2009
DOI: 10.1007/s12072-009-9151-0
|View full text |Cite
|
Sign up to set email alerts
|

Role of N-acetylcysteine in adults with non-acetaminophen-induced acute liver failure in a center without the facility of liver transplantation

Abstract: The use of NAC causes reduction in NAI-ALF mortality and its use was safe.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

3
85
0
1

Year Published

2010
2010
2023
2023

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 85 publications
(89 citation statements)
references
References 22 publications
3
85
0
1
Order By: Relevance
“…
We read with interest the article by Mumtaz et al [1] on the role of oral N-acetylcysteine (NAC) in adults with nonacetaminophen-induced acute liver failure. We agree that their findings are of particular relevance to many developing countries, where liver transplantation is neither available nor affordable.
…”
mentioning
confidence: 99%
“…
We read with interest the article by Mumtaz et al [1] on the role of oral N-acetylcysteine (NAC) in adults with nonacetaminophen-induced acute liver failure. We agree that their findings are of particular relevance to many developing countries, where liver transplantation is neither available nor affordable.
…”
mentioning
confidence: 99%
“…N-acetylcysteine(NAC), a precursor of Glutathione, has also shown some success in patients with NonAcetaminophen-induced Acute liver failure(NAI-ALF), attributed to its anti-inflammatory, anti-oxidant, inotropic and vasodilatory effects which improve the microcirculation and oxygenation of vital organs, providing a survival benefit, as reported by Mumtaz K. et al following a prospective study of 47 patients with NAI-ALF. 21 Novel treatment modalities such as plasmapheresis and the use of activated protein C have been practiced in specialized centers, with variable outcomes. [22][23][24] According to a report by R.S.M Mohommad et al, on 3 cases of AFLP complicated with multiorgan failure, treated with repeated sessions of plasmapheresis, the results look promising, but this modality of treatment still needs to be explored in detail.…”
Section: Discussionmentioning
confidence: 99%
“…Hence, there may have been some benefit of using NAC in our patient. 10 Other strategies suggested for managing prolonged hypoglycaemia following insulin overdose include surgical excision of the depot site, the use of glucocorticoids to induce insulin resistance and the use of glucagon to alleviate the need for glucose loading. 2,4 The obvious dearth of reported literature and limited knowledge in this area can lead to unnecessary investigations, anxiety for the patient and also prolonged hospital length of stay.…”
Section: Discussionmentioning
confidence: 99%