Role of natural killer T lymphocytes during helminthic infection

Faveeuw, Christelle; Mallevaey, Thierry; Trottein, François

doi:10.1051/parasite/2008153384

Cited by 16 publications

(14 citation statements)

References 28 publications

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“…NKT cells during helminth infections were shown to produce IL-4 as an immunoregulatory cytokine when exposed to the nematode glycolipids. 163,164 Helminthes activate both iNKT and non-iNKT cells in vivo, enabling them to differentially influence the Th1/Th2 balance. 165 NKT cells were known to be the early source of IL-4 in the spleen within 24 hours of infection with L3 Brugia pahangi in mice.…”

Section: Adaptive Immune Cells In Ir and Immunomodulationmentioning

confidence: 99%

Cell Type-Specific Immunomodulation Induced by Helminthes: Effect on Metainflammation, Insulin Resistance and Type-2 Diabetes

Aravindhan

Anand

2017

The American Journal of Tropical Medicine and Hygiene

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Recent epidemiological studies have documented an inverse relationship between the decreasing prevalence of helminth infections and the increasing prevalence of metabolic diseases ("metabolic hygiene hypothesis"). Chronic inflammation leading to insulin resistance (IR) has now been identified as a major etiological factor for a variety of metabolic diseases other than obesity and Type-2 diabetes (metainflammation). One way by which helminth infections such as filariasis can modulate IR is by inducing a chronic, nonspecific, low-grade, immune suppression mediated by modified T-helper 2 (Th2) response (induction of both Th2 and regulatory T cells) which can in turn suppress the proinflammatory responses and promote insulin sensitivity (IS). This article provides evidence on how the cross talk between the innate and adaptive arms of the immune responses can modulate IR/sensitivity. The cross talk between innate (macrophages, dendritic cells, natural killer cells, natural killer T cells, myeloid derived suppressor cells, innate lymphoid cells, basophils, eosinophils, and neutrophils) and adaptive (helper T [CD4] cells, cytotoxic T [CD8] cells and B cells) immune cells forms two opposing circuits, one associated with IR and the other associated with IS under the conditions of metabolic syndrome and helminth-mediated immunomodulation, respectively.

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Section: Adaptive Immune Cells In Ir and Immunomodulationmentioning

confidence: 99%

Cell Type-Specific Immunomodulation Induced by Helminthes: Effect on Metainflammation, Insulin Resistance and Type-2 Diabetes

Aravindhan

Anand

2017

The American Journal of Tropical Medicine and Hygiene

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“…The role of i NKT cells during helminth infection has recently been appreciated [48]. New findings suggest that, although dispensable for host resistance, i NKT cells play a part in the development of the acquired immune response and in the control of pathology during murine schistosomiasis.…”

Section: Inkt Cells and Non-viral Pathogensmentioning

confidence: 99%

NKT cell immune responses to viral infection

Tessmer

Fatima

Paget

et al. 2008

Expert Opinion on Therapeutic Targets

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Background : Natural killer T (NKT) cells are a heterogeneous population of innate T cells that have attracted interest because of their potential to regulate immune responses to a variety of pathogens. The most widely studied NKT cell subset is the invariant ( i )NKT cells that recognize glycolipids in the context of the CD1d molecule. The multifaceted methods of activation i NKT cells possess and their ability to produce regulatory cytokines has made them a primary target for studies. Objective/methods : To give insights into the roles of i NKT cells during infectious diseases, particularly viral infections. We also highlight mechanisms leading to i NKT cell activation in response to pathogens. Conclusions : i NKT cell's versatility allows them to detect and respond to several viruses. Therapeutic approaches to specifically target i NKT cells will require additional research. Notably, the roles of non-invariant NKT cells in response to pathogens warrant further investigation.

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“…There is a potent inhibitory effect of cAMP signaling on the endotoxinͲmediated production of the proͲinflammatory mediators TNFɲ and leukotriene B4, the leukocyte attracting and activating chemokines ILͲ8, MIPͲ1ɲ and Ͳ1ɴ, and the activator of cytotoxic responses in T and NK cells ILͲ12 (p40), in monocytes and macrophages (132Ͳ137). This inhibition is considered to be primarily [22] responsible for the antiͲinflammatory effect of cAMPͲelevating drugs in vivo. TNFɲ acts as a crucial early initiator of immune responses to pathogens, and is inhibited at a transcriptional level by a mechanism which is not completely understood, but has been proposed to involve the cyclic AMP response element (CRE)Ͳbinding inducible cAMP early repressor (138).…”

Section: Modulation Of Mediator Generationmentioning

confidence: 99%

Lipopolysaccharide attenuates mRNA levels of several adenylyl cyclase isoforms in vivo

Risøe

Wang

Stuestøl

et al. 2007

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Signals that elevate intracellular levels of cyclic adenosine monophosphate (cAMP) are among the factors that control lipopolysaccharide (LPS)-mediated inflammatory mediator production by macrophages. cAMP signaling is also involved in maintaining body functions that are commonly impaired in sepsis, including the endothelial cell barrier function and heart function. Several agents successfully used for sepsis intervention target cAMP signaling, and it was recently shown that liver and lung may be protected from inflammation injury by cAMP-elevating phosphodiesterase inhibitors. Here, we show that LPS attenuates adenylyl cyclase (AC) mRNA levels in liver, lung, heart, spleen and kidney in an animal model of endotoxemia, and in macrophages from liver and lung. In particular, AC5, AC6, AC7 and AC9 mRNA were reduced in most tissues examined and in tissue macrophages. In Kupffer cells, prostaglandin E2-mediated cAMP production was inhibited by LPS treatment. The reduction in AC mRNA by LPS would be expected to lead to a lowered potential for cAMP production in most organs, and in particular, changes in AC6 mRNA may affect endothelial cell barrier function and heart function. In contrast, AC4 mRNA was elevated in heart and lung. The present work indicates a possible mechanism for LPS-mediated alteration of cAMP signaling in vivo.

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Role of natural killer T lymphocytes during helminthic infection

Cited by 16 publications

References 28 publications

Cell Type-Specific Immunomodulation Induced by Helminthes: Effect on Metainflammation, Insulin Resistance and Type-2 Diabetes

Cell Type-Specific Immunomodulation Induced by Helminthes: Effect on Metainflammation, Insulin Resistance and Type-2 Diabetes

NKT cell immune responses to viral infection

Lipopolysaccharide attenuates mRNA levels of several adenylyl cyclase isoforms in vivo

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