Role of Naltrexone in Management of Behavioral Outbursts in an Adolescent Male Diagnosed with Disruptive Mood Dysregulation Disorder

Parmar, Ankit; Vats, Deepti; Parmar, Rashmi; Aligeti, Manish

doi:10.1089/cap.2014.0072

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…In an open-label nonrandomized study, Krieger et al (2011) found that risperidone significantly reduced irritability in youth diagnosed with ADHD and SMD. A single case reported successful use of naltrexone in a 15-year-old boy with DMDD, noting increased sedation as the only tolerability issue (Parmar et al 2014). Baweja et al (2016) published an open-label study that reported that stimulant medications (no specific stimulants identified in the study) decreased depressive and ODD symptoms in youth with SMD symptoms, who were retrospectively diagnosed.…”

Section: Introductionmentioning

confidence: 99%

Improvements in Irritability with Open-Label Methylphenidate Treatment in Youth with Comorbid Attention Deficit/Hyperactivity Disorder and Disruptive Mood Dysregulation Disorder

Winters

Fukui

Leibenluft

et al. 2018

Journal of Child and Adolescent Psychopharmacology

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Section: Introductionmentioning

confidence: 99%

Improvements in Irritability with Open-Label Methylphenidate Treatment in Youth with Comorbid Attention Deficit/Hyperactivity Disorder and Disruptive Mood Dysregulation Disorder

Winters

Fukui

Leibenluft

et al. 2018

Journal of Child and Adolescent Psychopharmacology

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Evidence-based treatments for youths with severely dysregulated mood: a qualitative systematic review of trials for SMD and DMDD

Benarous

Consoli

Guilé

et al. 2016

Eur Child Adolesc Psychiatry

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The aim of this literature review was to examine the evidence for psychotherapeutic and pharmacological treatments in subjects with severely dysregulated mood and to identify potential areas for improvements in research designs. A literature search was conducted using several databases for published (PubMed, PsycINFO) and ongoing (clinical trial registries) studies conducted in youths who met NIMH's criteria for Severe Mood Dysregulation (SMD) or the DSM-5 diagnosis of Disruptive Mood Dysregulation Disorder (DMDD). Eight completed studies were identified: three randomized trials, four open pilot studies and one case report. Seven ongoing studies were found in trial registries. The available evidence suggests potential efficacy of psychotherapies which have previously been developed for internalizing and externalizing disorders. The two main pharmacological strategies tested are, first, a monotherapy of psychostimulant or atypical antipsychotic such as risperidone, already used in the treatment of severe irritability in youths with developmental disorders; and second, the use of a serotonergic antidepressant as an add-on therapy in youths treated with psychostimulant. Ongoing studies will further clarify the effectiveness of psychotherapeutic interventions for DMDD individuals and whether they should be given alone or in conjunction with other treatments. The short duration of the trials for a chronic disorder, the low number of studies, the lack of placebo or active comparator arm, and restrictive inclusion criteria in most of the controlled trials dramatically limit the interpretation of the results. Finally, future research should be conducted across multiple sites, with standardized procedures to measure DMDD symptoms reduction, and include a run-in period to limit placebo effect.

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Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature

Mürner-Lavanchy

Kaess

Koenig

2021

Eur Child Adolesc Psychiatry

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Disruptive mood dysregulation disorder (DMDD) involves non-episodic irritability and frequent severe temper outbursts in children. Since the inclusion of the diagnosis in the DSM-5, there is no established gold-standard in the assessment of DMDD. In this systematic review of the literature, we provide a synopsis of existing diagnostic instruments for DMDD. Bibliographic databases were searched for any studies assessing DMDD. The systematic search of the literature yielded K = 1167 hits, of which n = 110 studies were included. The most frequently used measure was the Kiddie Schedule for Affective Disorders and Schizophrenia DMDD module (25%). Other studies derived diagnostic criteria from interviews not specifically designed to measure DMDD (47%), chart review (7%), clinical diagnosis without any specific instrument (6%) or did not provide information about the assessment (9%). Three structured interviews designed to diagnose DMDD were used in six studies (6%). Interrater reliability was reported in 36% of studies (ranging from κ = 0.6–1) while other psychometric properties were rarely reported. This systematic review points to a variety of existing diagnostic measures for DMDD with good reliability. Consistent reporting of psychometric properties of recently developed DMDD interviews, as well as their further refinement, may help to ascertain the validity of the diagnosis.

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Role of Naltrexone in Management of Behavioral Outbursts in an Adolescent Male Diagnosed with Disruptive Mood Dysregulation Disorder

Cited by 7 publications

References 6 publications

Improvements in Irritability with Open-Label Methylphenidate Treatment in Youth with Comorbid Attention Deficit/Hyperactivity Disorder and Disruptive Mood Dysregulation Disorder

Improvements in Irritability with Open-Label Methylphenidate Treatment in Youth with Comorbid Attention Deficit/Hyperactivity Disorder and Disruptive Mood Dysregulation Disorder

Evidence-based treatments for youths with severely dysregulated mood: a qualitative systematic review of trials for SMD and DMDD

Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature

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