Role of Muscular Strength on the Risk of Sudden Cardiac Death in Men

Jiménez-Pavón, David; Brellenthin, Angelique G.; Lee, Duck-chul; Sui, Xuemei; Blair, Steven N.; Lavie, Carl J.

doi:10.1016/j.mayocp.2019.09.023

Cited by 19 publications

(17 citation statements)

References 10 publications

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“…Patients with higher muscle strength have significant lower risk of type 2 diabetes 42 . In addition, the incidence of sudden cardiac death decreases by 69% for those with middle third of muscle strength compared with the lower third of muscle strength 43 . Lower incidence of heart failure is also observed in patients with higher handgrip strength 44 .…”

Section: Discussionmentioning

confidence: 99%

“…42 In addition, the incidence of sudden cardiac death decreases by 69% for those with middle third of muscle strength compared with the lower third of muscle strength. 43 Lower incidence of heart failure is also observed in patients with higher handgrip strength. 44 However, there is a paucity of previous studies to systematically analyse the impacts of HGS on various cancer types.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical impacts of muscle strength have been well studied in non-malignant diseases, such as diabetes 42 and cardiovascular diseases. [43][44][45][46] Patients with higher muscle strength have significant lower risk of type 2 diabetes. 42 In addition, the incidence of sudden cardiac death decreases by 69% for those with middle third of muscle strength compared with the lower third of muscle strength.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical impacts of muscle strength have been well studied in non‐malignant diseases, such as diabetes 42 and cardiovascular diseases 43–46 . Patients with higher muscle strength have significant lower risk of type 2 diabetes 42 .…”

Section: Discussionmentioning

confidence: 99%

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Associations of low handgrip strength with cancer mortality: a multicentre observational study

Zhuang

Zhang

et al. 2020

J cachexia sarcopenia muscle

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Background Handgrip strength (HGS) is associated with poor clinical outcomes, including all-cause, non-cardiovascular, and cardiovascular mortalities. The published cutoff points for HGS are mostly based on community populations from Western countries, lacking information on cancer patients from China. The objective of this study was to establish sex-specific cutoff points for Chinese cancer patients and investigate the effect of low HGS on cancer mortality. Methods We did a retrospective cohort study of patients who were diagnosed with malignant cancer from June 2012 to December 2018. HGS was measured using a hand dynamometer in 8257 cancer patients. Optimal stratification was used to solve threshold points. The hazard ratio (HR) of all cancer mortality and cancer-specific mortality was calculated using Cox proportional hazard regression models. Results Among all participants, there were 3902 (47.3%) women and 4355 (52.7%) men. The median age was 58 years old. The cutoff points of HGS to best classify patients with respect to time to mortality were <16.1 kg for women and <22 kg for men. Low HGS was associated with overall cancer mortality in both women and men [

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Associations of low handgrip strength with cancer mortality: a multicentre observational study

Zhuang

Zhang

et al. 2020

J cachexia sarcopenia muscle

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“…Conversely, lower muscular strength in late adolescence/early adulthood (i. e., age 18 years) is a significant predictor of the development of heart failure [7] and CVD events later in life, independent of cardiorespiratory fitness [8]. The great majority of studies exploring the cardio-vascular health benefits of muscular strength have been done exclusively in men [9][10][11][12][13]. There are established sex differences in muscle mass, neuromuscular strength, and cardiovascular function, and these differences change across the lifespan.…”

Section: Introductionmentioning

confidence: 99%

The Inverse Association of Muscular Strength with Carotid Intima-media and Extra-media Thickness in Women

et al. 2020

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The purpose of this study was to determine the relationship between strength and atherosclerotic cardiovascular disease (CVD) risk in young women. Carotid intima-media thickness (IMT) and extra-media thickness (EMT) were used as measures of subclinical atherosclerosis and CVD risk. Muscular strength, IMT, and EMT were measured in 70 young women (mean age=21±4 years). Strength was determined using a handgrip dynamometer and expressed relative to body mass. IMT and EMT were measured using ultrasonography of the left common carotid artery. Objectively measured moderate-vigorous physical activity (MVPA) was assessed with accelerometry. Higher relative handgrip strength was associated with lower IMT (r=−0.23; p<0.05) and lower EMT (r=−0.27; p<0.05). Associations between relative handgrip strength and IMT (r=−0.24) as well as EMT (r=−0.25) remained significant after adjusting for potential confounders including traditional CVD risk factors and MVPA (p<0.05). These results show that there is an inverse association between handgrip strength with carotid IMT and EMT in young women. Muscular strength may reduce CVD risk in young women via favorable effects on subclinical carotid atherosclerosis independent of physical activity.

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Hand grip strength in patients with advanced cancer: A prospective study

Hadzibegovic

Porthun

Lena

et al. 2023

J cachexia sarcopenia muscle

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Background Hand grip strength (HGS) is a widely used functional test for the assessment of strength and functional status in patients with cancer, in particular with cancer cachexia. The aim was to prospectively evaluate the prognostic value of HGS in patients with mostly advanced cancer with and without cachexia and to establish reference values for a European‐based population. Methods In this prospective study, 333 patients with cancer (85% stage III/IV) and 65 healthy controls of similar age and sex were enrolled. None of the study participants had significant cardiovascular disease or active infection at baseline. Repetitive HGS assessment was performed using a hand dynamometer to measure the maximal HGS (kilograms). Presence of cancer cachexia was defined when patients had ≥5% weight loss within 6 months or when body mass index was <20.0 kg/m2 with ≥2% weight loss (Fearon's criteria). Cox proportional hazard analyses were performed to assess the relationship of maximal HGS to all‐cause mortality and to determine cut‐offs for HGS with the best predictive power. We also assessed associations with additional relevant clinical and functional outcome measures at baseline, including anthropometric measures, physical function (Karnofsky Performance Status and Eastern Cooperative of Oncology Group), physical activity (4‐m gait speed test and 6‐min walk test), patient‐reported outcomes (EQ‐5D‐5L and Visual Analogue Scale appetite/pain) and nutrition status (Mini Nutritional Assessment). Results The mean age was 60 ± 14 years; 163 (51%) were female, and 148 (44%) had cachexia at baseline. Patients with cancer showed 18% lower HGS than healthy controls (31.2 ± 11.9 vs. 37.9 ± 11.6 kg, P < 0.001). Patients with cancer cachexia had 16% lower HGS than those without cachexia (28.3 ± 10.1 vs. 33.6 ± 12.3 kg, P < 0.001). Patients with cancer were followed for a mean of 17 months (range 6–50), and 182 (55%) patients died during follow‐up (2‐year mortality rate 53%) (95% confidence interval 48–59%). Reduced maximal HGS was associated with increased mortality (per −5 kg; hazard ratio [HR] 1.19; 1.10–1.28; P < 0.0001; independently of age, sex, cancer stage, cancer entity and presence of cachexia). HGS was also a predictor of mortality in patients with cachexia (per −5 kg; HR 1.20; 1.08–1.33; P = 0.001) and without cachexia (per −5 kg; HR 1.18; 1.04–1.34; P = 0.010). The cut‐off for maximal HGS with the best predictive power for poor survival was <25.1 kg for females (sensitivity 54%, specificity 63%) and <40.2 kg for males (sensitivity 69%, specificity 68%). Conclusions Reduced maximal HGS was associated with higher all‐cause mortality, reduced overall functional status and decreased physical performance in patients with mostly advanced cancer. Similar results were found for patients with and without cancer cachexia.

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Role of Muscular Strength on the Risk of Sudden Cardiac Death in Men

Cited by 19 publications

References 10 publications

Associations of low handgrip strength with cancer mortality: a multicentre observational study

Associations of low handgrip strength with cancer mortality: a multicentre observational study

The Inverse Association of Muscular Strength with Carotid Intima-media and Extra-media Thickness in Women

Hand grip strength in patients with advanced cancer: A prospective study

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