Role of NAADP for calcium signaling in the salivary gland

Imbery, John F.; Iqbal, Azwar K.; Desai, Tanvi; Giovannucci, David R.

doi:10.1016/j.ceca.2019.03.001

Cited by 4 publications

(2 citation statements)

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“…Ca 2+ surges released from internal stores during mammalian egg fertilization stimulates a signaling cascade resulting in the completion of meiosis and triggers specific mitotic events in the development of the embryo (Miyazaki et al, 1993;Swanson et al, 1997;Jones et al, 2000). Primary saliva production in parotid acinar cells is dependent on the coordination of intracellular Ca 2+ signaling (Imbery et al, 2019). Finally, disruption of Ca 2+ signaling can induce apoptosis through a complex interplay involving Ca 2+ activated proteases, phospholipases, and endonucleases (Kass and Orrenius, 1999).…”

Section: Na + /Glucose Transporter (Sglt)mentioning

confidence: 99%

Sodium Transporters in Human Health and Disease

Gagnon

Delpire

2021

Front. Physiol.

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Sodium (Na+) electrochemical gradients established by Na+/K+ ATPase activity drives the transport of ions, minerals, and sugars in both excitable and non-excitable cells. Na+-dependent transporters can move these solutes in the same direction (cotransport) or in opposite directions (exchanger) across both the apical and basolateral plasma membranes of polarized epithelia. In addition to maintaining physiological homeostasis of these solutes, increases and decreases in sodium may also initiate, directly or indirectly, signaling cascades that regulate a variety of intracellular post-translational events. In this review, we will describe how the Na+/K+ ATPase maintains a Na+ gradient utilized by multiple sodium-dependent transport mechanisms to regulate glucose uptake, excitatory neurotransmitters, calcium signaling, acid-base balance, salt-wasting disorders, fluid volume, and magnesium transport. We will discuss how several Na+-dependent cotransporters and Na+-dependent exchangers have significant roles in human health and disease. Finally, we will discuss how each of these Na+-dependent transport mechanisms have either been shown or have the potential to use Na+ in a secondary role as a signaling molecule.

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Section: Na + /Glucose Transporter (Sglt)mentioning

confidence: 99%

Sodium Transporters in Human Health and Disease

Gagnon

Delpire

2021

Front. Physiol.

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“…Like IP 3 , both nucleotide messengers are known to regulate a wide range of physiological functions and in a variety of cell types spanning three biological kingdoms (reviewed in Refs. [11][12][13][14][15][16], including mediating the adrenergic receptor activation in the salivary gland (17) and the hippocampal mGluR1-dependent long-term potentiation (18), shown recently.…”

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confidence: 99%

Resolving the topological enigma in Ca2+ signaling by cyclic ADP-ribose and NAADP

Lee

Zhao

2019

Journal of Biological Chemistry

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Edited by Mike Shipston Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two structurally distinct messengers that mobilize the endoplasmic and endolysosomal Ca 2؉ stores, respectively. Both are synthesized by the CD38 molecule (CD38), which has long been thought to be a type II membrane protein whose catalytic domain, intriguingly, faces to the outside of the cell. Accordingly, for more than 20 years, it has remained unresolved how CD38 can use cytosolic substrates such as NAD and NADP to produce messengers that target intracellular Ca 2؉ stores. The discovery of type III CD38, whose catalytic domain faces the cytosol, has now begun to clarify this topological conundrum. This article reviews the ideas and clues leading to the discovery of the type III CD38; highlights an innovative approach for uncovering its natural existence; and discusses the regulators of its activity, folding, and degradation. We also review the compartmentalization of cADPR and NAADP biogenesis. We further discuss the possible mechanisms that promote type III CD38 expression and appraise a proposal of a Ca 2؉-signaling mechanism based on substrate limitation and product translocation. The surprising finding of another enzyme that produces cADPR and NAADP, sterile ␣ and TIR motif-containing 1 (SARM1), is described. SARM1 regulates axonal degeneration and has no sequence similarity with CD38 but can catalyze the same set of multireactions and has the same cytosolic orientation as the type III CD38. The intriguing finding that SARM1 is activated by nicotinamide mononucleotide to produce cADPR and NAADP suggests that it may function as a regulated Ca 2؉-signaling enzyme like CD38.

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Enzymatic and Endogenous Synthesis of Nad(p)‐derived Calcium‐mobilizing Messengers

Lee¹,

Zhao²

2022

Nucleic Acids in Medicinal Chemistry and Chemical Biology

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Role of NAADP for calcium signaling in the salivary gland

Cited by 4 publications

References 58 publications

Sodium Transporters in Human Health and Disease

Sodium Transporters in Human Health and Disease

Resolving the topological enigma in Ca2+ signaling by cyclic ADP-ribose and NAADP

Enzymatic and Endogenous Synthesis of Nad(p)‐derived Calcium‐mobilizing Messengers

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