Background: Multislice computed tomographic angiography (MCTA) has been increasingly used to detect and diagnose coronary artery atherosclerosis (CAD) because of its small size and tortuous continuous courses intimately related to the cardiac chambers. Objective: This work aimed to evaluate the accuracy of MCTA in assessing coronary artery Atherosclerosis. Patients and Methods: 50 patients attending our university hospitals with chest pain or suspected coronary artery disease were scheduled for an elective evaluation of coronary artery atherosclerosis. The coronary atherosclerosis was evaluated using MCTA, and the coronary artery calcium score (CACS) was analyzed and quantified. Results: Out of 50 patients (35 males & 15 females, with a mean age of 56 years) who reported chest pain that started recently, 15 patients (30%) had normal CTCA, 15 patients (30%), nonsignificant CAD, and 4 (8%) patients, had dense coronary calcification (CAD). Also, 15 (30%) patients had CACS=0, 3 (20%) of them with non-significant CAD, and 12 patients (80%) had normal CTCA. Among ten patients with CACS=1-99, 3 (30%) had significant CAD. Among 20 patients with CACS=100-399, 12 (60%) patients had significant CAD and one patient was seen with CACS=400-999 and had substantial CAD. Plaques were detected in 70 coronary vessels, out of which the LAD artery was the most commonly impaired at 29/70 (41.4%), followed by the RCA at 28.5% (20/70), the LCx at 17% (12/70), and the LM at 2/70 (2.8%). Conclusion: Multislice CT is a helpful, noninvasive method for evaluating coronary artery atherosclerosis.