Role of muscle damage on loading at the level adjacent to a lumbar spine fusion: a biomechanical analysis

Malakoutian, Masoud; Street, John; Wilke, Hans–Joachim; Stavness, Ian; Dvorak, Marcel F.; Fels, Sidney; Oxland, Thomas R.

doi:10.1007/s00586-016-4686-y

Cited by 30 publications

(29 citation statements)

References 62 publications

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“…This is why the posterior elements and ligaments are important in the maintenance of spinal stability. It has been established that posterior spinal surgery damages the paraspinal musculature, facet joint, and ligaments, causing limitations of ROM 9,17) . Thus, in clinical practice, postoperative posterior lumbar muscle damage plays an important role in the limitations of ROM.…”

Section: Discussionmentioning

confidence: 99%

Range of Motion According to the Fusion Level after Lumbar Spine Fusion: A Retrospective Study

Choi

Moon

Ryu

et al. 2018

Nerve

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The purpose of this study was to compare the range of motion (ROM) after spinal fusion according to the levels of lumbar spinal fusion (L4/5 and/or L5/S1). Methods: One hundred fifty-six patients were included in this study after undergoing thoracolumbar or lumbar fusion from April 2010 to December 2016. All patients had a numerical rating scale less than 4. We categorized the patients according to the fusion level for statistical purposes: 86 patients in group I with L4/5 or L3/4/5 fusion, 24 in group II with only L5/S1 fusion, 34 in group III with L4/5/S1 or L3/4/5/S1 fusion, and 12 in group IV with T10-S1 fusion for lesions. The ROM was evaluated by physicians of the rehabilitation medicine department using a blinded method, and the result was compared between each group. The student t-test was used in the statistical analysis. Results: The ROM of lumbar flexion was not different between each group, except for groups I and IV (p=0.038). The ROM of lumbar extension was statistically affected by fusion at the L4/5 or L5/S1 level. The ROM of lumbar lateral flexion had a tendency of being affected by fusion at the L4/5 or L5/S1 level. The ROM of lumbar lateral rotation was not affected by fusion at the L4/5 or L5/S1 level. Conclusion: The results suggest that the lower lumbar segments (L4/5 and especially L5/S1) contribute to spinal ROM (extension and lateral flexion), but these segments alone do not play significant roles in spinal flexion movements.

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Section: Discussionmentioning

confidence: 99%

Range of Motion According to the Fusion Level after Lumbar Spine Fusion: A Retrospective Study

Choi

Moon

Ryu

et al. 2018

Nerve

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“…(1) Injury stage: muscle injury due to various reasons, local hematoma formation, rupture of myofibrillar membrane, cell mass calcium overflow, increased calcium ion concentration in tissue fluid, activation of calcium-dependent protease and obstruction of mitochondrial respiratory function, and necrotic sites continuous damage. If the tissue is inflamed, macrophages will gather at the injury site and devour the diseased tissue [22]. (2) Repair stage: after muscle damage, the relevant stimulation signals are released, cell growth factors are secreted, and skeletal muscle satellite cells in the resting phase near the injury site are activated.…”

Section: Skeletal Muscle Injurymentioning

confidence: 99%

Muscle Injury in Bodybuilding Based on Mesoporous Multifunctional Nanomaterials for Sports Rehabilitation Training

Zhao

2020

Journal of Chemistry

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As an important means of treating diseases, chemical-based drugs have always guaranteed people’s health and longevity. However, due to the nature of some drugs, their use in the medical field is limited. This study mainly discusses the treatment of muscle damage based on sports rehabilitation training mesoporous multifunctional nanomaterials in bodybuilding. The biological characteristics of the targeted control of mesoporous multifunctional nanomaterials for target drugs were studied by analyzing the regeneration of skeletal muscles of mice after gastrocnemius strain under computer control. The electrostatic interactions modified by the consensus binding between AS1411 and Dimer-PPTcDA on the surface of mesoporous silicon are used to block the pores, and the release of objective molecules depends on the concentration of the drug in the tendon cells and the time of action. In this system, AS1411 has both the characteristics of the target substance and the active site of the targeted stimulus response in the cell. After FAM is labeled AS1411, the fluorescence of FAM can be used to monitor the release of the drug in real time, so as to directly release the drug to the lesion, maintain local effectiveness, and greatly improve the biological activity of the drug. In addition, in the safety analysis of mesoporous multifunctional nanomaterials on cells, if the concentration of nanoparticles is 90 μg/mL, the cell survival rate is almost 100%. The results show that the mesoporous multifunctional nanomaterials have low cytotoxicity and cell activity is not affected. The smaller the particle size of mesoporous silicon, the easier it is to invade the focus cells. In addition, confocal microscopy imaging has also effectively demonstrated the targeting effect of mesoporous multifunctional nanomaterials on cells.

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“…эти изменения, так называемая дисфункция параспинальных мышц, могут вызывать острую и хроническую боль в пояснице и дегенеративный спондилолистез [16,17]. Дегенерация смежного сегмента (aSD -ускоренный дегенеративный процесс) является серьезным осложнением, требующим высоких экономических затрат [18]. Внедрение новых технологий позволило развить такое направление, как динамическая стабилизация.…”

Section: Comparison Of Nitinol and Titanium Nails Effectiveness For Lunclassified

Comparison of Nitinol and Titanium Nails Effectiveness for Lumbosacral Spine Fixation in Surgical Treatment of Degenerative Spine Diseases

Kolesov

Kaz’min

Швец

et al. 2019

Traumatology and Orthopedics of Russia

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Relevance. Surgical decompression and decompression with stabilization are highly effective for treatment of spinal canal stenosis at the level of lumbar spine. However, complications developing after application of rigid fixation systems resulted in active introduction of dynamic implants into clinical practice.Purpose of the study — to compare effectiveness of nitinol and titanium nails for lumbosacral fixation in surgical treatment of degenerative spine diseases.Materials and methods. 220 patients who underwent surgeries in 4 hospitals were randomized into two groups, each consisting of 110 patients (1:1 ratio): a group of patients who underwent stabilization of the vertebral motor segments with rods of nitinol with the required volume of decompression at the operation level and a group of patients who underwent stabilization of the vertebral motor segments with standard rods of titanium with the required volume of decompression at the intervention level. Patients suffered clinically significant spinal canal stenosis in one or two adjacent segments: from L3 to S1. Outcomes were evaluated during three years postoperatively by VAS scale for spine and lower limbs, and by ODI and SF-36 scales.Results. All scales demonstrated better values in both groups of patients, namely, significant decrease of pain syndrome and improvement in mental and physical health. X-ray examination of all patients during the study period demonstrated restoration of lumbar lordosis. Group of patients with dynamic nails featured less complications rate related to metal implants including adjacent segment disease.Conclusion. Transpedicular fixation of lumbosacral spine by nitinol nails is an effective technique allowing to preserve motion along with stable fixation.

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Role of muscle damage on loading at the level adjacent to a lumbar spine fusion: a biomechanical analysis

Abstract: The results suggest that the paraspinal muscles of the lumbar spine play an important role in adjacent segment loading of a spinal fusion, independent of the presence of rigid spinal instrumentation.

Cited by 30 publications

References 62 publications

Range of Motion According to the Fusion Level after Lumbar Spine Fusion: A Retrospective Study

Range of Motion According to the Fusion Level after Lumbar Spine Fusion: A Retrospective Study

Muscle Injury in Bodybuilding Based on Mesoporous Multifunctional Nanomaterials for Sports Rehabilitation Training

Comparison of Nitinol and Titanium Nails Effectiveness for Lumbosacral Spine Fixation in Surgical Treatment of Degenerative Spine Diseases

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