Role of MRI in Primary Brain Tumor Evaluation

Leung, Denise; Han, Xiaosi; Mikkelsen, Tom; Nabors, Louis B.

doi:10.6004/jnccn.2014.0156

Cited by 34 publications

(33 citation statements)

References 55 publications

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“…MRI is used extensively to characterize tumors, due to its high soft-tissue contrast and superior image resolution. Beyond T1- and T2-weighted measurements of changes in tumor volume (Jost et al , 2007; Leung et al , 2014; Ellingson et al , 2015), a number of different MR-based methods have been examined for evaluating treatment response, including diffusion imaging (Farjam et al , 2014; Moffat et al , 2006; Tsien et al , 2014), perfusion imaging (Hakyemez et al , 2005; Law et al , 2008), and MR spectroscopy (Horska and Barker, 2010; Kumar et al , 2015). Although these techniques have shown promise for detecting and characterizing recurrent tumors after radiation treatment, none represent current standard of care for assessing treatment response.…”

Section: Introductionmentioning

confidence: 99%

A longitudinal magnetic resonance elastography study of murine brain tumors following radiation therapy

et al. 2016

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An accurate and noninvasive method for assessing treatment response following radiotherapy is needed for both treatment monitoring and planning. Measurement of solid tumor volume alone is not sufficient for reliable early detection of therapeutic response, since changes in physiological and/or biomechanical properties can precede tumor volume change following therapy. In this study, we use magnetic resonance elastography (MRE) to evaluate the treatment effect after radiotherapy in a murine brain tumor model. Shear modulus was calculated and compared between the delineated tumor region of interest (ROI) and its contralateral, mirrored counterpart. We also compared the shear modulus from both the irradiated and non-irradiated tumor and mirror ROIs longitudinally, sampling four time points spanning 9 to 19 days post tumor implant. Results showed that the tumor ROI had a lower shear modulus than that of the mirror ROI, independent of radiation. The shear modulus of the tumor ROI decreased over time for both the treated and untreated groups. By contrast, the shear modulus of the mirror ROI appeared to be relatively constant for the treated group, while an increasing trend was observed for the untreated group. The results provide insights into the tumor properties after radiation treatment and demonstrate the potential of using the mechanical properties of the tumor as a biomarker. In future studies, more closely spaced time points will be employed for detailed analysis of the radiation effect.

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Section: Introductionmentioning

confidence: 99%

A longitudinal magnetic resonance elastography study of murine brain tumors following radiation therapy

et al. 2016

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“…14 For these WHO-classified grade-II diffuse gliomas without disruption of the blood-brain barrier and contrast enhancement, the FLAIR sequence is recommended by the American National Comprehensive Cancer Network because it can provide the best delineation and volumetric measurements of the tumor in region of interest (ROI) placement or intraoperative navigation. 15,16 Also, T 2 FLAIR images provide a measure of free water and eliminate the signal from cerebrospinal fluid, which may help improve the diagnostic precision of lesions in the cortical/subcortical areas that oligodendrogliomas are frequently located in. 8,17 Therefore, T 2 FLAIR images, as a scanning sequence used routinely in institution, were selected to analyze texture features in the present study.…”

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confidence: 99%

MR textural analysis on T₂ FLAIR images for the prediction of true oligodendroglioma by the 2016 WHO genetic classification

Rui

Ren

Wang

et al. 2017

Magnetic Resonance Imaging

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“…MRI is the recommended modality for evaluation of the brain tissues due to its superior resolution compared to CT scanning [16]. Fusion of diagnostic MRIs to RT planning CTs is a widely used method for accurate target delineation in various cancers, and it is most emphasized for brain tumors [5][6][7].…”

Section: Discussionmentioning

confidence: 99%

Interim Tumor Progression and Volumetric Changes of Surgical Cavities during the Surgery-to-Radiotherapy Interval in Anaplastic Gliomas: Implications for Additional Pre-radiotherapy Magnetic Resonance Imaging

et al. 2020

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PurposeThis study was designed to investigate the incidence of interim disease progression (IPD) and volumetric changes of the surgical cavity (SC) during the surgery-to-radiotherapy interval (SRI), and eventually assess the value of magnetic resonance imaging (MRI) at the time of radiotherapy (RT) planning in newly diagnosed anaplastic gliomas.Materials and MethodsAmong 195 anaplastic glioma patients who underwent RT, 121 were evaluable with two separate MRIs during SRI. The presence of IPD was determined using the updated Response Assessment in Neuro-Oncology size criteria. In 84 patients who underwent surgical resection, each SC was contoured by a radiation oncologist and the volumetric changes of the SCs were calculated between the two separate MRIs. Daily rate of change in the SC volume was calculated assuming an exponential and linear change.ResultsFive of 121 patients (4.13%) demonstrated IPD during SRI, and the incidence was significantly higher in patients undergoing biopsy (vs. surgical resection, 12.9% vs. 1.1%, p=0.015) and in patients with remnant contrast-enhancing tumor after surgery (15.8 vs. 2.0%, p=0.027). The mean daily rate of absolute change in SC was 1.06% (95% confidence interval [CI], 0.89 to 1.23) and 0.89% (95% CI, 0.77 to 1.02) according to the exponential and linear model, respectively. The expected mean volumetric change at 2 weeks were 16.64% (95% CI, 13.77 to 19.52) and 12.51% (95% CI, 10.77 to 14.26), respectively.ConclusionIPD during the SRI is rare in surgically resected anaplastic gliomas. However, pre-RT MRI is essential for accurate RT-target delineation and disease evaluation for patients initiating RT beyond postoperative 2 weeks and undergoing biopsy, respectively.

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Role of MRI in Primary Brain Tumor Evaluation

Cited by 34 publications

References 55 publications

A longitudinal magnetic resonance elastography study of murine brain tumors following radiation therapy

A longitudinal magnetic resonance elastography study of murine brain tumors following radiation therapy

MR textural analysis on T₂ FLAIR images for the prediction of true oligodendroglioma by the 2016 WHO genetic classification

Interim Tumor Progression and Volumetric Changes of Surgical Cavities during the Surgery-to-Radiotherapy Interval in Anaplastic Gliomas: Implications for Additional Pre-radiotherapy Magnetic Resonance Imaging

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Role of MRI in Primary Brain Tumor Evaluation

Cited by 34 publications

References 55 publications

A longitudinal magnetic resonance elastography study of murine brain tumors following radiation therapy

A longitudinal magnetic resonance elastography study of murine brain tumors following radiation therapy

MR textural analysis on T2 FLAIR images for the prediction of true oligodendroglioma by the 2016 WHO genetic classification

Interim Tumor Progression and Volumetric Changes of Surgical Cavities during the Surgery-to-Radiotherapy Interval in Anaplastic Gliomas: Implications for Additional Pre-radiotherapy Magnetic Resonance Imaging

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MR textural analysis on T₂ FLAIR images for the prediction of true oligodendroglioma by the 2016 WHO genetic classification