Role of nanoparticles in bioimaging, diagnosis and treatment of cancer disorder

Muthuraman, Arunachalam; Rishitha, Narahari; Mehdi, Seema

doi:10.1016/b978-0-12-813669-0.00013-0

Cited by 13 publications

(6 citation statements)

References 183 publications

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“…Then, their physicochemical properties and the behavior of metallic particle liberation, which can change in body distribution, have to be better comprehended for a safe clinical trial with minimal toxic effects (Muthuraman et al, 2018). As mentioned before, in the case of inorganic nanoparticles, besides increasing the specificity, the nanoencapsulation strategy is crucial to decreasing the intrinsic toxicity of metals in different tissues (Mohammadpour et al, 2019;Khan M. A et al, 2021).…”

Section: Limitations Of Using Nanoparticles In Gbm Diagnosismentioning

confidence: 99%

Advances in nano-based materials for glioblastoma multiforme diagnosis: A mini-review

Gusmão

Matsuo

Barbosa

et al. 2022

Front. Nanotechnol.

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The development of nano-based materials for diagnosis enables a more precise prognosis and results. Inorganic, organic, or hybrid nanoparticles using nanomaterials, such as quantum dots, extracellular vesicle systems, and others, with different molecular compositions, have been extensively explored as a better strategy to overcome the blood-brain barrier and target brain tissue and tumors. Glioblastoma multiforme (GBM) is the most common and aggressive primary tumor of the central nervous system, with a short, established prognosis. The delay in early detection is considered a key challenge in designing a precise and efficient treatment with the most encouraging prognosis. Therefore, the present mini-review focuses on discussing distinct strategies presented recently in the literature regarding nanostructures’ use, design, and application for GBM diagnosis.

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Section: Limitations Of Using Nanoparticles In Gbm Diagnosismentioning

confidence: 99%

Advances in nano-based materials for glioblastoma multiforme diagnosis: A mini-review

Gusmão

Matsuo

Barbosa

et al. 2022

Front. Nanotechnol.

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“…Non-injectable nanovectors offer a convenient method for delivery of drugs via oral route. In recent years the use of nanomedical technology has revolutionized healthcare strategies and is envisioned to have a great impact in offering better drug delivery and gene therapy, thus gaining an increasing research interest in the current medical sector of the modern world (Riehemann et al, 2009;Muthuraman et al, 2018;Prasad et al, 2018).…”

Section: Nanomedicinementioning

confidence: 99%

Nanotechnology to the Rescue: Treatment Perspective for the Immune Dysregulation Observed in COVID-19

Peter

Sandeep

Rao

et al. 2021

Front. Nanotechnol.

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The study of the use of nanotechnology for drug delivery has been extensive. Nanomedical approaches for therapeutics; drug delivery in particular is superior to conventional methods in that it allows for controlled targeted delivery and release, higher stability, extended circulation time, minimal side-effects, and improved pharmacokinetic clearance (of the drug) form the body, to name a few. The magnitude of COVID-19, the current ongoing pandemic has been severe; it has caused widespread the loss of human life. In individuals with severe COVID-19, immune dysregulation and a rampant state of hyperinflammation is observed. This kind of an immunopathological response is detrimental and results in rapid disease progression, development of secondary infections, sepsis and can be fatal. Several studies have pin-pointed the reason for this immune dysregulation; deviations in the signaling pathways involved in the mediation and control of immune responses. In severe COVID-19 patients, many signaling cascades including JAK/STAT, NF-κB, MAPK/ERK, TGF beta, VEGF, and Notch signaling were found to be either upregulated or inactivated. Targeting these aberrant signaling pathways in conjunction with antiviral therapy will effectuate mitigation of the hyperinflammation, hypercytokinemia, and promote faster recovery. The science of the use of nanocarriers as delivery agents to modulate these signaling pathways is not new; it has already been explored for other inflammatory diseases and in particular, cancer therapy. Numerous studies have evaluated the efficacy and potential of nanomedical approaches to modulate these signaling pathways and have been met with positive results. A treatment regime, that includes nanotherapeutics and antiviral therapies will prove effective and holds great promise for the successful treatment of COVID-19. In this article, we review different nanomedical approaches already studied for targeting aberrant signaling pathways, the host immune response to SARS-CoV-2, immunopathology and the dysregulated signaling pathways observed in severe COVID-19 and the current treatment methods in use for targeting signaling cascades in COVID-19. We then conclude by suggesting that the use of nanomedical drug delivery systems for targeting signaling pathways can be extended to effectively target the aberrant signaling pathways in COVID-19 for best treatment results.

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“…In comparison with microorganisms, the synthesis of nanoparticles using plant extracts is beneficial because it does away with the difficult process of protective cell cultures and can be successfully scaled up for the synthesis of nanoparticles at a large scale. Thus, the development of such methods that are less hazardous, eco-friendly, cost-effective, and clean for the synthesis of nanoparticles continues to be pursued by the scientific community [ 5 ]. As a result, current research in the pertinent scientific fields has focused on the synthesis of metal oxide nanoparticles using entirely different plant extracts.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and characterization of cobalt nanoparticles using combination of different plants and their antimicrobial activity

et al. 2023

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It has become crucial to biosynthesize efficient, secure, and affordable nanoparticles that we use for the treatment of various infections, including surgical site infection and wound infection, due to the rapid development of microbial resistance to numerous antibiotic drugs. The objective of this study is to biosynthesize cobalt nanoparticles using an extract from the combined peels of garlic (Allium sativum) and onion (Allium cepa). Scanning electron microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), and X-Ray Diffraction were used to confirm the Synthesis of Cobalt Nanoparticle (DRX). Well diffusion was used to measure antimicrobial activity. Escherichia coli, Proteus, Staphylococcus aureus, Staphylococcus cohnii, and Klebsiella pneumonia were the bacterial strains employed Both the crude prepared extract and the biosynthesized Cobalt nanoparticles demonstrated efficacy against all strains of bacteria, but the crude prepared extract displayed a low zone of inhibition ranging from 10 to 13 mm, while the biosynthesized Cobalt nanoparticles displayed a high zone of inhibition ranging from 20 to 24 mm.

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Role of nanoparticles in bioimaging, diagnosis and treatment of cancer disorder

Cited by 13 publications

References 183 publications

Advances in nano-based materials for glioblastoma multiforme diagnosis: A mini-review

Advances in nano-based materials for glioblastoma multiforme diagnosis: A mini-review

Nanotechnology to the Rescue: Treatment Perspective for the Immune Dysregulation Observed in COVID-19

Biosynthesis and characterization of cobalt nanoparticles using combination of different plants and their antimicrobial activity

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