Role of nanotechnology in targeted drug delivery and imaging: a concise review

Koo, Otilia M.; Rubinstein, Israel; Önyüksel, Hayat

doi:10.1016/j.nano.2005.06.004

Cited by 631 publications

(400 citation statements)

References 187 publications

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“…[1][2][3][4][5] Broadly speaking, current methods can be divided into two main categories: "chemical methods," in which biomolecules recognized by the membrane are used in a Trojan-horse strategy that promotes a spontaneous uptake into the cell; and "physical methods," in which micropipettes or electrodes are used to transiently breach the membrane (microinjection and electroporation). Despite the general effectiveness of these methods, there are numerous limitations.…”

Section: Doi: 101002/adma201503252mentioning

confidence: 99%

Spatially, Temporally, and Quantitatively Controlled Delivery of Broad Range of Molecules into Selected Cells through Plasmonic Nanotubes

et al. 2015

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Section: Doi: 101002/adma201503252mentioning

confidence: 99%

Spatially, Temporally, and Quantitatively Controlled Delivery of Broad Range of Molecules into Selected Cells through Plasmonic Nanotubes

et al. 2015

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“…The higher the number of generations is the more terminal groups and bigger size the dendrimer has. The pharmacological and biomedical applicability of dendrimers has been extensively studied and reviewed lately, yet it is still a progressive field of research [1][2][3][4][5][6][7]. Dendrimers are ideal nanocarriers for drugs, because not only the drug itself, but also targeting and imaging molecules can be attached to the same macromolecule.…”

Section: Introductionmentioning

confidence: 99%

A mechanistic view of lipid membrane disrupting effect of PAMAM dendrimers

Berényi

Mihály

Wacha

et al. 2014

Colloids and Surfaces B: Biointerfaces

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The effect of 5 th generation polyamidoamine (PAMAM G5) dendrimers on multilamellar dipalmitoylphosphocholine (DPPC) vesicles was investigated. PAMAM was added in two different concentration to the lipids (10 -3 and 10 -2 dendrimer/lipid molar ratios). The thermal behavior of the evolved systems was characterized by DSC; while the structure and the morphology were investigated with small-and wide-angel X-ray scattering (SWAXS), freeze-fracture electron microscopy (FFTEM) and phosphorus-31 nuclear magnetic resonance ( 31 P-NMR) spectroscopy, respectively. IR spectroscopy was used to study the molecular interactions between PAMAM and DPPC. The obtained results show that the dendrimers added in 10 -3 molar ratio to the lipids generate minor perturbations in the multilamellar structure and thermal character of liposomes, while added in 10 -2 molar ratio dendrimers cause major disturbance in the vesicular system. The terminal amino groups of the dendrimers are in strong interaction with the phosphate headgroups and through this binding dendrimers disrupt the regular multilamellar structure of DPPC. Besides highly swollen, fragmented bilayers, small vesicles are formed.

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“…Protein adsorption on surfaces is important in many fields of bio-and nanotechnology, e.g., for biosensors and biochips, drug delivery materials [3][4][5], implant and other medical device coatings enhancement of surface adhesion is advantageous [2,13,25]. A commonly used strategy to improve adhesion is to increase the specific area of the surface [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Enhanced protein adsorption and cellular adhesion using transparent titanate nanotube thin films made by a simple and inexpensive room temperature process: Application to optical biochips

Nádor

Orgován

Fried

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Please cite this article in press as: J. Nador, et al., Enhanced protein adsorption and cellular adhesion using transparent titanate nanotube thin films made by a simple and inexpensive room temperature process: Application to optical biochips, Colloids Surf. a b s t r a c tA new type of titanate nanotube (TNT) coating is investigated for exploitation in biosensor applications. The TNT layers were prepared from stable but additive-free sols without applying any binding compounds. The simple, fast spin-coating process was carried out at room temperature, and resulted in well-formed films around 10 nm thick. The films are highly transparent as expected from their nanostructure and may, therefore, be useful as coatings for surface-sensitive optical biosensors to enhance the specific surface area. In addition, these novel coatings could be applied to medical implant surfaces to control cellular adhesion. Their morphology and structure was characterized by spectroscopic ellipsometry (SE) and atomic force microscopy (AFM), and their chemical state by X-ray photoelectron spectroscopy (XPS). For quantitative surface adhesion studies, the films were prepared on optical waveguides. The coated waveguides were shown to still guide light; thus, their sensing capability remains. Protein adsorption and cell adhesion studies on the titanate nanotube films and on smooth control surfaces revealed that the nanostructured titanate enhanced the adsorption of albumin; furthermore, the coatings considerably enhanced the adhesion of living mammalian cells (human embryonic kidney and preosteoblast).

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Role of nanotechnology in targeted drug delivery and imaging: a concise review

Cited by 631 publications

References 187 publications

Spatially, Temporally, and Quantitatively Controlled Delivery of Broad Range of Molecules into Selected Cells through Plasmonic Nanotubes

Spatially, Temporally, and Quantitatively Controlled Delivery of Broad Range of Molecules into Selected Cells through Plasmonic Nanotubes

A mechanistic view of lipid membrane disrupting effect of PAMAM dendrimers

Enhanced protein adsorption and cellular adhesion using transparent titanate nanotube thin films made by a simple and inexpensive room temperature process: Application to optical biochips

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