Role of MYC-Regulated Long Noncoding RNAs in Cell Cycle Regulation and Tumorigenesis

Abstract

Our results provide novel regulatory mechanisms in MYC function through lncRNAs and new potential lncRNA targets of CRC.

A Long Noncoding RNA Regulates Sister Chromatid Cohesion

“…LncRNAs described until now have been shown to be involved in the most diverse cellular processes, such as cell growth and apoptosis, cell pluripotency, and differentiation, through multiple and diverse mechanisms (Bonasio and Shiekhattar, 2014; Fatica and Bozzoni, 2014; Rinn and Chang, 2012). Moreover, our work and that of others has shown that lncRNAs are key regulators of cell transformation and, in some cases, direct transcriptional targets of well-known tumor suppressor and oncogenic factors, such as p53 (Huarte, 2015; Sánchez et al, 2014) and MYC (Hart et al, 2014; Kim et al, 2015). …”

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

“…Accumulating evidence shows that lncRNAs are involved in physiological and pathological progresses, including embryonic development, organ formation, X chromatin inactivation, tumorigenesis and so on refs 12, 13, 14, 15. LncRNAs can recruit transcription factors and remodelling complexes to modulate gene expression11 and they can also interact with messenger RNAs and regulate the stability of mRNAs.…”

Comprehensive site-specific whole genome profiling of stromal and epithelial colonic gene signatures in human sigmoid colon and rectal tissue

“…In addition, other lncRNAs can also act as decoys, sequestering intracellular mediators and suppressing their ability to fulfill tumor suppressor functions (10). Recently, several studies have identified clinically relevant lncRNAs in CRC, e.g., serve as prognostic biomarkers (25,30,51,57). To date, a genome-wide transcriptional profiling of the stromal and epithelial colonic coding and noncoding gene signatures in human sigmoid colon and rectal tissue has not been performed.…”