Role of Mycoplasma genitalium and Ureaplasma urealyticum in Acute and Chronic Nongonococcal Urethritis

Abstract

One hundred fourteen heterosexual men with acute nongonococcal urethritis (NGU) and 64 patients without NGU were studied. We determined that Chlamydia trachomatis and Mycoplasma genitalium were strongly associated with acute NGU after controlling, by means of multivariate analysis, for age, race, sexual lifestyle, and coinfection (odds ratio [OR], 13.0, 95% confidence interval [CI], 2.6-64.5; and OR, 17.9, 95% CI, 2.0-160, respectively). Eighty-six men with acute NGU reattended at least once 10-92 days after treatment; 59 (69%) of these 86 men had urethritis. Seven men had M. genitalium detected during 10-92 days of follow-up, and all had urethritis. Ureaplasmas were not associated with acute NGU in multivariate analysis, but their detection was associated with the presence of urethritis during follow-up (P=.014). Ureaplasmas or M. genitalium were associated with both chronic NGU, which was defined as urethritis that occurred 30-92 days after the commencement of treatment (P=.028), and chronic NGU with symptoms or signs (P=.005).

Aplicación de método molecular en la detección de Mycoplasma genitalium en hombres y en mujeres embarazadas

“…El 15 a 25% de los casos agudos de UNG serían causados por M. genitalium y un porcentaje no bien determinado por Ureaplasma sp [5][6][7][8][9]21 .…”

“…Entre 20 y 60% de los pacientes con UNG aguda, aún tratados con una terapia antimicrobiana apropiada, desarrollan una uretritis crónica, siendo M. genitalium y Ureaplasma sp los agentes más frecuentemente detectados 21 . Hooton y cols investigaron mediante hibridación con sondas de ADN la presencia de M. genitalium en 203 hombres con diferentes tipos de uretritis, determinando la prevalencia del microorganismo según las preferencias sexuales de los pacientes.…”

Genital Chlamydia trachomatis infections

“…è responsabile di circa il 50% delle uretriti non specifiche (non gonococciche e post gonococciche) (54,93,110). Decorre nel 30-50% dei casi in modo asintomatico o con sintomi lievi e banali (39).…”

Longitudinal Quantitative Detection by Real-Time PCR of Mycoplasma genitalium in First-Pass Urine of Men with Recurrent Nongonococcal Urethritis

“…We reported that the M. genitalium load was significantly higher in men with acute nonchlamydial NGU than in asymptomatic men (17). The various results reported to date suggest that M. genitalium may be associated with the development of acute NGU independent of Chlamydia trachomatis (2, 13).For chronic NGU, it has been suggested that persistence of M. genitalium in the urethra after antimicrobial chemotherapy might be associated with this condition (5,7,10,15). However, quantitative analysis of M. genitalium has been not performed in cases of chronic NGU.…”

“…For chronic NGU, it has been suggested that persistence of M. genitalium in the urethra after antimicrobial chemotherapy might be associated with this condition (5,7,10,15). However, quantitative analysis of M. genitalium has been not performed in cases of chronic NGU.…”