Role of mushrooms in gestational diabetes mellitus

Gulati, Vandana; Singh, Mansi Dass; Gulati, Pankaj

doi:10.3934/medsci.2019.1.49

Cited by 11 publications

(7 citation statements)

References 56 publications

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“…Among them, the structures of eight compounds were determined using UPLC-MS 2 and references as poricoic acid B, dehydrotumulosic acid, poricoic acid A, polyporenic acid C, 3- epidehydrotumulosic acid, dehydropachymic acid, 3-O-acetyl-16α-hydroxytrametenolic acid, and pachymic acid, respectively. According to many types of research, most of them, including dehydrotumulosic acid, polyporenic acid C, pachymic acid, dehydrotrametenolic acid, and dehydroeburicoic acid, could act as an insulin sensitizer in glucose tolerance tests and reduce hyperglycemia ( 42 , 43 ). Xie et al extracted poricoic acid A from Sargassum pallidum and also found the inhibitory effect of poricoic acid A on α-glucosidase ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Rapid identification of α-glucosidase inhibitors from Poria using spectrum-effect, component knock-out, and molecular docking technique

Lü

Ren

et al. 2023

Front. Nutr.

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InstructionPoria (Poria cocos) is known for its health-promoting effects and is consumed as a food due to its potential hypoglycemic activity. However, the composition of Poria is complex, and the bioactive compounds that inhibit α-glucosidase are not clear.MethodsIn this study, the fingerprint of the Poria methanol extract characterized by high-performance liquid chromatography (HPLC) and the model of the corresponding spectrum-effect relationship for α-glucosidase was first established to screen the active compounds from Poria. Then, the predicted bioactive compounds were knocked out and identified using mass spectrometry. Finally, the potential binding sites and main bonds of each compound with α-glucosidase were studied using molecular docking.ResultsThe results have shown that at least 11 compounds from Poria could inhibit α-glucosidase effectively. Moreover, eight individual compounds, i.e., poricoic acid B (P8), dehydrotumulosic acid (P9), poricoic acid A (P10), polyporenic acid C (P12), 3- epidehydrotumulosic acid (P13), dehydropachymic acid (P14), 3-O-acetyl-16α-hydroxytrametenolic acid (P21), and pachymic acid (P22), were identified, and they exhibited effective inhibitory activity against α-glucosidase.DiscussionThe possible inhibitory mechanism of them based on molecular docking showed that the binding sites are mainly found in the rings A, B, and C of these compounds, and C-3 C-16 and side chains of C-17, with the phenylalanine, arginine, tyrosine, histidine, and valine of α-glucosidase. The main interactions among them might be alkyl and hydrogen bonds, which theoretically verified the inhibitory activity of these compounds on α-glucosidase. The achievements of this study provided useful references for discovering bioactive compounds with hypoglycemic effects from Poria.

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Section: Discussionmentioning

confidence: 99%

Rapid identification of α-glucosidase inhibitors from Poria using spectrum-effect, component knock-out, and molecular docking technique

Lü

Ren

et al. 2023

Front. Nutr.

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“…Increased and chronic inflammation in the body may originate insulin resistance and alter its action which can lead to a cluster of several metabolic conditions, including diabetes and cardiovascular diseases. Mushrooms are rich in soluble and insoluble fiber, which is known to maintain and reduce the body's blood sugar level being effective in controlling glycaemic levels ( 165 ).…”

Section: Diabetesmentioning

confidence: 99%

“…Coriolus versicolor ( Figure 11 ) and Hericium erinaceus have been the subject of neurobiological research on the control of redox-dependent genes, so-called the vitagene family, measuring heat shock proteins, superoxide dismutase, glutathione and thioredoxin systems, lipoxin A4, and sirtuins, as potential neuro-therapeutic targets ( 165 , 175 ).…”

Section: Neuroprotective Aptitude Of Mushroomsmentioning

confidence: 99%

Mushrooms as future generation healthy foods

Bell

Silva

Guina³

et al. 2022

Front. Nutr.

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The potential of edible mushrooms as an unexploited treasure trove, although rarely included in known food guidelines, is highlighted. Their role in shielding people against the side effects of an unhealthy stylish diet is reviewed. Mushrooms complement the human diet with various bioactive molecules not identified or deficient in foodstuffs of plant and animal sources, being considered a functional food for the prevention of several human diseases. Mushrooms have been widely used as medicinal products for more than 2,000 years, but globally the potential field of use of wild mushrooms has been untapped. There is a broad range of edible mushrooms which remain poorly identified or even unreported which is a valuable pool as sources of bioactive compounds for biopharma utilization and new dietary supplements. Some unique elements of mushrooms and their role in preventative healthcare are emphasized, through their positive impact on the immune system. The potential of mushrooms as antiviral, anti-inflammatory, anti-neoplastic, and other health concerns is discussed. Mushrooms incorporate top sources of non-digestible oligosaccharides, and ergothioneine, which humans are unable to synthesize, the later a unique antioxidant, cytoprotective, and anti-inflammatory element, with therapeutic potential, approved by world food agencies. The prebiotic activity of mushrooms beneficially affects gut homeostasis performance and the balance of gut microbiota is enhanced. Several recent studies on neurological impact and contribution to the growth of nerve and brain cells are mentioned. Indeed, mushrooms as functional foods' nutraceuticals are presently regarded as next-generation foods, supporting health and wellness, and are promising prophylactic or therapeutic agents.

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“…Many previous studies evaluated the effects of lectins on the immune system. For instance, the injections of 10 μg lectins in intraperitoneal tissue for ten days upregulated the transforming growth factor-β, interleukin (IL)-1β, and nitric oxide synthetase expression level [69]. The immunomodulatory properties of L. mongolica are due to its rich bioactive compounds.…”

Section: Immune Activitymentioning

confidence: 99%

Bioactive Compounds in <em>Leucocalocybe mongolica</em> Pharmacological and Therapeutic Applications

Haiying¹,

Mt²,

Ah³

2021

Preprint

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Medicinal mushrooms have got much attention from biologists in the last decades. Leucocalocybe mongolica Imai remains one of the famous clinical and edible mushrooms used in traditional Chinese medicine and Mongolian medicine to treat various diseases. It also commonly consumes in Chinese and Mongolian daily dishes. Numerous biochemical components exist in L. mongolica, especially in the fruiting bodies include; polysaccharides, sterol, lectins, laccase, amino acids, terpenes, volatile compounds, and so on. These biomedical components possess a lot of medicinal properties and provide diverse therapeutical effects for human health, such as anti-tumor activity, antiproliferative activity, anti-diabetes properties, hypotensive effect, hepatoprotective effect, antioxidant activity, cardioprotective effect, and so on. However, this review's main objectives are to illustrate some basics about the bioactive components in L. mongolica and its pharmacological effects on the human body. In addition to giving forward some suggestions for future research on this medicinal mushroom.

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Role of mushrooms in gestational diabetes mellitus

Cited by 11 publications

References 56 publications

Rapid identification of α-glucosidase inhibitors from Poria using spectrum-effect, component knock-out, and molecular docking technique

Rapid identification of α-glucosidase inhibitors from Poria using spectrum-effect, component knock-out, and molecular docking technique

Mushrooms as future generation healthy foods

Bioactive Compounds in <em>Leucocalocybe mongolica</em> Pharmacological and Therapeutic Applications

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