Role of MRI perfusion in improving the treatment of brain tumors

Fussell, David; Young, Robert J.

doi:10.2217/iim.13.50

Cited by 12 publications

(11 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We thus may underestimate the strength of the evidence. Reviews with such partial responses included: "was the search strategy comprehensive", (DTI-mTBI, n 5 [45][46][47][48]52,53,55,57,63,64,66 ), "are all of the results presented with confidence intervals", (DTI-mTBI n 5 1; 34 DSCglioma n 5 4 50-52,65 ), "does it state the study design of all included articles" (DTI-mTBI, n 5 3; 25,39,44 DSC-glioma, n 5 3 62,64 ) and "does it specify the number of subjects for all included studies" (DTI-mTBI, n 5 11; 8,25,27,28,31,34,37,38,40,42,44 DSC-glioma, n 5 8 47,50,51,57,60,61,63,64 ).…”

Section: Discussionmentioning

confidence: 99%

“…Regarding critical appraisal worksheet grades for DTI-mTBI detection reviews, 1 review achieved Grade A, 29 8 reviews achieved Grade B 8,24,25,36,39,41,42,44 and 14 reviews achieved Grade C. 6,[26][27][28][30][31][32][33][34][35]37,38,40,43 Of the reviews of DTI-mTBI outcome prediction, three reviews achieved Grade B 25,39,41 and the remaining reviews were Grade C. 6,[26][27][28][30][31][32]37,40 Of the reviews of DSC-glioma detection, 1 review achieved Grade A, 7 1 review achieved Grade B 62 and 24 reviews achieved Grade C. 9,12,[45][46][47][48][49][50][51][52][53][54]…”

Section: Classification and Grading Of Individual Review's Overall Qumentioning

confidence: 99%

See 1 more Smart Citation

Advanced neuroimaging in the clinic: critical appraisal of the evidence base

Fink

Mogil

Lipton

2016

BJR

View full text Add to dashboard Cite

The shortage of high-quality systematic reviews in the field of radiology limits evidence-based integration of imaging methods into clinical practice and may perpetuate misconceptions regarding the efficacy and appropriateness of imaging techniques for specific applications. Diffusion tensor imaging for patients with mild traumatic brain injury (DTI-mTBI) and dynamic susceptibility contrast MRI for patients with glioma (DSC-glioma) are applications of quantitative neuroimaging, which similarly detect manifestations of disease where conventional neuroimaging techniques cannot. We performed a critical appraisal of reviews, based on the current evidence-based medicine methodology, addressing the ability of DTImTBI and DSC-glioma to (a) detect brain abnormalities and/or (b) predict clinical outcomes. 23 reviews of DTI-mTBI and 26 reviews of DSC-glioma met criteria for inclusion. All reviews addressed detection of brain abnormalities, whereas 12 DTI-mTBI reviews and 22 DSC-glioma reviews addressed prediction of a clinical outcome. All reviews were assessed using a critical appraisal worksheet consisting of 19 yes/no questions. Reviews were graded according to the total number of positive responses and the 2011 Oxford Centre for evidence-based medicine levels of evidence criteria. Reviews addressing DTI-mTBI detection had moderate quality, while those addressing DSC-glioma were of low quality. Reviews addressing prediction of outcomes for both applications were of low quality. Five DTI-mTBI reviews, but only one review of DSC-glioma met criteria for classification as a meta-analysis/systematic/quantitative review. INTRODUCTIONEvidence-based medicine (EBM) principles have been widely adopted as the gold standard and even the expected basis for everyday clinical practice. However, adoption of EBM principles in radiology has greatly lagged behind other clinical specialities. 1,2 In fact, the clinical utility of less than one-third of diagnostic imaging procedures is supported by sufficient evidence; as opposed to merely experience and opinion. 2,3 According to EBM standards, systematic reviews constitute the highest level of evidence because they consolidate the evidence of multiple studies rather than relying on the results of one individual study, with its inherent biases, alone. 2,4 Optimal reviews, which adopt EBM practices, provide a comprehensive overview of primary investigations of a specific topic through systematically and comprehensively searching and critically appraising the literature. While many narrative and educational

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Classification and Grading Of Individual Review's Overall Qumentioning

confidence: 99%

Advanced neuroimaging in the clinic: critical appraisal of the evidence base

Fink

Mogil

Lipton

2016

BJR

View full text Add to dashboard Cite

show abstract

“…7 It tracks the first pass of a bolus of gadolinium-based contrast through brain tissue. 1 Passage of contrast agent through the tissue vasculature typically causes a transient decrease in brain signal intensity (SI). This signal loss is used to assess the concentration of contrast agent as a function of time, in each voxel of the image.…”

Section: Dsc Mrimentioning

confidence: 99%

“…Magnetic resonance imaging (MRI) is the technique of choice for evaluation of cerebral tumours. 1 Conventional T1- and T2-weighted MRIs are highly sensitive for detection of cerebral tumours; and can indicate the presence of oedema, mass effect, haemorrhage and tissue necrosis 2 ; however, conventional MRI is sometimes unable to differentiate between certain contrast-enhancing lesions, making diagnosis challenging.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 In particular, perfusion MRI techniques such as dynamic susceptibility-weighted contrast-enhanced (DSC) imaging are considered useful for viewing various pathologies that disrupt tissue perfusion. 1 DSC MRI has been applied to diagnosis and grading of cerebral tumours, distinguishing tumour recurrence from radiation necrosis, and evaluating the response to therapy through deriving two clinically useful parameters: Percentage of signal intensity recovery (PSR) and relative cerebral blood volume (rCBV) 10,12 ; however, despite its potential clinical utility, DSC MRI remains largely a research tool.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Accuracy of percentage of signal intensity recovery and relative cerebral blood volume derived from dynamic susceptibility-weighted, contrast-enhanced MRI in the preoperative diagnosis of cerebral tumours

2015

View full text Add to dashboard Cite

Conventional magnetic resonance imaging (MRI) is the technique of choice for diagnosis of cerebral tumours, and has become an increasingly powerful tool for their evaluation; however, the diagnosis of common contrast-enhancing lesions can be challenging, as it is sometimes impossible to differentiate them using conventional imaging. Histopathological analysis of biopsy specimens is the gold standard for diagnosis; however, there are significant risks associated with the invasive procedure and definitive diagnosis is not always achieved. Early accurate diagnosis is important, as management differs accordingly. Advanced MRI techniques have increasing utility for aiding diagnosis in a variety of clinical scenarios. Dynamic susceptibility-weighted contrast-enhanced (DSC) MRI is a perfusion imaging technique and a potentially important tool for the characterisation of cerebral tumours. The percentage of signal intensity recovery (PSR) and relative cerebral blood volume (rCBV) derived from DSC MRI provide information about tumour capillary permeability and neoangiogenesis, which can be used to characterise tumour type and grade, and distinguish tumour recurrence from treatment-related effects. Therefore, PSR and rCBV potentially represent a non-invasive means of diagnosis; however, the clinical utility of these parameters has yet to be established. We present a review of the literature to date.

show abstract

Evaluation of a supratentorial parenchymal lesion

Kim¹,

Gerstner²

2021

Neuro-Oncology for the Clinical Neurologist

View full text Add to dashboard Cite

Role of MRI perfusion in improving the treatment of brain tumors

Cited by 12 publications

References 132 publications

Advanced neuroimaging in the clinic: critical appraisal of the evidence base

Advanced neuroimaging in the clinic: critical appraisal of the evidence base

Accuracy of percentage of signal intensity recovery and relative cerebral blood volume derived from dynamic susceptibility-weighted, contrast-enhanced MRI in the preoperative diagnosis of cerebral tumours

Evaluation of a supratentorial parenchymal lesion

Contact Info

Product

Resources

About