Role of Myosins in Depression of Sensitivity ofHelixNeurons to Acetylcholine in a Cellular Analog of Habituation

Possibility of “Comet-Like” Transport of Acetylcholine Receptors in Command <i>Helix</i> Neurons in Cellular Analog of Habituation

“…However, in this study, it is not possible to draw a conclusion about the share of each of the two types of vesicle-containing receptors. We can't count it because 1) rates of receptor transport along the membrane and of receptor exocytosis change along with receptor endocytosis rate change; and 2) according to our earlier studies, inhibition of light myosin chains likewise led to the reduction of the rate of ACh-current depression stabilization [23].…”

“…Our earlier results allowed us to suspect an existence of radial acetylcholine receptor transport with the involvement of myosin motors along actin filaments in command neurons of a land snail (Helix lucorum) in a cellular analog of habituation [23]. Given that the presence of N-WASP protein was shown in the neurons of marine mollusk Aplysia [24], the possibility of the second aforesaid mechanism of receptor transport by actin filaments (without myosin involvement) in the neurons of a land mollusk cannot be excluded.…”