1998
DOI: 10.1002/(sici)1521-4141(199805)28:05<1681::aid-immu1681>3.0.co;2-t
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Role of natural killer cells and TCRγ δ T cells in acute autoimmune encephalomyelitis

Abstract: To elucidate the role of NK cells and TCR + ˇ + T cells in acute experimental autoimmune encephalomyelitis (EAE) induced in Lewis rats, the distribution, number and function of these cells were studied using several methods. Immunohistochemical and flow cytometric analysis revealed that a certain number of NK cells (17 % of the total inflammatory cells) infiltrated the central nervous system (CNS) at the peak stage of EAE and were mainly located in the perivascular region. On the other hand, virtually no TCR +… Show more

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Cited by 151 publications
(108 citation statements)
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“…These mice lack NKT cells, thus implicating conventional NK cells in regulation of EAE. Similar results were obtained in a study performed in Lewis rats, in which depletion of NK cells resulted in a more severe form and an increased incidence of EAE (18). Although these studies have provided strong correlative evidence for a role of NK cells in down-regulating T cell responses, the molecular mechanisms involved in such regulation are not yet fully understood.…”
Section: Nk Cells Inhibit T Cell Proliferation Via P21-mediated Cellsupporting
confidence: 78%
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“…These mice lack NKT cells, thus implicating conventional NK cells in regulation of EAE. Similar results were obtained in a study performed in Lewis rats, in which depletion of NK cells resulted in a more severe form and an increased incidence of EAE (18). Although these studies have provided strong correlative evidence for a role of NK cells in down-regulating T cell responses, the molecular mechanisms involved in such regulation are not yet fully understood.…”
Section: Nk Cells Inhibit T Cell Proliferation Via P21-mediated Cellsupporting
confidence: 78%
“…For example, it has been observed that T cell proliferation and IFN-␥ expression in response to murine CMV infection in mice are enhanced upon in vivo depletion of NK cells (10). Similar depletion studies in animal models of several autoimmune diseases, including EAE (18) and CD4 ϩ T cell-mediated colitis (26), have indicated that NK cells may actively suppress autoreactive T cell responses. It has been suggested that NK cells may mediate this regulatory function via secretion of immunomodulatory cytokines and chemokines or via interaction with other immune cells, such as NKT cells, DCs, and macrophages (12).…”
Section: Discussionmentioning
confidence: 93%
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“…20). Reports of disease amelioration upon NK cell depletion (21)(22)(23)(24)(25)(26) were not confirmed in other studies (27)(28)(29)(30)(31)(32). However, the research was based on several disease models that required different methods of induction, and they may have different pathogenetic mechanisms.…”
Section: Discussionmentioning
confidence: 96%
“…17 Furthermore, there is evidence that NK cells may play a regulatory role in central nervous system diseases, 18 as these cells have also been shown to present in inflammatory CNS lesions. 19,20 At this point, we do not know what regulatory or repair function NK cells maintain in the CNS, but it would likely be important, within a site of damage and inflammatory response, such as the area of SCI, where the blood-brain barrier has been compromised. Therefore, we speculate that the decreased numbers of NK cells in the peripheral circulation of our SCI cohort when compared with their matched controls may represent a shift from the peripheral blood compartment into another area, possibly the CNS compartment.…”
Section: Discussionmentioning
confidence: 99%