region and a noncoding control region (NCCR). The early region encodes proteins involved in replication and transcription of the viral genome, while expression of the late region generates the capsid proteins. Transcription regulatory sequences for expression of the early and late genes, as well as the origin of replication are encompassed in the NCCR. Cell tropism of polyomaviruses not only depends on the appropriate receptors on the host cell, but cell-specific expression of the viral genes is also governed by the NCCR. Thus far, 15 polyomaviruses have been isolated from humans, though it remains to be established whether all of them are genuine human polyomaviruses (HPyVs). The sequences of the NCCR of these HPyVs show high genetic variability and have been best studied in the human polyomaviruses BK and JC. Rearranged NCCRs in BKPyV and JCPyV, the first HPyVs to be discovered approximately 30 years ago, have been associated with the pathogenic properties of these viruses in nephropathy and progressive multifocal leukoencephalopathy, respectively. Since 2007, thirteen novel PyVs have been isolated from humans: KIPyV, WUPyV, MCPyV, HPyV6, HPyV7, TSPyV, HPyV9, HPyV10, STLPyV, HPyV12, NJPyV, LIPyV and QPyV. This review describes all NCCR variants of the new HPyVs that have been reported in the literature and discusses the possible consequences of NCCR diversity in terms of promoter strength, putative transcription factor binding sites and possible association with diseases.

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Section: Virus Original Source Associated Disease Referencementioning

confidence: 99%

Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses

Moens

Prezioso

Pietropaolo

2020

Viruses

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“…Portions of VP1, though, appear to be required for efficient Py transcription and replication since they associate with the nuclear matrix-associated transcription factor YY1 and, along with other as yet identified proteins, may be important for bringing the initial transcription factors required for early transcription to the Py enhancer (252). There are a number of studies indicating a role for the late region, both the sequences and the proteins expressed, in Py transcription and replication, although the connection to MT and the other early proteins is still be elucidated (123,156,199,226).…”

Section: Regulation Of Transcriptionmentioning

confidence: 99%

Natural Biology of Polyomavirus Middle T Antigen

Gottlieb

Villarreal

2001

Microbiol Mol Biol Rev

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“It has been commented by someone that ‘polyoma’ is an adjective composed of a prefix and suffix, with no root between—a meatless linguistic sandwich” (C. J. Dawe). The very name “polyomavirus” is a vague mantel: a name given before our understanding of these viral agents was clear but implying a clear tumor life-style, as noted by the late C. J. Dawe. However, polyomavirus are not by nature tumor-inducing agents. Since it is the purpose of this review to consider the natural function of middle T antigen (MT), encoded by one of the seemingly crucial transforming genes of polyomavirus, we will reconsider and redefine the virus and its MT gene in the context of its natural biology and function. This review was motivated by our recent in vivo analysis of MT function. Using intranasal inoculation of adult SCID mice, we have shown that polyomavirus can replicate with an MT lacking all functions associated with transformation to similar levels to wild-type virus. These observations, along with an almost indistinguishable replication of all MT mutants with respect to wild-type viruses in adult competent mice, illustrate that MT can have a play subtle role in acute replication and persistence. The most notable effect of MT mutants was in infections of newborns, indicating that polyomavirus may be highly adapted to replication in newborn lungs. It is from this context that our current understanding of this well-studied virus and gene is presented

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Infection & Neoplastic Growth 101

Bertout¹,

Thomas-Tikhonenko²

2006

The Link Between Inflammation and Cancer

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Role of mouse polyomavirus late region in the control of viral DNA replication: A review

Cited by 6 publications

References 37 publications

Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses

Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses

Natural Biology of Polyomavirus Middle T Antigen

Infection & Neoplastic Growth 101

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