Role of myeloid-derived suppressor cells in viral respiratory infections; Hints for discovering therapeutic targets for COVID-19

Koushki, Khadijeh; Salemi, Maryam; Miri, Seyed Mohammad; Arjeini, Yaser; Keshavarz, Mohsen; Ghaemi, Amir

doi:10.1016/j.biopha.2021.112346

Cited by 31 publications

(31 citation statements)

References 125 publications

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“…Myeloid-derived suppressor cells (MDSCs) are an important monocyte subset recruited from the periphery into the airways during infection ( Koushki et al., 2021 ). MDSCs are heterologous immunosuppressor cells of myeloid origin distinguished in humans by expression of CD34 + CD11b + CD33 + human leukocyte antigen (HLA)-DR − and categorized as either CD14 − CD15 + granulocytic (PMN/G-MDSC) or CD14 + monocytic (M-MDSC) ( Bergenfelz and Leandersson, 2020 ).…”

Section: Innate Respiratory Response: Recruited and Dynamic Recircula...mentioning

confidence: 99%

“…MDSCs are heterologous immunosuppressor cells of myeloid origin distinguished in humans by expression of CD34 + CD11b + CD33 + human leukocyte antigen (HLA)-DR − and categorized as either CD14 − CD15 + granulocytic (PMN/G-MDSC) or CD14 + monocytic (M-MDSC) ( Bergenfelz and Leandersson, 2020 ). Depending on the subset, MDSCs are capable of producing arginase-I, reactive oxygen, and nitrogen species and, as their name suggests, are involved in establishing an immune-suppressed local environment through production of IL10 and TGFβ and recruitment of Treg cells ( Koushki et al., 2021 ). MDSC function can have pleiotropic effects on other respiratory immune cells, including downregulation of IL12 signaling in macrophages leading to a suppressive phenotype, reducing NK cell cytotoxic functions and development, and reducing adaptive lymphocyte recruitment and response via stymied DC development ( Koushki et al., 2021 ).…”

Section: Innate Respiratory Response: Recruited and Dynamic Recircula...mentioning

confidence: 99%

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Mucosal immune responses to infection and vaccination in the respiratory tract

Mettelman

Allen²,

Thomas³

2022

Immunity

123

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Section: Innate Respiratory Response: Recruited and Dynamic Recircula...mentioning

confidence: 99%

Section: Innate Respiratory Response: Recruited and Dynamic Recircula...mentioning

confidence: 99%

Mucosal immune responses to infection and vaccination in the respiratory tract

Mettelman

Allen²,

Thomas³

2022

Immunity

123

View full text Add to dashboard Cite

“…Furthermore, intensive care patients with severe COVID-19 had a lower number of innate and adaptive cytotoxic cells such as natural killer cells and T-lymphocytes, and this effect was in line with CD33 expansion and rising levels of cytokines. Frequency of CD33 was positively correlated to viral load and length of hospitalization, and negatively correlated to T cell count, natural killer cell count, and serum albumin (Koushki et al 2021 ). Demographics [sex (female 49%, male %51), age (mean age 54 ± 9.2 years), deceased to COVID-19, comorbidities (Alzheimer’s disease, coronary heart disease, and hypertension)] may be confounding factors in that study.…”

Section: Methodsmentioning

confidence: 99%

The relationship of early- and late-onset Alzheimer’s disease genes with COVID-19

2022

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Individuals with Alzheimer’s disease and other neurodegenerative diseases have been exposed to excess risk by the COVID-19 pandemic. COVID-19’s main manifestations include high body temperature, dry cough, and exhaustion. Nevertheless, some affected individuals may have an atypical presentation at diagnosis but suffer neurological signs and symptoms as the first disease manifestation. These findings collectively show the neurotropic nature of SARS-CoV-2 virus and its ability to involve the central nervous system. In addition, Alzheimer’s disease and COVID-19 has a number of common risk factors and comorbid conditions including age, sex, hypertension, diabetes, and the expression of APOE ε4. Until now, a plethora of studies have examined the COVID-19 disease but only a few studies has yet examined the relationship of COVID-19 and Alzheimer’s disease as risk factors of each other. This review emphasizes the recently published evidence on the role of the genes of early- or late-onset Alzheimer’s disease in the susceptibility of individuals currently suffering or recovered from COVID-19 to Alzheimer’s disease or in the susceptibility of individuals at risk of or with Alzheimer’s disease to COVID-19 or increased COVID-19 severity and mortality. Furthermore, the present review also draws attention to other uninvestigated early- and late-onset Alzheimer’s disease genes to elucidate the relationship between this multifactorial disease and COVID-19.

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“…MDSCs present at very low levels in healthy individuals because of the rapid differentiation into mature myeloid cells. However, in the presence of pathological conditions, such as malignancies, infections, bone marrow transplantation, or some autoimmune diseases, MDSC levels are highly increased due to inhibition of their differentiation into mature myeloid cells [ 76 , 77 ]. Interestingly, when activated in a pathogenic situation, these cells overexpress immune inhibitory factors such as nitric oxide synthase (NOS), arginase 1 (ARG1), and peroxynitrite (ONOO − ) [ 76 , 78 ].…”

Section: Myeloid-derived Suppressor Cells (Mdscs)mentioning

confidence: 99%

Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19

Alsalman

Al-Mterin

Elkord

2022

Journal of Immunology Research

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Coronavirus disease 2019 (COVID-19) has been raised as a pandemic disease since December 2019. Immunosuppressive cells including T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs) are key players in immunological tolerance and immunoregulation; however, they contribute to the pathogenesis of different diseases including infections. Tregs have been shown to impair the protective role of CD8+ T lymphocytes against viral infections. In COVID-19 patients, most studies reported reduction, while few other studies found elevation in Treg levels. Moreover, Tregs have a dual role, depending on the different stages of COVID-19 disease. At early stages of COVID-19, Tregs have a critical role in decreasing antiviral immune responses, and consequently reducing the viral clearance. On the other side, during late stages, Tregs reduce inflammation-induced organ damage. Therefore, inhibition of Tregs in early stages and their expansion in late stages have potentials to improve clinical outcomes. In viral infections, MDSC levels are highly increased, and they have the potential to suppress T cell proliferation and reduce viral clearance. Some subsets of MDSCs are expanded in the blood of COVID-19 patients; however, there is a controversy whether this expansion has pathogenic or protective effects in COVID-19 patients. In conclusion, further studies are required to investigate the role and function of immunosuppressive cells and their potentials as prognostic biomarkers and therapeutic targets in COVID-19 patients.

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Role of myeloid-derived suppressor cells in viral respiratory infections; Hints for discovering therapeutic targets for COVID-19

Cited by 31 publications

References 125 publications

Mucosal immune responses to infection and vaccination in the respiratory tract

Mucosal immune responses to infection and vaccination in the respiratory tract

The relationship of early- and late-onset Alzheimer’s disease genes with COVID-19

Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19

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