2004
DOI: 10.1080/10428190410001723317
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Role of Myeloid Cell Factor-1 (Mcl-1) in Chronic Lymphocytic Leukemia

Abstract: The primary abnormality in chronic lymphocytic leukemia (CLL) is a defect in apoptosis, probably related to alterations in the expressions of Bcl-2 family members. In transgenic mice over expressing the anti-apoptotic Bcl-2 family member, myeloid cell factor-1 (Mcl-1), B cell lymphomas occur. Moreover, mice conditional for the loss of Mcl-1 display a profound reduction in B and T lymphocytes. This suggests that Mcl-1 is an essential survival factor in lymphocytes. In the present study, we have evaluated the ro… Show more

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Cited by 34 publications
(25 citation statements)
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“…MCL1 has been extensively studied and is a BCL2 family protein that has antiapoptotic function. 10 It has been implicated in conferring resistance to chemotherapy in chronic lymphocytic leukemia, [24][25][26] and overexpression of MCL1 promotes tumorigenesis in a transgenic mice model. 27 High levels of MCL1 expression has been found in several types of malignant lymphoma, including anaplastic large cell lymphoma 28 and mantle cell lymphoma.…”
Section: Discussionmentioning
confidence: 99%
“…MCL1 has been extensively studied and is a BCL2 family protein that has antiapoptotic function. 10 It has been implicated in conferring resistance to chemotherapy in chronic lymphocytic leukemia, [24][25][26] and overexpression of MCL1 promotes tumorigenesis in a transgenic mice model. 27 High levels of MCL1 expression has been found in several types of malignant lymphoma, including anaplastic large cell lymphoma 28 and mantle cell lymphoma.…”
Section: Discussionmentioning
confidence: 99%
“…This signature (which includes Ϸ2% of the down-regulated genes in MEG-01 and Ϸ11% of those repressed in patients) contains oncogenes such as MCL1, JUN, SCAP2, TRA1, PDCD6IP, RAD51C, and HSPA1A/1B, which could explain the oncosuppressor effect of miR-15a/16-1 observed in MEG-01 both in vitro (22),and in vivo (present work). MCL1 is an antiapoptotic BCL-2 family member that contributes to B cell survival in CLL and has been associated with resistance to chemotherapy (35,36). Despite the fact that MCL-1 expression is not different in ZAP 70-positive (aggressive) vs.…”
Section: Variation Of Expression Of Mir-15a/mir 16-1 Targets In Primamentioning
confidence: 99%
“…However, bfl-1 expression correlated with in vivo response to chlorambucil. Previously, Mcl-1 expression was reported to correlate to in vitro chlorambucilinduced apoptosis but not to fludarabine-induced apoptosis (Johnston et al, 2004). Although both drugs induce apoptosis through a mitochondria-dependent pathway, initiation of the pathway may depend on different mechanisms, which might be selectively counteracted by bfl-1 or mcl-1.…”
Section: Discussionmentioning
confidence: 97%