Role of Natural Products in Inflammatory Pharmacology: Harnessing Nature's Potential Through Drug Delivery for Therapeutic Intervention

Abstract

Inflammatory disorders encompass a broad spectrum of conditions marked by abnormal immune responses and persistent inflammation, affecting healthcare and patient wellbeing. Seeking alternative, safe, and efficacious treatments, researchers are turning to natural products within the realm of inflammatory pharmacology. These products, sourced from plants, animals, and microorganisms, hold promise as therapeutic interventions. Natural products exhibit complex interactions with molecular targets and signaling pathways involved in the inflammatory cascade across various diseases. These interactions result in anti-inflammatory (AI) effects and provide potential therapeutic benefits. These advantages may be harnessed via diverse drug delivery methods used for administering these natural products. Plant-derived compounds like CUR (CUR), found in turmeric, exhibit robust AI effects by modulating inflammation-associated pathways. Resveratrol (RES), present in grapes and berries, mitigates inflammation and oxidative stress. Similarly, animal-derived products such as omega-3 fatty acids (OFG) and bee venom components, along with microbial-derived substances like probiotics and fungal metabolites, display notable AI properties. It presents an all-encompassing perspective on the role of natural products in inflammatory pharmacology, scrutinizing their molecular mechanisms, efficacy, and applicability through drug delivery approaches in diverse inflammatory disorders. By synthesizing the latest scientific strides, the article deepens our comprehension of the therapeutic potential of natural products in managing inflammatory conditions through various drug delivery approaches, thereby offering valuable insights for future research and clinical utilization.