Role of natural products and intestinal flora on type 2 diabetes mellitus treatment

Aydin, Ozlem Celik; Aydın, Sonay; Barun, Sureyya

doi:10.12998/wjcc.v11.i1.65

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…In recent years, extensive research has indicated that natural products offer hepatoprotective benefits through their various mechanisms of action in oxidant/antioxidant balance, inflammation, apoptosis, and damage responses. It is commonly acknowledged that allicin is linked to numerous health advantages in humans such as the decreased probability of developing diverse cancers, especially in the gastrointestinal tract [18], as well as cardiovascular disease [19] and type 2 diabetes [20]. In this study, the objective was to investigate the hepatoprotective impact and associated mechanisms of natural allicin, which is a leading bioactive compound derived from garlic.…”

Section: Discussionmentioning

confidence: 99%

Potential Hepatoprotective Effects of Allicin on Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Oxidative Stress, Inflammation, and Apoptosis

Gong,

Wang,

Liu

et al. 2024

Toxics

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The global burden of liver disease is enormous, which highlights the need for effective hepatoprotective agents. It was reported that allicin exhibits protective effects against a range of diseases. In this study, we further evaluated allicin’s effect and mechanism in acute hepatic injury. Liver injury in mice was induced by intraperitoneal injection with 1% CCl4 (10 mL/kg/day). When the first dose was given, CCl4 was given immediately after administration of different doses of allicin (40, 20, and 10 mg/kg/day) as well as compound glycyrrhizin (CGI, 80 mg/kg/day), and then different doses of allicin (40, 20, and 10 mg/kg/day) as well as compound glycyrrhizin (CGI, 80 mg/kg/day) were administrated every 12 h. The animals were dissected 24 h after the first administration. The findings demonstrated a significant inhibition of CCl4-induced acute liver injury following allicin treatment. This inhibition was evidenced by notable reductions in serum levels of transaminases, specifically aspartate transaminase, along with mitigated histological damage to the liver. In this protective process, allicin plays the role of reducing the amounts or the expression levels of proinflammatory cytokines, IL-1β, IL-6. Furthermore, allicin recovered the activities of the antioxidant enzyme catalase (CAT) and reduced the production of malondialdehyde (MDA) in a dose-dependent manner, and also reduced liver Caspase 3, Caspase 8, and BAX to inhibit liver cell apoptosis. Further analysis showed that the administration of allicin inhibited the increased protein levels of Nuclear factor-erythroid 2-related factor 2 (Nrf2) and NAD(P)H:quinone oxidoreductase 1 (NQO1), which is related to inflammation and oxidative stress. The in vitro study of the LPS-induced RAW264.7 inflammatory cell model confirmed that allicin can inhibit important inflammation-related factors and alleviate inflammation. This research firstly clarified that allicin has a significant protective effect on CCl4-induced liver injury via inhibiting the inflammatory response and hepatocyte apoptosis, alleviating oxidative stress associated with the progress of liver damage, highlighting the potential of allicin as a hepatoprotective agent.

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Section: Discussionmentioning

confidence: 99%

Potential Hepatoprotective Effects of Allicin on Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Oxidative Stress, Inflammation, and Apoptosis

Gong,

Wang,

Liu

et al. 2024

Toxics

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show abstract

“…The great majority of trials have found relationships between particular types of bacteria and the illness or its symptoms. Frequently described results included the following species: Bifidobacterium, Bacteroides, Faecalibacterium, Akkermansia, and Roseburia with negative correlation to DM2 and Ruminococcus, Fusobacterium, and Blautia with positive (17).…”

Section: Role Of Gut Microbiota In Type 2 Diabetes Pathophysiologymentioning

confidence: 99%

The role of the gut microbiota in the pathogenesis and therapy of type 2 diabetes mellitus

Madej,

Senat,

Grabowska

et al. 2024

J Educ Health Sport

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INTRODUCTION: Diabetes mellitus type II (DM2) is one of the most frequently diagnosed diseases worldwide with a constantly increasing prevalence. It represents an important clinical challenge. The studies are concentrating on improving our knowledge of both pathogenesis and therapeutic opportunities. The influence of intestinal flora on many health conditions is being investigated. It was found that the gut microbiota of the healthy and diabetic individuals are different. This provides a highly important focus for the consideration of whether and how, based on the content of the intestinal flora, the development and treatment of this disease and its complications can be affected. PURPOSE: The aim of the study is to present the current state of knowledge about the The role of the gut microbiota in the pathogenesis and therapy of type 2 diabetes. MATERIALS AND METHOD: The available literature in PubMed was reviewed to write the article, using the keywords ,,gut microbiota diabetes”, ,,diabetes mellitus”, ,,intestinal microbiome diabetes”, ,,dysbiosis diabetes” and ,,gut microbiota diabetes”. CONCLUSION: The intestinal microbiome is a diverse community of microorganisms that inhabit the gut and has been shown to be essential for the health of the body. Modifications in the diversity and frequency of microorganisms residing in the gut, and the accumulation of metabolites they generate, have been correlated with DM2. The study of intestinal microflora could lead to the discovery of new methods of diagnosis and therapies of DM2 and its complications, such as diabetic kidney disease, neuropathy, retinopathy and cardiovascular disease. In conclusion, further studies are needed to understand the role of the gut microbiome in the pathogenesis and therapy of DM2.

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“…Probiotics synthesize various vitamins and improve the intestinal microbial balance in host. Prebiotics are fermented food components that regulate the composition of gut microbiota and benefit human health (Aydin et al, 2023;Ma et al, 2019). The use of probiotics and prebiotics have been widely investigated on various disease condition.…”

Section: Probiotics and Prebioticsmentioning

confidence: 99%

The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease

Zhao

Zhāng

et al. 2023

Front. Physiol.

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Diabetic kidney disease (DKD) is a common complication in patients with diabetes mellitus (DM). Increasing evidence suggested that the gut microbiota participates in the progression of DKD, which is involved in insulin resistance, renin-angiotensin system (RAS) activation, oxidative stress, inflammation and immunity. Gut microbiota-targeted therapies including dietary fiber, supplementation with probiotics or prebiotics, fecal microbiota transplantation and diabetic agents that modulate the gut microbiota, such as metformin, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose transporter-2 (SGLT-2) inhibitors. In this review, we summarize the most important findings about the role of the gut microbiota in the pathogenesis of DKD and the application of gut microbiota-targeted therapies.

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Role of natural products and intestinal flora on type 2 diabetes mellitus treatment

Cited by 8 publications

References 30 publications

Potential Hepatoprotective Effects of Allicin on Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Oxidative Stress, Inflammation, and Apoptosis

Potential Hepatoprotective Effects of Allicin on Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Oxidative Stress, Inflammation, and Apoptosis

The role of the gut microbiota in the pathogenesis and therapy of type 2 diabetes mellitus

The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease

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